Page last updated: 2024-08-23

stiripentol and Absence Seizure

stiripentol has been researched along with Absence Seizure in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.71)18.2507
2000's3 (8.57)29.6817
2010's22 (62.86)24.3611
2020's8 (22.86)2.80

Authors

AuthorsStudies
Abdel-Rehim, M; Aboul-Enein, MN; Amin, KM; Attia, MI; El-Azzouny, AA; El-Behairy, MF; Maklad, YA1
Heulard, I; Reversat, L; Riban, V; Si Hocine, H; Verleye, M1
Bragazzi, NL; Brigo, F; Igwe, SC4
Aungaroon, G; Franz, DN; Horn, PS; Mehta, A1
Vasquez, A; Wirrell, EC; Youssef, PE1
Chancharme, L; Chemaly, N; Chiron, C; Nabbout, R1
Frampton, JE1
Caraballo, RH; Cross, JH; Guerrini, R; Lagae, L; Nabbout, R; Vigevano, F1
Inoue, Y; Matsui, D; Ohtsuka, Y; Suzuki, K; Yamada, M1
Buxton, L; Dahle, EJ; Handy, L; Johnson, KJ; Mensah, JA; Metcalf, CS; Pernici, CD; Smith, MD; West, PJ; Wilcox, KS1
Fujioka, T; Kato, D; Madokoro, Y; Matsukawa, N; Mizuno, M; Terada, K; Toyoda, T; Uchida, Y1
Aydınlı, N; Bektaş, G; Çalışkan, M; Ozkan, MU; Özmen, M; Tatlı, B; Uzunhan, TA; Yıldız, EP1
Chiron, C2
Eschbach, K; Knupp, KG1
Chancharme, L; Chugani, H; de Menezes, MS; Devinsky, O; Franz, DN; Hamiwka, L; Hernandez, A; Laux, L; Le Guern, ME; Mikati, MA; Morse, RP; Saneto, RP; Sullivan, J; Valencia, I; Wirrell, EC1
Baraban, SC; Dinday, MT; Hortopan, GA1
Auvin, S; Desnous, B; Dournaud, P; Dupuis, N; Gressens, P; Lebon, S; Lecointe, C1
Brigo, F; Storti, M1
Benninger, F; Dressler, A; Feucht, M; Grassl, R; Gröppel, G; Mühlebner, A; Reiter-Fink, E; Reithofer, E; Trimmel-Schwahofer, P1
Scharfman, HE1
Inoue, T; Katsu, T; Lee, S; Otsuki, T; Sada, N1
Brigo, F; Igwe, SC1
Brigo, F; Igwe, SC; Storti, M1
Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Trojnar, MK1
Chemaly, N; Chipaux, M; Chiron, C; Copioli, C; Desguerre, I; Dulac, O; Nabbout, R1
Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D1
Cao, D; Inoue, Y; Ogiwara, I; Ohtani, H; Ohtani, S; Takahashi, Y; Yamakawa, K1
Czuczwar, SJ; Luszczki, JJ1
Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N1
Arends, RH; Baillie, TA; Levy, RH; Shen, DD; Zhang, K1
Boddy, AV; Lepage, F; Levy, RH; Savitch, JL; Shen, DD; Tombret, F1

Reviews

13 review(s) available for stiripentol and Absence Seizure

ArticleYear
Stiripentol add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2022, 09-06, Volume: 9

    Topics: Anticonvulsants; Child; Dioxolanes; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Partial; Humans; Quality of Life; Randomized Controlled Trials as Topic; Seizures

2022
Stiripentol for the treatment of seizures associated with Dravet syndrome in patients 6 months and older and taking clobazam.
    Expert review of neurotherapeutics, 2023, Volume: 23, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Clobazam; Epilepsies, Myoclonic; Humans; Observational Studies as Topic; Randomized Controlled Trials as Topic; Seizures

2023
Stiripentol: A Review in Dravet Syndrome.
    Drugs, 2019, Volume: 79, Issue:16

    Topics: Anticonvulsants; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures

2019
Dravet syndrome: Treatment options and management of prolonged seizures.
    Epilepsia, 2019, Volume: 60 Suppl 3

    Topics: Anticonvulsants; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures; Valproic Acid

2019
Stiripentol add-on therapy for drug-resistant focal epilepsy.
    The Cochrane database of systematic reviews, 2020, 05-26, Volume: 5

    Topics: Anticonvulsants; Child; Dioxolanes; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Partial; Humans; Patient Dropouts; Randomized Controlled Trials as Topic; Seizures

2020
Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2017, 05-18, Volume: 5

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dioxolanes; Epilepsies, Myoclonic; Female; Humans; Male; Patient Dropouts; Randomized Controlled Trials as Topic; Seizures

2017
Stiripentol add-on therapy for focal refractory epilepsy.
    The Cochrane database of systematic reviews, 2018, 05-10, Volume: 5

    Topics: Anticonvulsants; Child; Dioxolanes; Drug Therapy, Combination; Epilepsies, Partial; Humans; Randomized Controlled Trials as Topic; Seizures

2018
Stiripentol for the treatment of seizures associated with Dravet syndrome.
    Expert review of neurotherapeutics, 2019, Volume: 19, Issue:4

    Topics: Anticonvulsants; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures

2019
Stiripentol for the treatment of seizures in Dravet syndrome.
    Expert review of clinical pharmacology, 2019, Volume: 12, Issue:5

    Topics: Animals; Anticonvulsants; Child; Dioxolanes; Drug Approval; Epilepsies, Myoclonic; Humans; Seizures; Status Epilepticus

2019
Antiepileptic drugs for the treatment of severe myoclonic epilepsy in infancy.
    The Cochrane database of systematic reviews, 2013, Nov-19, Issue:11

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dioxolanes; Epilepsies, Myoclonic; Female; Humans; Male; Randomized Controlled Trials as Topic; Seizures

2013
Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2015, Oct-19, Issue:10

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dioxolanes; Epilepsies, Myoclonic; Female; Humans; Male; Randomized Controlled Trials as Topic; Seizures

2015
Stiripentol for focal refractory epilepsy.
    The Cochrane database of systematic reviews, 2015, Oct-21, Issue:10

    Topics: Anticonvulsants; Child; Dioxolanes; Drug Therapy, Combination; Epilepsies, Partial; Humans; Randomized Controlled Trials as Topic; Seizures

2015
Stiripentol.
    Expert opinion on investigational drugs, 2005, Volume: 14, Issue:7

    Topics: Anticonvulsants; Dioxolanes; Drug Interactions; Drugs, Investigational; Humans; Seizures

2005

Trials

1 trial(s) available for stiripentol and Absence Seizure

ArticleYear
Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Female; Humans; Male; Pilot Projects; Prospective Studies; Seizures; Syndrome

2011

Other Studies

21 other study(ies) available for stiripentol and Absence Seizure

ArticleYear
Design and synthesis of novel stiripentol analogues as potential anticonvulsants.
    European journal of medicinal chemistry, 2012, Volume: 47, Issue:1

    Topics: Animals; Anticonvulsants; Dioxolanes; Drug Design; Hand Strength; Male; Mice; Seizures; Stereoisomerism; Toxicity Tests

2012
Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.
    Epilepsia, 2022, Volume: 63, Issue:5

    Topics: Animals; Anticonvulsants; Calcium Channels, T-Type; Dioxolanes; Disease Models, Animal; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Absence; Humans; Pentylenetetrazole; Rats; Rats, Wistar; Seizures

2022
Stiripentol for Drug-Resistant Epilepsy Treatment in Tuberous Sclerosis Complex.
    Pediatric neurology, 2023, Volume: 139

    Topics: Anticonvulsants; Drug Resistant Epilepsy; Humans; Seizures; Treatment Outcome; Tuberous Sclerosis

2023
Initiating stiripentol before 2 years of age in patients with Dravet syndrome is safe and beneficial against status epilepticus.
    Developmental medicine and child neurology, 2023, Volume: 65, Issue:12

    Topics: Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Female; Humans; Infant; Male; Retrospective Studies; Seizures; Status Epilepticus; Treatment Outcome

2023
Long-term safety and effectiveness of stiripentol in patients with Dravet syndrome: Interim report of a post-marketing surveillance study in Japan.
    Epilepsy research, 2021, Volume: 170

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dioxolanes; Epilepsies, Myoclonic; Epileptic Syndromes; Humans; Infant; Japan; Middle Aged; Pharmaceutical Preparations; Product Surveillance, Postmarketing; Seizures; Spasms, Infantile; Young Adult

2021
Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program.
    Epilepsia, 2021, Volume: 62, Issue:7

    Topics: Animals; Anticonvulsants; Body Temperature; Dioxolanes; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Gene Knock-In Techniques; High-Throughput Screening Assays; Hyperthermia; Injections, Intraperitoneal; Male; Mice; National Institute of Neurological Disorders and Stroke (U.S.); NAV1.1 Voltage-Gated Sodium Channel; Seizures; United States

2021
Stiripentol for the treatment of super-refractory status epilepticus with cross-sensitivity.
    Acta neurologica Scandinavica, 2018, Volume: 137, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Dioxolanes; Drug Eruptions; Female; Humans; Male; Middle Aged; Retrospective Studies; Seizures; Status Epilepticus; Young Adult

2018
Efficacy of Stiripentol and the Clinical Outcome in Dravet Syndrome.
    Journal of child neurology, 2019, Volume: 34, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cognitive Dysfunction; Dioxolanes; Drug Resistant Epilepsy; Epilepsies, Myoclonic; Female; Humans; Male; Retrospective Studies; Seizures; Treatment Outcome

2019
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
    Epilepsia, 2013, Volume: 54, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Infant; Male; Retrospective Studies; Seizures; Treatment Outcome; United States; Valproic Acid

2013
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
    Nature communications, 2013, Volume: 4

    Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinical; Epilepsies, Myoclonic; Gene Expression Profiling; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Potassium Compounds; Seizures; Valproic Acid; Voltage-Gated Sodium Channel beta-1 Subunit; Zebrafish; Zebrafish Proteins

2013
Stiripentol exhibits higher anticonvulsant properties in the immature than in the mature rat brain.
    Epilepsia, 2013, Volume: 54, Issue:12

    Topics: Age Factors; Animals; Anticonvulsants; Brain; Brain Chemistry; Dioxolanes; Disease Models, Animal; Male; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; Seizures; Status Epilepticus

2013
Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen.
    Epilepsy research, 2015, Volume: 109

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Bromides; Child; Child, Preschool; Clobazam; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Female; Fructose; Humans; Infant; Levetiracetam; Male; Piracetam; Retrospective Studies; Seizures; Topiramate; Treatment Outcome; Vagus Nerve Stimulation; Valproic Acid; Young Adult

2015
Neuroscience. Metabolic control of epilepsy.
    Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228

    Topics: Animals; Anticonvulsants; Dioxolanes; Enzyme Inhibitors; L-Lactate Dehydrogenase; Safrole; Seizures

2015
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy.
    Science (New York, N.Y.), 2015, Mar-20, Volume: 347, Issue:6228

    Topics: Animals; Anticonvulsants; Dioxolanes; Disease Models, Animal; Enzyme Inhibitors; L-Lactate Dehydrogenase; Membrane Potentials; Mice; Mice, Inbred ICR; Neurons; Patch-Clamp Techniques; Safrole; Seizures; Subthalamic Nucleus

2015
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.
    Epilepsy research, 2010, Volume: 90, Issue:3

    Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepines; Brain Chemistry; Clobazam; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Hand Strength; Male; Mice; Motor Activity; Seizures; Valproic Acid

2010
Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam.
    Brain & development, 2013, Volume: 35, Issue:2

    Topics: Anticonvulsants; Clonazepam; Dioxolanes; Electroencephalography; Epilepsies, Partial; Female; Head Movements; Humans; Infant; Magnetic Resonance Imaging; Seizures; Vomiting

2013
Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome.
    Epilepsia, 2012, Volume: 53, Issue:7

    Topics: Age Factors; Animals; Anticonvulsants; Benzodiazepines; Clobazam; Dioxolanes; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Genetic Predisposition to Disease; Hyperthermia, Induced; Mice; Mice, Transgenic; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Seizures; Sodium Channels

2012
Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis.
    Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 374, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dioxolanes; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Seizures

2006
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
    Epilepsia, 2006, Volume: 47, Issue:11

    Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid

2006
Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect.
    Epilepsy research, 1994, Volume: 18, Issue:2

    Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dioxolanes; Drug Tolerance; Half-Life; In Vitro Techniques; Pentylenetetrazole; Rats; Seizures; Stereoisomerism

1994
Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol.
    Epilepsy research, 1992, Volume: 12, Issue:1

    Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dioxolanes; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism

1992