Compounds > streptonigrin
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streptonigrin and Abnormalities, Autosome

streptonigrin has been researched along with Abnormalities, Autosome in 33 studies

Research Excerpts

ExcerptRelevanceReference
"We analyzed the induction of chromosomal aberrations in Chinese hamster ovary (CHO) cells exposed to the radiomimetic compound streptonigrin (SN), in order to determine whether interstitial telomeric sequences (ITSs) are involved in the long-term clastogenic effect of this antibiotic."5.38Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. ( Bianchi, MS; Bolzán, AD; Bravo, MV; Mencucci, MV, 2012)
"We analyzed the chromosomal aberrations involving telomeres in the progeny of mammalian cells exposed to the radiomimetic compound streptonigrin (SN) in order to determine if this antineoplastic drug induces long-term telomere instability."1.40The radiomimetic compound streptonigrin induces persistent telomere dysfunction in mammalian cells. ( Bolzán, AD; Castrogiovanni, DC; Paviolo, NS, 2014)
"We analyzed the induction of chromosomal aberrations in Chinese hamster ovary (CHO) cells exposed to the radiomimetic compound streptonigrin (SN), in order to determine whether interstitial telomeric sequences (ITSs) are involved in the long-term clastogenic effect of this antibiotic."1.38Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. ( Bianchi, MS; Bolzán, AD; Bravo, MV; Mencucci, MV, 2012)
"When CHO cells were exposed to SN, chromosomal aberrations (CAs) and sister-chromatid exchanges (SCEs) were formed in a dose-dependent manner (P < 0."1.31Modulation of streptonigrin's clastogenic effects in CHO cells by the metal-chelating agent 1,10-phenanthroline. ( Bianchi, MS; Bolzán, AD; Correa, MV, 2001)
"Nijmegen breakage syndrome is characterized by a variable T cell and B cell immunodeficiency, growth failure, and an increased risk of malignancy."1.30Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. ( Lederman, H; Lees-Miller, SP; Sullivan, KE; Veksler, E, 1997)
" To date, the kinetics of induction and dose-response relationships of reciprocal translocations induced by chemicals have been little investigated."1.30Application of chromosome painting to clastogenicity testing in vitro. ( Marshall, R; Obe, G, 1998)
"The frequency of consistent structural chromosome aberrations was determined for 108 fetuses (day 14 of gestation) from 20 female rabbits treated before conception with 90 micrograms/kg of streptonigrin (NSC-45383)."1.27Evaluation of chemically induced cytogenetic lesions in rabbit oocytes. III. A postimplantation analysis of streptonigrin effects. ( DuFrain, RJ; Huff, VD; Hutton, D; Littlefield, LG; Morrison, WD, 1984)
"The results indicate that Fanconi's anemia lymphocytes fail to exhibit an increased sensitivity to the antimitotic and clastogenic effects of paraquat and streptonigrin."1.27Cytogenetic toxicity of paraquat and streptonigrin in Fanconi's anemia. ( Arwert, F; de Koning, H; Joenje, H; Nieuwint, AW; Oostra, AB; Roozendaal, KJ, 1987)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199017 (51.52)18.7374
1990's9 (27.27)18.2507
2000's4 (12.12)29.6817
2010's3 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paviolo, NS1
Castrogiovanni, DC1
Bolzán, AD9
Sánchez, J1
Bianchi, MS10
Mencucci, MV1
Bravo, MV1
Lacunza, E1
COHEN, MM3
KIHLMAN, BA4
Nasjleti, CE1
Spencer, HH1
Soukup, S1
Takacs, E1
Warkany, J1
Natarajan, AT1
DuFrain, RJ5
Littlefield, LG5
Morrison, WD1
Huff, VD1
Hutton, D1
Wilmer, JL4
Frome, EL1
Hansson, K1
Palitti, F1
Karlsson, MB1
Huff, V1
Testoni, MI3
Bianchi, NO4
López-Camelo, JS1
Sullivan, KE1
Veksler, E1
Lederman, H1
Lees-Miller, SP1
Marshall, R1
Obe, G1
Páez, GL1
Correa, MV1
Wasserman, SS2
Schwartz, S2
Wolff, DJ1
Needleman, BW1
Linscombe, VA1
Gollapudi, BB1
Sinha, AK1
Joenje, H2
Nieuwint, AW2
Taylor, AM1
Harnden, DG1
Oostra, AB1
Arwert, F1
de Koning, H1
Roozendaal, KJ1
Hartley, B1
Bender, MA1
Griggs, HG1
Bedford, JS1
Kaung, DT1
Swartzendruber, AA1

Reviews

1 review available for streptonigrin and Abnormalities, Autosome

ArticleYear
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.
    Mutation research, 1974, Volume: 23, Issue:2

    Topics: Alkylating Agents; Animals; Caffeine; Chromosome Aberrations; Cyanides; Cytarabine; Deoxyadenosines;

1974

Other Studies

32 other studies available for streptonigrin and Abnormalities, Autosome

ArticleYear
The radiomimetic compound streptonigrin induces persistent telomere dysfunction in mammalian cells.
    Mutation research, 2014, Volume: 760

    Topics: Adipose Tissue; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Chromosome Aberrations; Fibro

2014
Relationship between heterochromatic interstitial telomeric sequences and chromosome damage induced by the radiomimetic compound streptonigrin in Chinese hamster ovary cells.
    Mutation research, 2010, Feb-03, Volume: 684, Issue:1-2

    Topics: Animals; Base Sequence; CHO Cells; Chromosome Aberrations; Cricetinae; Cricetulus; Mutagens; Strepto

2010
Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells.
    Mutation research, 2012, Aug-30, Volume: 747, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; CHO Cells; Chromosomal Instability; Chromosome Aberrations; Cr

2012
Effect of recombinant interferon-alpha on streptonigrin-induced chromosome aberrations and sister-chromatid exchanges in hamster cells.
    Mutation research, 2003, Jan-28, Volume: 522, Issue:1-2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; CHO Cells; Chromosome Aberrations; Cric

2003
THE SPECIFIC EFFECTS OF STREPTONIGRIN ACTIVITY ON HUMAN CHROMOSOMES IN CULTURE.
    Cytogenetics, 1963, Volume: 2

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chromosome Aberrations; Chromosomes; Chromosomes, Huma

1963
THE PRODUCTION OF CHROMOSOMAL ABERRATIONS BY STREPTONIGRIN IN VICIA FABA.
    Mutation research, 1964, Volume: 106

    Topics: Anti-Bacterial Agents; Chromosome Aberrations; Pharmacology; Research; Streptonigrin; Toxicology; Vi

1964
Analysis of streptonigrin-induced incomplete chromosome elements and interstitial fragments in Chinese hamster cells using a telomeric PNA probe.
    Environmental and molecular mutagenesis, 2004, Volume: 44, Issue:4

    Topics: Animals; Chromosome Aberrations; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; In Situ H

2004
Chromosome polyploidization in human leukocyte cultures treated with streptonigrin and cyclophosphamide.
    Cancer, 1967, Volume: 20, Issue:1

    Topics: Antibiotics, Antineoplastic; Cell Division; Chromosome Aberrations; Chromosome Disorders; Cyclophosp

1967
Chromosome changes in embryos treated with various teratogens.
    Journal of embryology and experimental morphology, 1967, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure

1967
Potentiation of chromosomal alterations by inhibitors of DNA repair.
    Nucleic acids symposium series, 1984, Issue:13

    Topics: Animals; Anti-Bacterial Agents; Chromatids; Chromosome Aberrations; Deoxyadenosines; DNA Repair; Flo

1984
Evaluation of chemically induced cytogenetic lesions in rabbit oocytes. III. A postimplantation analysis of streptonigrin effects.
    Mutation research, 1984, Volume: 127, Issue:1

    Topics: Animals; Blastocyst; Chromosome Aberrations; Female; Karyotyping; Oocytes; Pregnancy; Rabbits; Sex R

1984
Evaluation of chemically induced cytogenetic lesions in rabbit oocytes. II. A comparison of streptonigrin effects on somatic and germ cells.
    Mutation research, 1982, Volume: 94, Issue:1

    Topics: Animals; Blastocyst; Bone Marrow Cells; Chromosome Aberrations; Dose-Response Relationship, Drug; Fe

1982
Potentiation of x-ray and streptonigrin-induced chromosomal aberrations in human lymphocytes by post-treatments with hydroxyurea and caffeine.
    Hereditas, 1982, Volume: 97, Issue:1

    Topics: Caffeine; Cells, Cultured; Chromosome Aberrations; DNA Repair; Drug Synergism; Humans; Hydroxyurea;

1982
Factors affecting the sensitivity of rabbit lymphoid and bone marrow cells to Streptonigrin-induced chromosome aberrations.
    Cytogenetics and cell genetics, 1981, Volume: 30, Issue:1

    Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; DNA; Interphase; Lymph Nodes; Lymphocytes; Rabbi

1981
Evaluation of chemically induced cytogenetic lesions in rabbit oocytes. I. The test system and the effects of streptonigrin.
    Mutation research, 1981, Volume: 85, Issue:3

    Topics: Animals; Chromosome Aberrations; Chromosomes; Female; Karyotyping; Mutagenicity Tests; Mutagens; Ooc

1981
The effect of washing lymphocytes after in vivo treatment with streptonigrin on the yield of chromosome and chromatid aberrations in blood cultures.
    Mutation research, 1980, Volume: 69, Issue:1

    Topics: Animals; Chromosome Aberrations; Chromosomes; Culture Media; Female; Mutagens; Rabbits; Streptonigri

1980
Clastogenesis induced by streptonigrin in CHO cells.
    In vitro cellular & developmental biology. Animal, 1993, Volume: 29A, Issue:8

    Topics: Animals; CHO Cells; Chromatids; Chromosome Aberrations; Chromosomes; Cricetinae; Mutagenicity Tests;

1993
Enhancement of chromosome aberrations by the combination of DNA substitution with halogenated deoxyuridine and streptonigrin treatments.
    Mutation research, 1996, Jan-16, Volume: 359, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Bromodeoxyuridine; CHO Cells; Chromosome Aberrations; Cricetin

1996
Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome.
    Clinical immunology and immunopathology, 1997, Volume: 82, Issue:1

    Topics: Abnormalities, Multiple; Antigens, Nuclear; Ataxia Telangiectasia; Cell Cycle; Cell Line; Chromosome

1997
Effects of antioxidants on streptonigrin-induced DNA damage and clastogenesis in CHO cells.
    Mutation research, 1997, Feb-03, Volume: 373, Issue:2

    Topics: Animals; Antioxidants; Catalase; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Damage; Liposome

1997
Application of chromosome painting to clastogenicity testing in vitro.
    Environmental and molecular mutagenesis, 1998, Volume: 32, Issue:3

    Topics: Chromosome Aberrations; Chromosome Painting; Evaluation Studies as Topic; Humans; In Situ Hybridizat

1998
Chromosomal response of insect and mammalian cells to streptonigrin: a comparative study.
    Environmental and molecular mutagenesis, 1998, Volume: 32, Issue:4

    Topics: Aedes; Animals; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae; Sister Chromatid Exc

1998
FISH analysis of telomeric repeat sequences and their involvement in chromosomal aberrations induced by radiomimetic compounds in hamster cells.
    Mutation research, 2001, Aug-08, Volume: 479, Issue:1-2

    Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Line; CHO Cells; Chromatids; Chromosome Aberra

2001
Modulation of streptonigrin's clastogenic effects in CHO cells by the metal-chelating agent 1,10-phenanthroline.
    Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Chelating Agents; CHO Cells; Chromosome Aberrations; Cricetina

2001
Factors underlying variation in spontaneous and clastogen-induced sister chromatid exchanges and chromosome breakage frequencies.
    Environmental and molecular mutagenesis, 1990, Volume: 16, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Adult; Alkylating Agents; Bleomycin; Chromosome Aberrations; Female; Human

1990
Spontaneous and clastogen induced chromosomal breakage in scleroderma.
    The Journal of rheumatology, 1991, Volume: 18, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Bleomycin; Cells, Cultured; Chromosome Aberrations; Chromosom

1991
Cytogenetic damage and cytokinetics in streptonigrin-treated human lymphocytes.
    In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1991, Volume: 27A, Issue:8

    Topics: Cell Cycle; Cell Division; Cells, Cultured; Chromatids; Chromosome Aberrations; Humans; Kinetics; Ly

1991
Oxygen toxicity and chromosomal breakage in ataxia telangiectasia.
    Carcinogenesis, 1987, Volume: 8, Issue:2

    Topics: Ataxia Telangiectasia; Bleomycin; Chromosome Aberrations; Chromosomes; DNA Damage; Free Radicals; Hu

1987
Cytogenetic toxicity of paraquat and streptonigrin in Fanconi's anemia.
    Cancer genetics and cytogenetics, 1987, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Anemia, Aplastic; Cells, Cultured; Child; Chromosome Aberrations; Fanconi Anemia;

1987
Hydroxyurea: effect on Cicia chromosomes previously exposed to x-rays or to radiomimetic chemicals.
    Experimental cell research, 1967, Volume: 48, Issue:3

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antitubercular Agents; Caffeine; Chromosome Aber

1967
Effect of chemotherapeutic agents on chromosomes of patients with lung cancer.
    Diseases of the chest, 1969, Volume: 55, Issue:2

    Topics: Adult; Antineoplastic Agents; Carcinoma, Bronchogenic; Chromosome Aberrations; Chromosomes; Cyclopho

1969
The interaction of various drugs with human chromosomes.
    Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie, 1969, Volume: 11, Issue:1

    Topics: Antibiotics, Antineoplastic; Chromatids; Chromosome Aberrations; Humans; In Vitro Techniques; Leukoc

1969