strontium-radioisotopes and Femoral-Fractures

In rats, bilateral closed femoral fractures were produced. On the left side, closed intramedullary nailing was done, and on the right side, the nail was inserted by an open procedure. The healing process of the fractures was evaluated at 4, 8, and 12 weeks, bone and muscle blood flows were also determined. Reaming had no acute impact on bone blood flow, while reaming and fracture halved total bone flow (P < 0.04), and reduced cortical diaphyseal flow to approximately one quarter (P < 0.01). No differences were found between the open and closed methods. At 4 weeks, the bending moment, rigidity, and fracture energy of the fractures treated by closed medullary nailing were greater than those treated by open nailing. The fracture energy was still greater at 8 weeks, while no differences were seen in bending moment and rigidity. At 12 weeks, however, there were no differences in the mechanical parameters. Bone blood flows in both the cortical diaphysis and callus area were increased at 4 and in the callus area at 8 weeks in bones treated by the open method. No differences were found at the end of the experiment. Muscle blood flow was not different in the two limbs, and was constant during the experimental period. We conclude that femoral fractures treated by closed nailing heal better in the initial phase compared with those that have been openly nailed. This difference cannot be explained by an impaired muscle or bone blood flow due to open surgery.

Topics: Animals; Blood Flow Velocity; Bony Callus; Cerium Radioisotopes; Evaluation Studies as Topic; Femoral Fractures; Fracture Fixation, Intramedullary; Fracture Healing; Male; Microspheres; Radionuclide Imaging; Rats; Rats, Wistar; Strontium Radioisotopes; Tensile Strength

Topics: Adolescent; Adult; Arthritis, Infectious; Bone Diseases; Bone Neoplasms; Bone Transplantation; Epiphyses, Slipped; Femoral Fractures; Femur Head; Follow-Up Studies; Fractures, Bone; Hip Joint; Humans; Joint Diseases; Osteochondritis; Osteomyelitis; Pseudarthrosis; Radionuclide Imaging; Strontium Radioisotopes; Transplantation, Homologous

Scanning is based on the uptake of a nuclide by the crystal lattice of bone and is related to bone blood flow. Cancer cells do not take up the tracer. Normally, the scan visualizes the highly vascular bones. Scans are useful and are indicated in metastatic bone disease, primary bone tumors, hematologic malignancies and some non-neoplastic diseases. The scan is more sensitive than x-ray in the detection of malignant diseases of the skeleton.

Topics: Adult; Bone Diseases; Bone Neoplasms; Child; Diagnosis, Differential; Evaluation Studies as Topic; Femoral Fractures; Fluorine; Humans; Lymphoma; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteosarcoma; Pelvic Bones; Phosphates; Radiography; Radioisotopes; Radionuclide Imaging; Skull Neoplasms; Strontium Isotopes; Strontium Radioisotopes; Technetium

Topics: Bone Diseases; Female; Femoral Fractures; Femoral Neck Fractures; Fractures, Spontaneous; Humans; Middle Aged; Radionuclide Imaging; Stress, Mechanical; Strontium Radioisotopes

Topics: Evaluation Studies as Topic; Female; Femoral Fractures; Femur Head Necrosis; Fluorine; Hip Joint; Humans; Injections, Intravenous; Joint Diseases; Knee Joint; Middle Aged; Necrosis; Oscillometry; Osteoarthritis; Radionuclide Imaging; Strontium Radioisotopes; Time Factors

Topics: Adolescent; Child; Female; Femoral Fractures; Fractures, Ununited; Humans; Male; Osteotomy; Pseudarthrosis; Radius; Strontium Radioisotopes; Traction; Ulna

Topics: Adolescent; Adult; Aged; Ankle Injuries; Female; Femoral Fractures; Femur Head Necrosis; Follow-Up Studies; Forearm Injuries; Fractures, Bone; Humans; Knee Injuries; Leg Injuries; Male; Middle Aged; Osteitis; Pseudarthrosis; Radionuclide Imaging; Strontium Radioisotopes; Technetium; Thrombophlebitis; Wound Healing