strontium-radioisotopes and Pulmonary-Embolism

Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our hypothesis for this nonuniform distribution is that particle diameter plays a role in the subsequent distribution of infused oleic acid and the resulting lung injury. We injected 15-mu microspheres 85Sr and then 137-mu microspheres (141Ce) into the right atria of seven dogs, which were killed and the lungs removed. Analysis of the distribution of the two different diameter microspheres within axial slices from the left caudal lobe of each dog revealed a peripheral distribution of the larger diameter microspheres not seen with the smaller microspheres.

Topics: Animals; Cesium Radioisotopes; Dogs; Lung; Microspheres; Oleic Acid; Oleic Acids; Particle Size; Pulmonary Circulation; Pulmonary Embolism; Radionuclide Imaging; Strontium Radioisotopes

Acute lobar pneumonia and pulmonary embolism were induced in rabbits and the blood flow in the pulmonary artery and bronchial arteries was determined using isotopic microspheres. In acute pneumonia the pulmonary artery flow to the involved lung was reduced 8.5 times and the bronchial artery flow was reduced 5.0 times compared to flow in the normal lung. In acute pulmonary embolism, both the pulmonary artery flow (2.3 times) and the bronchial artery flow (2.5 times) were also reduced. For all animals, the reduction in pulmonary artery flow paralleled the reduction in bronchial artery flow (r=0.65).

Topics: Acute Disease; Animals; Blood Flow Velocity; Bronchial Arteries; Cesium Radioisotopes; Female; Microspheres; Pneumonia; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; Rabbits; Strontium Radioisotopes

Topics: Animals; Blood Pressure; Cardiac Output; Cerium; Chromium Radioisotopes; Coronary Circulation; Heart; Heart Ventricles; Oxygen; Partial Pressure; Pulmonary Embolism; Radioisotope Dilution Technique; Radioisotopes; Regional Blood Flow; Scandium; Strontium Radioisotopes; Vascular Resistance