streptovaricin-c and Cell-Transformation--Neoplastic

streptovaricin-c has been researched along with Cell-Transformation--Neoplastic* in 6 studies

Other Studies

6 other study(ies) available for streptovaricin-c and Cell-Transformation--Neoplastic

ArticleYear
Selective killing of human T cell lymphotropic virus type I-transformed cell lines by a damavaricin Fc derivative.
    The Journal of antibiotics, 1989, Volume: 42, Issue:5

    n-Pentyl ether of damavaricin Fc (n-pentyl DvFc) preferentially killed human T-cell lymphotropic virus type I (HTLV-I)-transformed cell lines. The mechanism of action of the drug was investigated using MT-4 cells. Cytotoxic action was diminished by the removal of n-pentyl DvFc from the culture or by the addition of sulfhydryl compounds such as 2-mercaptoethanol and dithiothreitol. The killing activity of n-pentyl DvFc was also diminished by membrane-acting agents including quinidine and diphenylhydantoin. Influx and subsequent efflux of Ca2+ were observed when either HTLV-I infected (MT-4 cells) or uninfected cells were treated with n-pentyl DvFc. An efflux of K+ was observed in HTLV-I infected MT-4 cells immediately after the exposure of the cells to n-pentyl DvFc. The K+ efflux, however, was not observed in the uninfected T cells. n-Pentyl DvFc seems to act primarily on the cell surface of MT-4 cells, leading to the perturbation of membrane function. The restoration of cell growth, however, is critically dependent on the presence of dithiothreitol and 2-mercaptoethanol, implying a role for a free sulfhydryl group in the killing activity.

    Topics: Anti-Bacterial Agents; Antiviral Agents; Calcium; Cell Line, Transformed; Cell Membrane; Cell Membrane Permeability; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Dithiothreitol; DNA; Human T-lymphotropic virus 1; Humans; Leukemia, T-Cell; Mercaptoethanol; Phenytoin; Potassium; Quinidine; Streptovaricin; T-Lymphocytes

1989
Inhibition of growth of mouse mammary carcinoma by streptovaricin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 145, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Animals; Cell Transformation, Neoplastic; Female; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Streptovaricin

1974
Potential mechanisms of action of antiviral agents.
    Federation proceedings, 1973, Volume: 32, Issue:6

    Topics: Amantadine; Animals; Antiviral Agents; Azauridine; Cell Transformation, Neoplastic; Cytarabine; Deoxyuridine; DNA-Directed RNA Polymerases; Herpesviridae Infections; Humans; Idoxuridine; Interferons; Protein Biosynthesis; Rifampin; Rifamycins; RNA-Directed DNA Polymerase; RNA, Viral; Streptovaricin; Structure-Activity Relationship; Thiosemicarbazones; Transcription, Genetic; Vaccinia virus

1973
RNA-directed DNA polymerase and virus-induced leukemia in mice.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:5

    Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme. This inhibition of enzyme activity by rifamycin SV derivatives is due to a relatively tight binding between the enzymes and the inhibitors, yet the binding can be reversed by nonionic detergent. The results of this study suggest that RNA-directed DNA polymerase is essential for induction of leukemia by exogenous virus and correlate with the previous observation that the same derivatives block viral transformation in vitro.

    Topics: Animals; Binding Sites; Cell Transformation, Neoplastic; Chromatography, DEAE-Cellulose; Female; Injections, Intravenous; Leukemia, Experimental; Male; Mice; Rauscher Virus; Reverse Transcriptase Inhibitors; Rifamycins; RNA-Directed DNA Polymerase; Splenomegaly; Streptovaricin; Surface-Active Agents

1973
Streptovaricins inhibit focus formation by MSV (MLV) complex.
    Nature: New biology, 1971, Volume: 232, Issue:33

    Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Culture Techniques; DNA Nucleotidyltransferases; Drug Synergism; Interferons; Leukemia Virus, Murine; Mice; Streptovaricin; Time Factors

1971
Selective inhibition by streptovaricin of splenomegaly induced Rauscher leukaemia by virus.
    Nature: New biology, 1971, Volume: 232, Issue:33

    Topics: Animals; Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Erythropoiesis; Leukemia, Experimental; Lymphoma; Mice; Organ Size; Rauscher Virus; Splenomegaly; Streptovaricin; Time Factors

1971