strontium-radioisotopes and Skin-Neoplasms

Topics: Adrenal Cortex Hormones; Capillaries; Child; Child, Preschool; Cosmetics; Cryosurgery; Hemangioma; Humans; Infant; Neoplasm Regression, Spontaneous; Prognosis; Radiotherapy Dosage; Sclerosing Solutions; Skin Neoplasms; Strontium Radioisotopes; Time Factors; Yttrium Isotopes

Topics: Glomus Tumor; Humans; Nail Diseases; Skin Neoplasms; Strontium Radioisotopes

To determine the efficacy of strontium 90 beta irradiation in the management of cutaneous mast cell tumors (CMCTs) in cats.. Retrospective case series.. 35 client-owned cats with CMCTs.. Medical records of cats with CMCTs in which tumors were radiated by use of a strontium 90 ophthalmic applicator from 1992 to 2002 were reviewed. Cats were included if CMCT was diagnosed, there were no other sites of MCT involvement at the time of treatment, and records contained adequate follow-up information to permit retrospective assessment of local tumor control.. 54 tumors in 35 cats were treated with a median dose of 135 Gy of strontium 90 beta irradiation, resulting in local tumor control in 53 of 54 (98%) tumors with a median follow-up time of 783 days after treatment. Median survival time was 1,075 days. Adverse effects of treatment appeared to be infrequent and of mild severity.. Results indicated that strontium 90 beta irradiation resulted in long-term tumor control and should be considered an effective alternative to surgical resection in management of CMCTs in cats.

Topics: Animals; Cat Diseases; Cats; Dose-Response Relationship, Radiation; Female; Male; Mast-Cell Sarcoma; Retrospective Studies; Skin Neoplasms; Strontium Radioisotopes; Survival Analysis; Time Factors; Treatment Outcome

Clonal origin of skin and bone tumors produced by repeated beta-irradiation was determined by using mice with cellular mosaicism created by random X-chromosome inactivation, on the basis of phosphoglycerate kinase-1 (PGK). The backs of female C3H/He (Pgk-1a/Pgk-1b) mice were exposed to beta rays from 90Sr-90Y at a dose of 3 Gy per exposure 3 times weekly until tumors appeared. The cumulative tumor incidence reached 100% 500 days after the beginning of irradiation, as determined by the Kaplan-Meier method. All 8 tumors examined were of a single PGK phenotype: 5 squamous cell carcinomas and 2 osteosarcomas of A-type, and 1 squamous cell carcinoma of B-type. The absence of double PGK phenotype (AB-type) tumors indicated the monoclonal origin of the tumors produced by repeated irradiation.

Topics: Animals; Beta Particles; Bone Neoplasms; Carcinoma, Squamous Cell; Dosage Compensation, Genetic; Female; Mice; Mice, Inbred C3H; Mosaicism; Neoplasms, Radiation-Induced; Osteosarcoma; Phosphoglycerate Kinase; Skin Neoplasms; Strontium Radioisotopes; Yttrium Radioisotopes

The backs of female ICR mice were irradiated with beta rays from 90Sr-90Y three times a week throughout life. Previously we observed 100% tumor incidence at five different dose levels ranging from 1.5 to 11.8 Gy per exposure, but no tumor on repeated irradiation with 1.35 Gy for 300 days (Radiat. Res. 115, 488, 1988). In the present study, delay of tumor development was again seen at a dose of 1.5 Gy per exposure, with further delay at 1.0 Gy. The final tumor incidence was 100% with these two doses. At 0.75 Gy per exposure, no tumor appeared within 790 days after the start of irradiation, but one osteosarcoma and one squamous cell carcinoma did finally appear. These findings indicate a threshold-like response of tumor induction in this repeated irradiation system and further suggest that the apparent threshold may be somewhat less than 0.75 Gy per exposure.

Topics: Animals; Beta Particles; Bone Neoplasms; Female; Mice; Neoplasms, Radiation-Induced; Radiation Dosage; Skin Neoplasms; Strontium Radioisotopes; Yttrium Radioisotopes

We have shown previously that the risk of tumor initiation, promotion, and progression in animals initiated with alkylating agents can be drastically altered by hyperthermia treatments. We show here that ionizing radiation can also alter the risk of tumor initiation by alkylating agents. Using a two-step skin tumorigenesis protocol in female SENCAR mice (initiation by MNNG, promotion with TPA), we exposed the dorsal skin of the mice to various doses of 90Sr/90Y beta radiation near the time of initiation. The radiation produced a dose-dependent reduction in the number of papillomas which appeared after TPA promotion, with about a 20% reduction in animals receiving 0.5 Gy surface dose just before initiation, about 50% reduction after 2.5 Gy, and greater than 80% at doses above 5 Gy. A dose of 2.5 Gy in animals initiated with DMBA produced no significant reduction. One skin hyperthermia treatment (44 degrees C, 30 min) along with radiation in MNNG-initiated animals partially blocked the protective effect of radiation and increased the papilloma frequency. Radiation (2.5 Gy) given either 6 days before or after MNNG initiation was less effective but still reduced papilloma frequency about 20%. In sharp contrast to the marked reduction in papilloma formation, these same animals showed no change in carcinoma frequency with any of the doses or schedules of beta radiation. MNNG initiation alone produced three types of initiated cells. One type, produced in low yield, was promotion-independent with a high probability of progression to a carcinoma and appeared unaffected by the radiation. A second type, produced in intermediate yield, was promotion-dependent and also had a high progression probability, but was likewise unaffected by the radiation. The third and most abundant type was promotion-dependent with a very low progression probability. Radiation exposure resulted in a decrease in the risk of an MNNG initiation event which led only to the third type of cell. The data therefore indicate that the risk of some, but not all, tumor-initiating events caused by alkylating agents can be reduced by an exposure to ionizing radiation.

Topics: Animals; Beta Particles; Carcinoma; Female; Methylnitronitrosoguanidine; Mice; Papilloma; Skin Neoplasms; Strontium Radioisotopes

When untreated porous calcium phosphate ceramics were transplanted into subcutaneous (s.c.) or intramuscular (i.m.) sites, fibrovascular tissue grew in the pore region without evidence of bone formation. However, when these same ceramics were combined with syngeneic marrow cells, osteogenesis was observed inside the pore region of the implanted ceramic. The osteogenesis began on the surface of the pore region at approximately 3 weeks postimplantation by a process of intramembranous bone formation, with the de novo bone tissue observed directly interfacing with the ceramic surface. Infrequently, small isolated areas showed cartilage formation with no noticeable endochondral ossification. At 4 weeks postimplantation of the ceramic with marrow cells, the osteogenesis in the ceramic accompanied an observed increase in compressive strength, rigidity, and energy absorption of the ceramic. These results suggest that a combination of porous ceramics and marrow cells may be useful for clinical problems requiring osseous reconstruction.

Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Ceramics; Durapatite; Hydroxyapatites; Male; Muscular Diseases; Neoplasms, Experimental; Osteoblasts; Osteogenesis; Permeability; Rats; Rats, Inbred F344; Skin Neoplasms; Strontium Radioisotopes

Topics: Brachytherapy; Child; Child, Preschool; Female; Hemangioma; Humans; Infant; Male; Skin Neoplasms; Strontium Radioisotopes

Topics: Hemangioma; Humans; Skin Neoplasms; Strontium Radioisotopes

The use of strontium 90 has proved to be efficient and practical, because handy, and permitting short treatment, not only, to cure benign superficial tumors and, as reported in this study, of pre-cancerous lesions such as actinic keratosis, Bowen's disease of the skin but also some carefully chosen cases of superficial carcinomas. Hundred lesions have been so treated and followed for 3 years; two only have relapsed. The cosmetic result has been excellent in 80 p. 100.

Topics: Aged; Bowen's Disease; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; Keratosis; Male; Precancerous Conditions; Radiotherapy; Radiotherapy Dosage; Skin Neoplasms; Strontium Radioisotopes

Topics: Angiokeratoma; Female; Hemangioma, Cavernous; Humans; Infant; Male; Skin Neoplasms; Strontium Radioisotopes

Keloids and hemangiomas of the cavernous type which require treatment respond very reliably to X-rays. Adequate use of this therapeutic possibility offers considerable advantages to the patients in many cases and in addition it is without danger. Treatment of hemangiomas with beta radiation in the form of Sr-90/Y-90 plates for shortterm application to the skin is so safe and at the same time so successful that, in view of the not at all rare unfavorable spontaneous course, it seems rather risky to delay the indication to begin radiation therapy at the earliest possible moment.

Topics: Adrenal Cortex Hormones; Burns; DNA, Neoplasm; Hemangioma; Humans; Keloid; Radiotherapy; Skin Neoplasms; Strontium Radioisotopes; Yttrium Radioisotopes

Skin tumors were produced in female ICR mice by 90Sr-90Y beta-irradiation and subsequent 4-nitroquinoline 1-oxide painting. The doses were chosen so as to produce no tumors with a single agent alone; the interval between two treatments ranged from 11 to 408 days. The tumor induction rate was found to be at almost the same level (average, 12.4%) for each interval. The results indicate the persistence of the latent carcinogenic alterations in the beta-irradiated mouse skin.

Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nitroquinolines; Radiation Effects; Skin; Skin Neoplasms; Strontium Radioisotopes; Yttrium Radioisotopes

Topics: Adolescent; Adult; Child, Preschool; Dimethyl Sulfoxide; Female; Humans; Keloid; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Penile Induration; Skin Neoplasms; Strontium Radioisotopes; Vitamin A

Topics: Hemangioma; Humans; Infant; Infant, Newborn; Neoplasms; Skin Neoplasms; Strontium; Strontium Isotopes; Strontium Radioisotopes

Topics: Animals; Carcinoma, Squamous Cell; Fibrosarcoma; Mice; Neoplasms, Experimental; Phosphorus; Phosphorus Radioisotopes; Sarcoma, Experimental; Skin; Skin Neoplasms; Strontium; Strontium Radioisotopes

Topics: Humans; Radioactivity; Skin Neoplasms; Strontium; Strontium Radioisotopes

Topics: Beta Particles; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Sarcoma; Skin Neoplasms; Strontium; Strontium Radioisotopes; Whole-Body Irradiation

Topics: Cobalt; Cobalt Radioisotopes; Gold Radioisotopes; Phosphorus; Phosphorus Radioisotopes; Radioisotopes; Skin Neoplasms; Strontium; Strontium Radioisotopes