strontium-radioisotopes and Postoperative-Complications

Scleromalacia is a rare but serious complication following excision of an atypical pterygium and postoperative radiation which needs immediate action and treatment. In this case report we describe a successful method for treating this condition with amniotic membrane transplantation. Despite severe blepharoconjunctivitis the patient is now free of recurrence of pterygium for 3 years supporting the use of amnion membranes for covering scleromalacia in inflammatory conditions.

Topics: Aged, 80 and over; Biological Dressings; Conjunctiva; Conjunctival Diseases; Humans; Male; Postoperative Complications; Pterygium; Radiation Injuries; Radiotherapy, Adjuvant; Reoperation; Sclera; Scleral Diseases; Strontium Radioisotopes; Ulcer

Because late vessel failure has been speculated as a possible limitation of vascular brachytherapy, we conducted a prospective clinical evaluation at 6, 12, 24, and 36 months of follow-up after irradiation with strontium-90/yttrium-90 for in-stent restenosis, regardless of the patient's symptomatic status. We report complete 3-year follow-up data for 106 consecutive patients. The cumulative rate of death at 6, 12, 24, and 36 months was 0.9%, 0.9%, 0.9%, and 1.9% respectively. The corresponding rates for acute ST-elevation myocardial infarction were 2.8%, 4.7%, 4.7%, and 4.7%, respectively. The cumulative rate of late thrombotic occlusion at 6, 12, 24, and 36 months was 3.8%, 4.7%, 4.7%, and 4.7%, respectively. The corresponding rates of target lesion revascularization and target vessel revascularization were 8.5% and 12.3% (p = 0.046), 14.2% (p = 0.157) and 18.0% (p = 0.046), 12.3% and 18.9% (p = 0.008), and 21.7% (p = 0.083) and 29.2% (p = 0.005), respectively. The cumulative rate of all major adverse cardiovascular events at 6, 12, 24, and 36 months was 16.1%, 24.5% (p = 0.003), 27.4% (p = 0.083), and 35.8% (p = 0.003), respectively. In conclusion, these results indicate a delayed and, even in the third year after the index procedure, continued restenotic process after beta irradiation of in-stent restenotic lesions.

Topics: Aged; Blood Vessel Prosthesis Implantation; Brachytherapy; Coronary Angiography; Coronary Restenosis; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Postoperative Complications; Prospective Studies; Radiopharmaceuticals; Stents; Strontium Radioisotopes; Treatment Outcome; Yttrium Radioisotopes

We examined the effect of rigid plate application on the radiostrontium clearance of the intact canine femur at 6 months. We examined each of the component surgical steps. We calculated the clearance both for the whole bone and for each of the five transverse sections of the whole bone. Screw application, but not drilling, increased the clearance in the segment about the screw holes. Plate application produced an increase in the segment beneath the plate as well as around the screws and in the whole bone. These changes are accomplished not only by an absolute increase in clearance to the middle three segments, but by a relative diminution in clearance by the most proximal and distal segments. The histomorphometric changes in long bones following rigid plating may be accompanied by regional increases in bone blood flow.

Topics: Animals; Bone and Bones; Bone Diseases, Metabolic; Bone Plates; Bone Screws; Dogs; Femur; Fracture Fixation, Internal; Ischemia; Postoperative Complications; Radionuclide Imaging; Regional Blood Flow; Strontium Radioisotopes

The effects of each of the surgical stages involved in compression plating on the development of cortical thinning and porosity were assessed in the intact midshaft, stress-shielded femoral segments of adult mongrel dogs 6 months postoperatively. The data were evaluated in terms of a postsurgical tetracycline-based measure of remodeling and terminal 85Sr clearance (SrC) values for the plated segments of bone. Drilling had no effect on any parameter. Screw application was associated with minimal cortical thinning (p less than 0.05), while plate fixation clearly promoted thinning (p less than 0.01) and porosity (p less than 0.05). The percentage of labeled osteons, a measure of remodeling activity, increased only after plate fixation (p less than 0.05), and the labeling patterns suggested that most osteons had formed during the first 4 postsurgical months. That none of these changes were correlated with the 6-month SrC values suggests that the development of plate-induced osteopenia involves disparate histomorphometric time constants, rather than lack of any association.

Topics: Animals; Bone and Bones; Bone Diseases, Metabolic; Bone Plates; Bone Screws; Dogs; Femur; Fracture Fixation, Internal; Ischemia; Postoperative Complications; Regional Blood Flow; Strontium Radioisotopes; Wound Healing

Topics: Adult; Aged; Evaluation Studies as Topic; Female; Femoral Neck Fractures; Femur Head Necrosis; Humans; Male; Middle Aged; Postoperative Complications; Radiography; Radionuclide Imaging; Strontium Radioisotopes; Technetium; Time Factors

A rationale for the management of pterygium, based on theory and clinical experience, is presented in this review. Pterygium is classified as primary, secondary (recurrent), or pseudopterygium. Empirical data and proposed theories of pterygium pathogenesis and recurrence are discussed. The treatment of pterygium based on this information is divided into four phases: diagnosis, medical therapy, surgery, and postoperative adjunctive measures. The indications, techniques, results, and complications of the postoperative adjunctive measures used to lower recurrence are considered. Guidelines for the treatment of pterygium are recommended.

Topics: Administration, Topical; Anti-Inflammatory Agents; Glucocorticoids; Humans; Postoperative Complications; Pterygium; Radiotherapy; Recurrence; Strontium Radioisotopes; Thiotepa

During a ten-year period, 211 patients with a diagnosis of pterygium were treated in the University of Texas Medical Branch by a combined effort using a strontium 90 beta ray applicator immediately after surgical excision. Only one patient developed recurrence. No complications were observed during the first year of follow-up.

Topics: Humans; Postoperative Complications; Pterygium; Recurrence; Strontium Radioisotopes

By clinical, radiographic and scintigraphic means we attempted to examine, whether the implantation of a simple head-endoprosthesis after fractures of the femoral neck still has to be considered as an appropriate operating method or whether on principle, primary endoprosthesis should be used. The results prove that in suitable cases and with correct technique the head-endoprosthesis still has justification, especially as the "protrusio acetabuli", known only as complication of pure head-endoprosthesis, is mostly avoidable. Reference to the choice of cases, operating conditions and appropriate methods of examination are given.

Topics: Aged; Evaluation Studies as Topic; Femoral Neck Fractures; Follow-Up Studies; Fracture Fixation; Hip Joint; Humans; Joint Prosthesis; Middle Aged; Movement; Postoperative Complications; Radionuclide Imaging; Strontium Radioisotopes

Sixty-seven hip joints with intracapsular fracture and the 67 opposite, normal hip joints were studied with 85Sr scintimetry from two weeks to six years after fracture. Consistently, fractures that developed osteonecrosis showed extremely high counts at the fracture site and the femoral head; fractures that failed to unite also showed extremely high counts at the fracture site and somewhat lower counts in the femoral head; fractures that were healing normally showed counts at the fracture site that were higher than those of the normal, uninjured hip but lower than those at fracture sites where osteonecrosis or nonunion was present. Prediction of complications by 85Sr scintimetry is not reliable within the first few months on injury; thereafter, however, the procedure has definite diagnostic value, particularly for osteonecrosis.

Topics: Adult; Aged; Bone Diseases; Fractures, Bone; Hip Injuries; Hip Joint; Humans; Middle Aged; Necrosis; Postoperative Complications; Radionuclide Imaging; Strontium Radioisotopes; Time Factors; Wound Healing

Topics: Hip Joint; Humans; Joint Prosthesis; Pain; Postoperative Complications; Radionuclide Imaging; Strontium Radioisotopes

Topics: Adult; Aged; Hip Joint; Humans; Male; Ossification, Heterotopic; Osteotomy; Paraplegia; Periarthritis; Postoperative Complications; Preoperative Care; Radionuclide Imaging; Strontium; Strontium Radioisotopes; Time Factors

Topics: Adolescent; Adult; Aged; Bile Acids and Salts; Blind Loop Syndrome; Colectomy; Duodenum; Female; Humans; Hydroxylation; Ileostomy; Intestinal Diseases; Intestinal Secretions; Male; Middle Aged; Postoperative Complications; Strontium Radioisotopes; Taurocholic Acid; Time Factors; Tritium

Topics: Acetabulum; Aged; Female; Femoral Neck Fractures; Femur Head; Follow-Up Studies; Humans; Joint Prosthesis; Male; Middle Aged; Pelvic Bones; Postoperative Complications; Radionuclide Imaging; Strontium Radioisotopes

Topics: Acetabulum; Femur; Follow-Up Studies; Hip; Hip Joint; Humans; Joint Prosthesis; Postoperative Complications; Radiography; Strontium Radioisotopes; Surgical Wound Infection; Time Factors

Topics: Animals; Blood Coagulation Disorders; Blood Pressure; Blood Volume; Cardiac Output; Cardiac Surgical Procedures; Cattle; Cerium Isotopes; Chromium Radioisotopes; Extracorporeal Circulation; Female; Heart, Artificial; Methylmethacrylates; Microspheres; Monitoring, Physiologic; Polyethylene Terephthalates; Postoperative Complications; Quality Control; Radioisotopes; Silicone Elastomers; Strontium Radioisotopes; Time Factors