strontium-radioisotopes and Neoplasm-Regression--Spontaneous

Topics: Adrenal Cortex Hormones; Capillaries; Child; Child, Preschool; Cosmetics; Cryosurgery; Hemangioma; Humans; Infant; Neoplasm Regression, Spontaneous; Prognosis; Radiotherapy Dosage; Sclerosing Solutions; Skin Neoplasms; Strontium Radioisotopes; Time Factors; Yttrium Isotopes

The spontaneous regression of the erythroleukemia induced by the regressing Friend murine leukemia virus (F-MuLV) complex was inhibited by irradiation of the animals prior to F-MuLV inoculation. This inhibition was proportional to the dose of radiation used. Treatment of the mice with the bone-seeking isotope 89Sr also inhibited erythroleukemia regression, which implicates the same effector mechanisms involved in the resistance to F-MuLV or F-MuLV-induced immunosuprression. Erythroleukemias induced in athymic nude mice by the regressing F-MuLV complex exhibited higher rates of lethality than did the leukemias in heterozygous or homozygous thymus gland-containing controls. These data suggested the involvement of the immune system in erythroleukemia regression and the specific participation of thymus cells and an 89Sr-susceptible function, perhaps marrow-dependent cells, in the process of regression.

Topics: Animals; Friend murine leukemia virus; Immunity; Immunosuppression Therapy; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Male; Mice; Mice, Nude; Neoplasm Regression, Spontaneous; Strontium Radioisotopes; Tumor Virus Infections

Topics: Administration, Oral; Aged; Bone Neoplasms; Diethylstilbestrol; Humans; Hydroxyproline; Injections, Intravenous; Male; Methods; Middle Aged; Neoplasm Metastasis; Neoplasm Regression, Spontaneous; Phosphoric Monoester Hydrolases; Prostatic Neoplasms; Radiography; Strontium Radioisotopes; Time Factors