streptonigrin has been researched along with Ataxia Telangiectasia Syndrome in 15 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cells from patients with ataxia telangiectasia (A-T) were shown to be more sensitive to streptonigrin than were cells from normal individuals." | 7.66 | Effects of the DNA strand-cleaving antitumor agent, streptonigrin, on ataxia telangiectasia cells. ( Campbell, JB; Edwards, MJ; Flude, E; Garner, CM; Taylor, AM, 1983) |
| "Streptonigrin is an antitumour antibiotic, which at low doses produces DNA strand breaks in cultured cells leading, e." | 5.27 | Unscheduled DNA synthesis induced by streptonigrin in ataxia telangiectasia fibroblasts. ( Laher, HB; Morgan, GR; Taylor, AM, 1985) |
| "Cells from patients with ataxia telangiectasia (A-T) were shown to be more sensitive to streptonigrin than were cells from normal individuals." | 3.66 | Effects of the DNA strand-cleaving antitumor agent, streptonigrin, on ataxia telangiectasia cells. ( Campbell, JB; Edwards, MJ; Flude, E; Garner, CM; Taylor, AM, 1983) |
| "Nijmegen breakage syndrome is characterized by a variable T cell and B cell immunodeficiency, growth failure, and an increased risk of malignancy." | 1.30 | Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. ( Lederman, H; Lees-Miller, SP; Sullivan, KE; Veksler, E, 1997) |
| " However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption." | 1.29 | TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. ( Collins, FS; Hieter, P; Morrow, DM; Shiloh, Y; Tagle, DA, 1995) |
| "Streptonigrin is an antitumour antibiotic, which at low doses produces DNA strand breaks in cultured cells leading, e." | 1.27 | Unscheduled DNA synthesis induced by streptonigrin in ataxia telangiectasia fibroblasts. ( Laher, HB; Morgan, GR; Taylor, AM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shiloh, Y | 3 |
| Tabor, E | 1 |
| Becker, Y | 1 |
| Taylor, AM | 3 |
| Flude, E | 1 |
| Garner, CM | 1 |
| Campbell, JB | 1 |
| Edwards, MJ | 1 |
| Meyn, MS | 2 |
| Lu-Kuo, JM | 1 |
| Herzing, LB | 1 |
| Morrow, DM | 1 |
| Tagle, DA | 1 |
| Collins, FS | 1 |
| Hieter, P | 1 |
| Ziv, Y | 1 |
| Bar-Shira, A | 1 |
| Jorgensen, TJ | 1 |
| Russell, PS | 1 |
| Sartiel, A | 1 |
| Shows, TB | 1 |
| Eddy, RL | 1 |
| Buchwald, M | 1 |
| Legerski, R | 1 |
| Schimke, RT | 1 |
| Jongmans, W | 2 |
| Verhaegh, GW | 1 |
| Sankaranarayanan, K | 1 |
| Lohman, PH | 2 |
| Zdzienicka, MZ | 2 |
| Strasfeld, L | 1 |
| Allen, C | 1 |
| Wiegant, J | 1 |
| Oshimura, M | 1 |
| James, MR | 1 |
| Sullivan, KE | 1 |
| Veksler, E | 1 |
| Lederman, H | 1 |
| Lees-Miller, SP | 1 |
| Jung, M | 1 |
| Zhang, Y | 1 |
| Dritschilo, A | 1 |
| Pernin, D | 1 |
| Bay, JO | 1 |
| Uhrhammer, N | 1 |
| Bignon, YJ | 1 |
| Loberg, LI | 1 |
| Luther, MJ | 1 |
| Gauger, JR | 1 |
| McCormick, DL | 1 |
| Johnson, MA | 1 |
| Bryant, PE | 1 |
| Jones, NJ | 1 |
| Joenje, H | 1 |
| Nieuwint, AW | 1 |
| Harnden, DG | 1 |
| Laher, HB | 1 |
| Morgan, GR | 1 |
15 other studies available for streptonigrin and Ataxia Telangiectasia Syndrome
| Article | Year |
|---|---|
Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism.
Topics: Ataxia Telangiectasia; Cells, Cultured; Deoxyribose; DNA; Doxorubicin; Ellipticines; Fibroblasts; Fr | 1983 |
Effects of the DNA strand-cleaving antitumor agent, streptonigrin, on ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Cell Survival; Chromosomes, Human; DNA; DNA Replication; Dose-Response Relati | 1983 |
Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.
Topics: Ataxia Telangiectasia; Blotting, Northern; Blotting, Southern; Cell Line, Transformed; Cell Survival | 1993 |
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1.
Topics: Ataxia Telangiectasia; Base Sequence; Bleomycin; Cloning, Molecular; DNA Damage; Fungal Proteins; Ga | 1995 |
Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells.
Topics: Antibiotics, Antineoplastic; Antigens, Viral; Ataxia Telangiectasia; Cell Line, Transformed; Cell Su | 1995 |
Cellular characteristics of Chinese hamster cell mutants resembling ataxia telangiectasia cells.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Ataxia Telangiectasia; Cell Line; Cell Survival; Cr | 1993 |
Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia.
Topics: Apoptosis; Ataxia Telangiectasia; DNA; DNA-Binding Proteins; Fibroblasts; Genes, p53; Humans; Mutati | 1994 |
Human chromosome 11 complements ataxia-telangiectasia cells but does not complement the defect in AT-like Chinese hamster cell mutants.
Topics: Animals; Ataxia Telangiectasia; Cell Survival; Chromosomes, Human, Pair 11; Cricetinae; Cricetulus; | 1993 |
Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome.
Topics: Abnormalities, Multiple; Antigens, Nuclear; Ataxia Telangiectasia; Cell Cycle; Cell Line; Chromosome | 1997 |
Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis.
Topics: Apoptosis; Ataxia Telangiectasia; Blotting, Western; Cell Line; Cell Survival; DNA-Binding Proteins; | 1997 |
ATM heterozygote cells exhibit intermediate levels of apoptosis in response to streptonigrin and etoposide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Ataxia Telangiectasia; Cell Line; Etoposi | 1999 |
60 Hz magnetic fields do not enhance cell killing by genotoxic chemicals in Ataxia telangiectasia and normal lymphoblastoid cells.
Topics: Antibiotics, Antineoplastic; Ataxia Telangiectasia; Cell Division; Cell Line; Cell Survival; Colony- | 2000 |
Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineopla | 2000 |
Oxygen toxicity and chromosomal breakage in ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Bleomycin; Chromosome Aberrations; Chromosomes; DNA Damage; Free Radicals; Hu | 1987 |
Unscheduled DNA synthesis induced by streptonigrin in ataxia telangiectasia fibroblasts.
Topics: Ataxia Telangiectasia; DNA Repair; Dose-Response Relationship, Drug; Fibroblasts; Humans; In Vitro T | 1985 |