stilbenes has been researched along with Metaplasia* in 5 studies
5 other study(ies) available for stilbenes and Metaplasia
Article | Year |
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Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation.
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a polyphenol found in the skin of the grape and red wine, has been found to have chemopreventitive effects in some carcinogenic models. The effects of resveratrol on the initiation of Barrett's metaplasia and the carcinogenic progression to esophageal adenocarcinoma have not been evaluated. The aim of this study was to evaluate the effects of resveratrol on the transition from reflux esophagitis to Barrett's metaplasia to dysplasia to esophageal adenocarcinoma in an established rat model. Male Sprague-Dawley rats underwent esophagoduodenal anastomosis as per institutional approved protocol. They were then treated twice weekly with intraperitoneal injection of 7 mg/kg of resveratrol or saline. Additional nonoperated rats served as controls. The rats in each group were assigned to 1, 3, or 5-month subgroups. The distal esophagus was preserved for blinded histopathological examination at the time of harvest. Thirty-one animals in the 5-month resveratrol group showed a decreased severity of esophagitis (P<0.0001), incidence of intestinal metaplasia (P = 0.3567), and incidence of carcinoma (P = 0.4590) as compared with both the saline and nonoperated control groups. In conclusion, morphological characteristics consistent with decreased esophagitis and incidences of metaplasia and esophageal adenocarcinoma were seen on histopathology in the resveratrol group. Resveratrol resulted in a small diminution of the carcinogenic effects and progression to metaplasia, and further human studies are designed to explore the potential anticarcinogenic mechanism. Topics: Animals; Anticarcinogenic Agents; Apoptosis; Catalase; Disease Models, Animal; Disease Progression; Esophageal Neoplasms; Esophagus; Glutathione; Immunohistochemistry; In Situ Nick-End Labeling; Male; Metaplasia; Oxidative Stress; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2009 |
Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol.
Topics: Abnormalities, Drug-Induced; Animals; Cervix Uteri; Diethylstilbestrol; Estradiol; Fallopian Tubes; Female; Genital Neoplasms, Female; Genitalia, Female; Hyperplasia; Metaplasia; Mice; Ovary; Pregnancy; Stilbenes; Uterus; Vagina | 1980 |
[EXPERIMENTAL CYSTOSIS OF THE THYMUS].
Topics: Cysts; Metaplasia; Pathology; Rats; Research; Stilbenes; Thymus Hyperplasia; Thymus Neoplasms; Toxicology | 1964 |
[HEALING PROCESSES IN THE PROSTATE BED AFTER TRANSURETHRAL RESECTION AND PROSTATECTOMY WITH MICROSCOPIC EXAMINATIONS ON THE EFFECTS OF STILBENES].
Topics: Estrogens; Geriatrics; Humans; Male; Metaplasia; Pathology; Pharmacology; Prostate; Prostatectomy; Stilbenes; Urethra; Urinary Bladder; Wound Healing | 1964 |
Studies on squamous metaplasia in rat bladder. II. Effects of estradiol and estradiol plus hexestrol.
Topics: Animals; Estradiol; Hexestrol; Metaplasia; Rats; Stilbenes; Urinary Bladder | 1960 |