strontium-radioisotopes and Sarcoma

An eight-year-old, neutered, male border collie dog was presented with a six-week history of left ocular discomfort and a raised, red mass at the lateral limbus. The right eye had been enucleated approximately 12 months previously following suspected trauma when the eye had become red and painful. The mass was excised using superficial keratectomy/sclerectomy and the surgery site was treated with strontium-90 beta radiation. Histopathological findings were consistent with a diagnosis of haemangiosarcoma. Immunohistochemical staining showed uniform expression of CD31 in neoplastic cells, confirming their endothelial origin. Two further treatments with strontium-90 beta radiation were applied to the surgical site at weekly intervals. Twenty-six weeks after surgery, a second, raised, red limbal mass became apparent at the medial limbus of the left eye. Surgical excision and adjuvant strontium-90 beta plesiotherapy were performed as described for the initial tumour. Routine histopathological analysis confirmed haemangiosarcoma at this site. Eighty-six weeks following the initial presentation, no recurrence of ocular haemangiosarcoma was evident.

Topics: Animals; Combined Modality Therapy; Corneal Surgery, Laser; Dog Diseases; Dogs; Eye Neoplasms; Limbus Corneae; Male; Neoplasm Recurrence, Local; Ophthalmologic Surgical Procedures; Sarcoma; Scleral Diseases; Strontium Radioisotopes; Treatment Outcome

Strontium-90 was inject i.v. into pregnant rats on day 18 post conception (p.c.). This caused a remarkable transplacental radioactivity uptake and accumulation in the ossification centers of the skull basis. The total radiation dose within the surface of these regions was consequently calculated to be 0.6-1.2 Gy within the entire lifespan. About 50% of it was delivered during the 7 days following the injection of the isotope. The pathologic examination of the offspring throughout their lifetime revealed a pituitary tumor frequency in the exposed groups which was about tenfold in the males and threefold in the females in comparison to the controls. A very outstanding result in the animals treated was the occurrence of metastasizing meningeal sarcomas in about 6% of all cases. In four cases (= 2%) the simultaneous occurrence of a pituitary adenoma and of a meningeal sarcoma could be observed.

Topics: Adenoma, Chromophobe; Animals; Female; Maternal-Fetal Exchange; Meningeal Neoplasms; Neoplasms, Radiation-Induced; Pituitary Neoplasms; Pregnancy; Rats; Sarcoma; Strontium Radioisotopes

Topics: Bone Neoplasms; Chondroblastoma; Chondroma; Diphosphates; Evaluation Studies as Topic; Giant Cell Tumors; Humans; Multiple Myeloma; Osteoma, Osteoid; Radionuclide Imaging; Sarcoma; Strontium Radioisotopes; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Aged; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Child, Preschool; Diagnosis, Differential; Humans; Lymphatic Metastasis; Male; Maxillary Neoplasms; Plasmacytoma; Postoperative Care; Preoperative Care; Prognosis; Radioisotope Teletherapy; Radionuclide Imaging; Radiotherapy Dosage; Sarcoma; Strontium Radioisotopes

Topics: Bone Neoplasms; Chondrosarcoma; Fibrosarcoma; Humans; Lymphoma, Large B-Cell, Diffuse; Osteosarcoma; Radiography; Radionuclide Imaging; Sarcoma; Sarcoma, Ewing; Strontium Isotopes; Strontium Radioisotopes; Technetium

Topics: Bone and Bones; Calcium; Calcium, Dietary; Cesium Isotopes; Minerals; Neoplasms, Radiation-Induced; Osteosarcoma; Potassium; Radiation Injuries; Radioactive Fallout; Sarcoma; Soil; Strontium; Strontium Isotopes; Strontium Radioisotopes

Topics: Autoradiography; Bone Neoplasms; Neoplasms; Osteosarcoma; Sarcoma; Strontium; Strontium Radioisotopes

Topics: Animals; Bone Neoplasms; Incidence; Mice; Mice, Inbred CBA; Neoplasms; Osteosarcoma; Sarcoma; Strontium; Strontium Radioisotopes

Topics: Beta Particles; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Sarcoma; Skin Neoplasms; Strontium; Strontium Radioisotopes; Whole-Body Irradiation

Topics: Bone Neoplasms; Neoplasms; Osteosarcoma; Sarcoma; Strontium; Strontium Radioisotopes

Topics: Animals; Bone Neoplasms; Morphogenesis; Neoplasms; Neoplasms, Experimental; Osteosarcoma; Sarcoma; Strontium; Strontium Radioisotopes

Topics: Animals; Arvicolinae; Bone Neoplasms; Fibula; Humans; Neoplasms; Osteosarcoma; Sarcoma; Strontium; Strontium Radioisotopes; Tibia