strychnine and Bradycardia

In an unanesthetized decerebrate in situ arterially perfused brain stem preparation of mature rat, strychnine (0.05-0.2 microM) blockade of glycine receptors caused postinspiratory glottal constriction to occur earlier, shifting from early expiration to inspiration. This resulted in a paradoxical inspiratory-related narrowing of the upper airway. Stimulation of the trigeminal ethmoidal nerve (EN5; 20 Hz, 100 micros, 0.5-2 V) evoked a diving response, which included a reflex apnea, glottal constriction, and bradycardia. After strychnine administration, this pattern was converted to a maintained phrenic nerve discharge and a reduced glottal constriction that was interrupted intermittently by transient abductions. The onset of firing of postinspiratory neurons shifted from early expiration into neural inspiration in the presence of strychnine, but neurons maintained their tonic activation during EN5 stimulation, as observed during control. Inspiratory neurons that were hyperpolarized by EN5 stimulation in control conditions were powerfully excited after loss of glycinergic inhibition. Thus the integrity of glycinergic inhibition within the pontomedullary respiratory network is critical for the coordination of cranial and spinal motor outflows during eupnea but also for protective reflex regulation of the upper airway.

Topics: Action Potentials; Animals; Apnea; Bradycardia; Diving; Electric Stimulation; Electrophysiology; Female; Glottis; Glycine; Glycine Agents; Male; Neural Inhibition; Phrenic Nerve; Rats; Rats, Wistar; Reflex; Respiratory Mechanics; Strychnine; Trigeminal Nerve

Topics: Adolescent; Adult; Animals; Apnea; Bradycardia; Child; Disease Models, Animal; Electrocardiography; Female; Humans; Infant; Infant, Newborn; Magnesium; Magnesium Deficiency; Male; Pregnancy; Rats; Respiratory System; Strychnine; Sudden Infant Death