strictosamide and Influenza--Human

strictosamide has been researched along with Influenza--Human* in 1 studies

Other Studies

1 other study(ies) available for strictosamide and Influenza--Human

Article	Year
Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities. Chemical biology & drug design, 2015, Volume: 86, Issue:4 A series of novel derivatives of strictosamide were synthesized and biologically evaluated. Most of the new compounds exhibited improved activities than the parent compound strictosamide. Among them, compounds Ib and If possessed antiviral activities against influenza A virus (A/Jinan/15/90) with IC50 values of 4.12 and 12.35 μg/mL, respectively. Compound Ie possessed antiviral activity against respiratory syncytial virus (RSV) with an IC50 value of 9.58 μg/mL. Both compounds IIc and IId had moderate antiproliferative effects against five human cancer cell lines. The preliminary structure-activity relationships were also concluded. This study provides a promising new template with potential antiviral activity. Topics: Animals; Antiviral Agents; Cell Proliferation; Dogs; Hep G2 Cells; Humans; Influenza A virus; Influenza, Human; Madin Darby Canine Kidney Cells; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vinca Alkaloids	2015

Article

Year

Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities.

Chemical biology & drug design, 2015, Volume: 86, Issue:4

A series of novel derivatives of strictosamide were synthesized and biologically evaluated. Most of the new compounds exhibited improved activities than the parent compound strictosamide. Among them, compounds Ib and If possessed antiviral activities against influenza A virus (A/Jinan/15/90) with IC50 values of 4.12 and 12.35 μg/mL, respectively. Compound Ie possessed antiviral activity against respiratory syncytial virus (RSV) with an IC50 value of 9.58 μg/mL. Both compounds IIc and IId had moderate antiproliferative effects against five human cancer cell lines. The preliminary structure-activity relationships were also concluded. This study provides a promising new template with potential antiviral activity.

Topics: Animals; Antiviral Agents; Cell Proliferation; Dogs; Hep G2 Cells; Humans; Influenza A virus; Influenza, Human; Madin Darby Canine Kidney Cells; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vinca Alkaloids

2015