strychnine and Atrophy

strychnine has been researched along with Atrophy* in 2 studies

Other Studies

2 other study(ies) available for strychnine and Atrophy

ArticleYear
Chronic GABAergic blockade in the spinal cord in vivo induces motor alterations and neurodegeneration.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Inhibitory GABAergic and glycinergic neurotransmission in the spinal cord play a central role in the regulation of neuronal excitability, by maintaining a balance with the glutamate-mediated excitatory transmission. Glutamatergic agonists infusion in the spinal cord induce motor neuron death by excitotoxicity, leading to motor deficits and paralysis, but little is known on the effect of the blockade of inhibitory transmission. In this work we studied the effects of GABAergic and glycinergic blockade, by means of microdialysis perfusion (acute administration) and osmotic minipumps infusion (chronic administration) of GABA and glycine receptors antagonists directly in the lumbar spinal cord. We show that acute glycinergic blockade with strychnine or GABAergic blockade with bicuculline had no significant effects on motor activity and on motor neuron survival. However, chronic bicuculline infusion, but not strychnine, induced ipsilateral gait alterations, phalange flaccidity and significant motor neuron loss, and these effects were prevented by AMPA receptor blockade with CNQX but not by NMDA receptor blockade with MK801. In addition, we demonstrate that the chronic infusion of bicuculline enhanced the excitotoxic effect of AMPA, causing faster bilateral paralysis and increasing motor neuron loss. These findings indicate a relevant role of GABAergic inhibitory circuits in the regulation of motor neuron excitability and suggest that their alterations may be involved in the neurodegeneration processes characteristic of motor neuron diseases such as amyotrophic lateral sclerosis.

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Bicuculline; Dizocilpine Maleate; Drug Interactions; GABA Antagonists; Gait; Male; Motor Activity; Motor Neurons; Muscle Hypotonia; Nerve Degeneration; Rats; Receptors, Glycine; Spinal Cord; Strychnine

2017
Changes in feeding behavior after intracerebral injections in the rat.
    The American journal of physiology, 1963, Volume: 204

    Topics: Acetylcholine; Animals; Appetite; Atrophy; Epinephrine; Feeding Behavior; Gallamine Triethiodide; Glucose; Histamine; Hypothalamus; Lidocaine; Morphine; Neostigmine; Norepinephrine; Pentobarbital; Pentylenetetrazole; Peptides; Rats; Serotonin; Sodium Chloride; Strychnine; Thirst

1963