strontium-radioisotopes and Soft-Tissue-Neoplasms

We report a study of strontium kinetics in two patients who received 89Sr therapy for disseminated osteogenic sarcoma, together with estimates of absorbed dose to the principal metastases and to bone marrow. In neither patient did tumour uptake of strontium have a significant effect on whole-body retention. In one patient, whole-body strontium kinetics agreed closely with the ICRP standard model, while in the second, retention was extremely prolonged, probably due to hypertrophic osteoarthropathy. Strontium-85 scintigraphy, surface counting and high-resolution whole-body profiles agreed in showing that in both patients tumour turnover of strontium was very rapid, with a biological half-life of only a few days. Absorbed dose to tumour was found to be comparable in magnitude to the mean bone-marrow dose. We have no reason to believe that 89Sr therapy was of clinical benefit to either patient.

Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Humans; Kinetics; Neoplasm Metastasis; Osteosarcoma; Radiation Dosage; Soft Tissue Neoplasms; Strontium Radioisotopes

Topics: Animals; Body Burden; Bone Marrow Diseases; Bone Neoplasms; Dogs; Dose-Response Relationship, Radiation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Radiation Injuries, Experimental; Radium; Soft Tissue Neoplasms; Strontium Radioisotopes; Time Factors; Toxicology

90Sr was given at three different dose levels (29.6, 14.8 and 7.4 kBq/g b.w.) to groups of mice aged 300, 150, 75 and 25 days. It was found that the incidence of osteosarcomas was highest in the 75-day-old-group and lowest in the two oldest age groups. The frequency of lymphoreticular tumours was inversely dose-related (highest incidence in the lower dose series) and not dependent on age at the time of 90Sr injection. The frequencies of soft tissue tumours indicate that these tumours are more related to age than to the dose employed.

Topics: Age Factors; Animals; Dose-Response Relationship, Radiation; Lymphoma; Mice; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Osteosarcoma; Radiation Dosage; Soft Tissue Neoplasms; Strontium Radioisotopes

Topics: Bone Neoplasms; Gallium Radioisotopes; Humans; Indium; Iodine Radioisotopes; Radioisotopes; Radionuclide Imaging; Selenium; Soft Tissue Neoplasms; Strontium Radioisotopes; Technetium