stilbenes has been researched along with Nephritis--Interstitial* in 1 studies
1 other study(ies) available for stilbenes and Nephritis--Interstitial
| Article | Year |
|---|---|
Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease.
We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD).. We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy.. Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1β secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD.. Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD. Topics: Animals; Antibodies; Autophagy; Cell Line; Cell Survival; Creatinine; Drug Carriers; Drug Liberation; Epithelial Cells; Hepatitis A Virus Cellular Receptor 1; Humans; Inflammasomes; Interleukin-1beta; Kidney Tubules; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Nephritis, Interstitial; NLR Family, Pyrin Domain-Containing 3 Protein; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Renal Insufficiency, Chronic; Resveratrol; Stilbenes | 2017 |