stilbenes and Testicular-Neoplasms

stilbenes has been researched along with Testicular-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for stilbenes and Testicular-Neoplasms

Article	Year
4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model. Journal of medicinal chemistry, 2010, Sep-23, Volume: 53, Issue:18 New combretastatin A analogues featuring oxazole or N-methylimidazole bridged Z-alkenes and halo- or amino-substituted A-rings were tested against various cancer cell lines and in testicular germ cell tumor xenografts in mice. Imidazoles with 3-halo-4,5-dimethoxy substituted A-rings and 3-amino-4-methoxy substituted B-rings (7b and 8b) were efficacious at nanomolar concentrations against cells of combretastatin A refractory HT-29 colon carcinoma, multidrug-resistant MCF-7/Topo breast carcinoma, and cisplatin-resistant 1411HP testicular germ cell tumor. They induced apoptosis and inhibited tubulin polymerization. While well tolerated by mice at high doses, these imidazoles initiated extensive intratumoral hemorrhage and regressions of highly vascularized 1411HP xenografts. Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Chick Embryo; Cisplatin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Germ Cell and Embryonal; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxazoles; Stilbenes; Structure-Activity Relationship; Testicular Neoplasms; Transplantation, Heterologous; Tubulin Modulators	2010

Article

Year

4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and -N-methylimidazoles that are cytotoxic against combretastatin A resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model.

Journal of medicinal chemistry, 2010, Sep-23, Volume: 53, Issue:18

New combretastatin A analogues featuring oxazole or N-methylimidazole bridged Z-alkenes and halo- or amino-substituted A-rings were tested against various cancer cell lines and in testicular germ cell tumor xenografts in mice. Imidazoles with 3-halo-4,5-dimethoxy substituted A-rings and 3-amino-4-methoxy substituted B-rings (7b and 8b) were efficacious at nanomolar concentrations against cells of combretastatin A refractory HT-29 colon carcinoma, multidrug-resistant MCF-7/Topo breast carcinoma, and cisplatin-resistant 1411HP testicular germ cell tumor. They induced apoptosis and inhibited tubulin polymerization. While well tolerated by mice at high doses, these imidazoles initiated extensive intratumoral hemorrhage and regressions of highly vascularized 1411HP xenografts.

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Chick Embryo; Cisplatin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Germ Cell and Embryonal; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxazoles; Stilbenes; Structure-Activity Relationship; Testicular Neoplasms; Transplantation, Heterologous; Tubulin Modulators

2010