strontium-radioisotopes and Leukemia--Myeloid

Topics: Adenocarcinoma; Aged; Humans; Leukemia, Myeloid; Male; Neoplasms, Radiation-Induced; Prostatic Neoplasms; Strontium Radioisotopes

Topics: Acute Disease; Adolescent; Adult; Age Factors; Bone Neoplasms; Child; Child, Preschool; Cohort Studies; Environmental Exposure; Humans; Incidence; Infant; Leukemia, Myeloid; Leukemia, Radiation-Induced; Lymphoma, Non-Hodgkin; Neoplasms; Nuclear Energy; Risk Factors; Scotland; Strontium Radioisotopes

Cloned cell lines were established from two swine with radiation-induced myeloproliferative disorders, including one cell culture from an animal with myelogenous leukemia and one from an animal with myeloid metaplasia. A third cloned cell line with similar morphology was established from pooled normal fetal swine cornea to compare the growth characteristics of cells from normal and irradiated swine. All three cell lines grew as foci of aggregated cells and were able to form macroscopic colonies in semisolid agar medium. The lack of normal mechanisms of contact inhibition and the observed aneuploidy indicated that these cells were morphologically transformed. Further, the cloned cells caused tumors in nude mice, clearly indicating that these cells were also malignantly transformed. A major difference between these cell lines was that type C viruses were observed only in the cells derived from swine with myeloproliferative disorders.

Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cornea; Karyotyping; Leukemia, Myeloid; Leukemia, Radiation-Induced; Mice; Neoplasms, Experimental; Primary Myelofibrosis; Radiation Injuries, Experimental; Strontium Radioisotopes; Swine

Topics: Cell Division; Karyotyping; Leukemia, Myeloid; Liver; Lymph Nodes; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Splenomegaly; Strontium Radioisotopes

Topics: Adenoviridae; Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Culture Techniques; Cytopathogenic Effect, Viral; DNA Viruses; Inclusion Bodies, Viral; Kidney; Leukemia, Myeloid; Leukemia, Radiation-Induced; Microscopy, Electron; Retroviridae; Strontium Radioisotopes; Swine; Swine Diseases

Topics: Animals; Antibody Formation; Basophils; Bone Marrow; Hematopoietic Stem Cells; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Radiation-Induced; Lymphoma; Primary Myelofibrosis; Radiation Effects; Strontium Radioisotopes; Swine; Swine Diseases

Topics: Animals; Leukemia; Leukemia, Myeloid; Mice; Radiation Injuries, Experimental; Radioactivity; Strontium; Strontium Radioisotopes