stilbenes and Vomiting

stilbenes has been researched along with Vomiting* in 4 studies

Trials

3 trial(s) available for stilbenes and Vomiting

ArticleYear
A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma.
    British journal of haematology, 2013, Volume: 160, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Creatinine; Dehydration; Drug Resistance, Neoplasm; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Multiple Myeloma; Pyrazines; Recurrence; Remission Induction; Resveratrol; Salvage Therapy; Stilbenes; Treatment Failure; Vomiting

2013
Phase I trial of combretastatin a-4 phosphate with carboplatin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Feb-15, Volume: 11, Issue:4

    Preclinical evidence of synergy led to a phase I trial employing combretastatin A-4 phosphate (CA4P), a novel tubulin-binding antivascular drug, in combination with carboplatin.. Based on preclinical scheduling studies, patients were treated on day 1 of a 21-day cycle. Carboplatin was given as a 30-minute i.v. infusion and CA4P was given 60 minutes later as a 10-minute infusion.. Sixteen patients with solid tumors received 40 cycles of therapy at CA4P doses of 27 and 36 mg/m(2) together with carboplatin at area under the concentration-time curve (AUC) values of 4 and 5 mg min/mL. The dose-limiting toxicity of thrombocytopenia halted the dose escalation phase of the study. Four patients were treated at an amended dose level of CA4P of 36 mg/m(2) and carboplatin AUC of 4 mg min/mL although grade 3 neutropenia and thrombocytopenia were still observed. Three lines of evidence are adduced to suggest that a pharmacokinetic interaction between the drugs results in greater thrombocytopenia than anticipated: the carboplatin exposure (as AUC) was greater than predicted; the platelet nadirs were lower than predicted; and the deviation of the carboplatin exposure from predicted was proportional to the AUC of CA4, the active metabolite of CA4P. Patient benefit included six patients with stable disease lasting at least four cycles.. This study of CA4P and carboplatin given in combination showed dose-limiting thrombocytopenia. Pharmacokinetic/pharmacodynamic modeling permitted the inference that altered carboplatin pharmacokinetics caused the increment in platelet toxicity.

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nausea; Neoplasms; Neutropenia; Stilbenes; Thrombocytopenia; Treatment Outcome; Vomiting

2005
Combined anti-prolactin and anti-oestrogen therapy for breast carcinoma.
    Clinical oncology, 1977, Volume: 3, Issue:1

    Topics: Aged; Breast Neoplasms; Bromocriptine; Carbidopa; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Levodopa; Middle Aged; Nausea; Prolactin; Remission, Spontaneous; Stilbenes; Tamoxifen; Time Factors; Vomiting

1977

Other Studies

1 other study(ies) available for stilbenes and Vomiting

ArticleYear
[Methonium salt, MG 624, in therapy of post-operative vomiting].
    Minerva anestesiologica, 1958, Volume: 24, Issue:1

    Topics: Parasympatholytics; Postoperative Nausea and Vomiting; Quaternary Ammonium Compounds; Stilbenes; Surgical Procedures, Operative; Vomiting

1958