strontium-radioisotopes and Mast-Cell-Sarcoma

To determine the efficacy of strontium 90 beta irradiation in the management of cutaneous mast cell tumors (CMCTs) in cats.. Retrospective case series.. 35 client-owned cats with CMCTs.. Medical records of cats with CMCTs in which tumors were radiated by use of a strontium 90 ophthalmic applicator from 1992 to 2002 were reviewed. Cats were included if CMCT was diagnosed, there were no other sites of MCT involvement at the time of treatment, and records contained adequate follow-up information to permit retrospective assessment of local tumor control.. 54 tumors in 35 cats were treated with a median dose of 135 Gy of strontium 90 beta irradiation, resulting in local tumor control in 53 of 54 (98%) tumors with a median follow-up time of 783 days after treatment. Median survival time was 1,075 days. Adverse effects of treatment appeared to be infrequent and of mild severity.. Results indicated that strontium 90 beta irradiation resulted in long-term tumor control and should be considered an effective alternative to surgical resection in management of CMCTs in cats.

Topics: Animals; Cat Diseases; Cats; Dose-Response Relationship, Radiation; Female; Male; Mast-Cell Sarcoma; Retrospective Studies; Skin Neoplasms; Strontium Radioisotopes; Survival Analysis; Time Factors; Treatment Outcome

Topics: Animals; Cat Diseases; Cats; Hyperplasia; Inclusion Bodies; Mast Cells; Mast-Cell Sarcoma; Microscopy, Electron; Mitochondria; Radiation Effects; Strontium Radioisotopes