strontium-radioisotopes and Corneal-Ulcer

A 87-year-old female patient with a squamous cell carcinoma of the conjunctiva was treated with local strontium-90 irradiation (with a so-called 'Dermaplatte'). In spite of a relatively low dosage, radiotherapy was followed by a corneal ulcer with consecutive rupture of the cornea. The cause of this unexpected perforation was, besides the effect of low-dose irradiation, probably a metabolic disorder of the cornea and a disturbance of the tear film due to the carcinoma which had spread on Bowman's layer of the cornea in an exophytic manner and was accompanied by a dense lymphocytic infiltration. An exenteration was performed and, at the last examination (1 year later), no local recurrence could be detected.

Topics: Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Conjunctival Neoplasms; Cornea; Corneal Ulcer; Female; Humans; Rupture, Spontaneous; Strontium Radioisotopes

Topics: Animals; Beta Particles; Cornea; Corneal Ulcer; Lagomorpha; Rabbits; Staphylococcal Infections; Strontium Isotopes; Strontium Radioisotopes; Yttrium Isotopes