strontium-radioisotopes and Spinal-Diseases

Previous studies have shown that treatment with daily injections of human parathyroid peptide (hPTH) 1-34 increase axial cancellous bone mass partially at the expense of peripheral cortical bone. In the present work the same hPTH 1-34 regime given for 12 months has been combined with oestrogen or nandrolone therapy to control peripheral bone resorption. Spinal and iliac cancellous (but not cortical) bone increased by 40%-50% above initial values while no perceptible changes occurred in radial cortical or cancellous bone. The evidence of radiokinetic and histomorphometric studies performed before and in the last months of treatment suggested that bone remodeling had proceeded through a transient anabolic phase with increased activation, but that activation had become normal after 11-12 months in the cancellous bone of the ilium whereas it continued to be raised elsewhere in the skeleton. It is concluded that in combination with oestrogens, hPTH peptides given daily injections hold great promise for the treatment of patients with osteoporosis who have already lost substantial amounts of spinal cancellous bone.

Topics: Absorptiometry, Photon; Bone and Bones; Bone Density; Calcium; Humans; Kinetics; Osteogenesis; Osteoporosis; Parathyroid Hormone; Peptide Fragments; Spinal Diseases; Strontium Radioisotopes; Teriparatide; Tomography, X-Ray Computed

The goal of this study was to investigate the acute and chronic effects of paralysis induced by spinal cord section or sciatic neurotomy on bone blood flow in the rat. Regional bone blood flow was measured in the early stage with the hydrogen washout technique and the change of whole bone blood flow was measured in the early and the late stages with the radioactive microsphere technique. Four to 6 h after cordotomy at the level of the 13th thoracic vertebra, the regional bone blood flow in the denervated tibia increased significantly (p less than 0.01). After hemicordotomy with rhizotomy at the same level, the regional bone blood flow in the denervated tibia increased significantly (p less than 0.05) 6 h postoperatively. The whole bone blood flow in the denervated tibia had also increased significantly (p less than 0.05) at 6 h and at 4 and 12 weeks postoperatively. After sciatic neurotomy, the regional and the whole bone blood flow in the paralytic tibia did not change significantly. The present study demonstrated that monoplegic paralysis caused an increase in bone blood flow in the denervated hind limb from a very early stage. It was suggested that the spinal nervous system contributed to the control of bone blood flow.

Topics: Animals; Bone and Bones; Female; Hydrogen; Microspheres; Paralysis; Rats; Rats, Inbred Strains; Regional Blood Flow; Spinal Cord; Spinal Diseases; Strontium Radioisotopes

Topics: Child; Diagnosis, Differential; Female; Humans; Laminectomy; Lumbar Vertebrae; Myelography; Neuroblastoma; Radionuclide Imaging; Spinal Diseases; Spinal Neoplasms; Strontium Radioisotopes