strontium-radioisotopes and Vitamin-D-Deficiency

The effects of vitamin D-free diet with low Ca content on 24 hours' 99mTc-methylendiphosphonate retention (in the whole body and tibia), long-term the whole body 85Sr retention and 2 hours' 85Sr catchment in epiphysis, metaphysis and diaphysis of femur and tibia in rats (at the same time in certain experiments femur density and weight after incineration were established) were followed. The whole body 99mTc-MDP retention increases significantly as early as the third day of the diet administration, retention in tibia and the whole body is in further 2 experiments increased after 1, 2 and 4 weeks of the diet (density decreases from the first or the second week). The whole body 85Sr retention is significantly increased as early as after 2 days of the diet, the great difference against controls only slowly decreases after discontinuation of low-Ca diet. Further experiment followed 2 hours' 85Sr catchment in femur and tibia samples after 2, 5, 10 and 20 days of diet--catchment increase is significant after 20 days (bone density and ash weight is significantly decreased after 10 and 20 days of diet). Thus retention of both osteotrophic substances in bone is as a result of low Ca diet increased. This reaction is in case with 85Sr expected, in that of 99mTc-MDP it suggests a possible relation of the catchment and mineral component of osseous tissue. Increased retention of both the substances obviously fails to be related to local blood circulation which was in this situation in our previous experiments decreased.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Bone and Bones; Calcium; Female; Male; Radionuclide Imaging; Rats; Strontium Radioisotopes; Technetium Tc 99m Medronate; Vitamin D Deficiency

The effect of calcium concentration and vitamin B3 25 OHD3 and 1.25 diOHD3 upon intestinal strontium transport was studied in vitamin D deficient rats with duodenal perfusion in situ. When the calcium concentration was increased, the strontium passive absorption was decreased. The vitamin D3 and its derivatives increased intestinal strontium transport significantly and this increment was not modified by calcium. In our experiment, calcium is competitive with strontium only in passive absorption.

Topics: Animals; Calcium; Dihydroxycholecalciferols; Hydroxycholecalciferols; Intestinal Absorption; Male; Rats; Strontium; Strontium Radioisotopes; Vitamin D Deficiency

Topics: Albumins; Animals; Autoradiography; Bone and Bones; Cerium Isotopes; Femur; Fluorine; Humans; Indium; Isotopes; Knee; Male; Organophosphonates; Osteogenesis; Radioisotopes; Radionuclide Imaging; Rats; Regional Blood Flow; Rickets; Strontium Radioisotopes; Technetium; Tibia; Tin; Vitamin D; Vitamin D Deficiency