streptovaricin-c and Disease-Models--Animal

streptovaricin-c has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for streptovaricin-c and Disease-Models--Animal

Article	Year
Reverse transcriptase inhibitors and chemically induced bladder tumors in mice. Investigative urology, 1977, Volume: 14, Issue:5 Recent immunologic and microbiologic evidence suggests that urothelial tumors may be caused by "C" type oncogenic viruses. Such viruses may exert their oncogenic potential in responce to stimulation by known chemical carcinogens. By means of a unique enzyme, reverse transcriptase, these viruses are able to incorporate genetic information into that of the host, and can thereby be transmitted vertically from generation to generation. An evaluation of the specific antiviral agents dimethylbenzyldemethl-rifampicin and streptovaricin-comples, which inhibit the enzyme reverse transcriptase, revealed no depay in the induction of bladder tumors by the chemical carcinogen, 2-formylamino-4-(5-nitro-2-furyl) thiazole (FANFT) in C3H mice. This observation suggests that the reproduction and release of virus may not be essential in the malignant transformation of bladder epithelial cells, but does not preclude the possiblity that inherited viral genetic information may be involved in the oncogenesis of bladder tumors. Topics: Animals; Disease Models, Animal; FANFT; Genetic Code; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Oncogenic Viruses; Reverse Transcriptase Inhibitors; Rifampin; RNA-Directed DNA Polymerase; Streptovaricin; Urinary Bladder Neoplasms	1977

Article

Year

Reverse transcriptase inhibitors and chemically induced bladder tumors in mice.

Investigative urology, 1977, Volume: 14, Issue:5

Recent immunologic and microbiologic evidence suggests that urothelial tumors may be caused by "C" type oncogenic viruses. Such viruses may exert their oncogenic potential in responce to stimulation by known chemical carcinogens. By means of a unique enzyme, reverse transcriptase, these viruses are able to incorporate genetic information into that of the host, and can thereby be transmitted vertically from generation to generation. An evaluation of the specific antiviral agents dimethylbenzyldemethl-rifampicin and streptovaricin-comples, which inhibit the enzyme reverse transcriptase, revealed no depay in the induction of bladder tumors by the chemical carcinogen, 2-formylamino-4-(5-nitro-2-furyl) thiazole (FANFT) in C3H mice. This observation suggests that the reproduction and release of virus may not be essential in the malignant transformation of bladder epithelial cells, but does not preclude the possiblity that inherited viral genetic information may be involved in the oncogenesis of bladder tumors.

Topics: Animals; Disease Models, Animal; FANFT; Genetic Code; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Oncogenic Viruses; Reverse Transcriptase Inhibitors; Rifampin; RNA-Directed DNA Polymerase; Streptovaricin; Urinary Bladder Neoplasms

1977