stilbenes and Peripheral-Nerve-Injuries

stilbenes has been researched along with Peripheral-Nerve-Injuries* in 1 studies

Other Studies

1 other study(ies) available for stilbenes and Peripheral-Nerve-Injuries

ArticleYear
The effects of resveratrol on chronic constriction injury of sciatic nerve in rats.
    Neuroscience letters, 2014, Feb-21, Volume: 561

    The aim of this study was to investigate the effects of resveratrol (RVT) in chronic constriction injury (CCI) of sciatic nerve by behavioral, histomorphological and immunohistochemical evaluations in rats. In this study, male Wistar rats were divided into three groups: sham (n=7), CCI+saline (n=7) and CCI+RVT (n=7). After inducing CCI, treatment with 10mg/kg/day of RVT or saline for 14 days was given. Locomotor function was assessed with rota-rod and open field tests. Morphologic alterations of sciatic nerve were assessed histologically by light and electron microscopy. Immunohistochemistry for insulin-like growth factor-1 (IGF-1) were performed. RVT treatment prevented motor impairment and histomorphological alterations caused by chronic constriction injury of sciatic nerve. IGF-1 immunoreactivity was significantly higher in RVT treated group then CCI induced group and positive correlated with morphometric parameters. These results indicate that RVT may reduce CCI induced damage and this effect may be mediated through the restoration of IGF-1 immunoreactivity.

    Topics: Animals; Antioxidants; Chronic Disease; Constriction, Pathologic; Immunohistochemistry; Insulin-Like Growth Factor I; Male; Motor Activity; Neuroprotective Agents; Peripheral Nerve Injuries; Rats, Wistar; Resveratrol; Sciatic Nerve; Stilbenes

2014