stilbenes and Lewy-Body-Disease

Dementia is a collection of symptoms affecting a person's cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer's disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.

Topics: Alzheimer Disease; Dementia; Glucosides; Humans; Lewy Body Disease; Stilbenes

Topics: Aniline Compounds; Brain; Female; Hormones; Humans; Hypopituitarism; Insulin-Like Growth Factor I; Lewy Body Disease; Magnetic Resonance Imaging; Middle Aged; Nortropanes; Positron-Emission Tomography; Stilbenes

Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain Diseases; Cognitive Dysfunction; Deep Learning; Female; Humans; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Parkinsonian Disorders; Positron-Emission Tomography; Retrospective Studies; Stilbenes

In addition to Lewy body pathology, amyloid-β plaques and neurofibrillary tangles that are characteristic for Alzheimer's disease are also frequently found in Lewy body diseases.. The objective of this study was to investigate tau accumulation patterns in dementia with Lewy bodies and other Lewy body diseases using in vivo. The study included 12 Parkinson's disease (PD) patients with normal cognition, 22 PD patients with cognitive impairment, and 18 dementia with Lewy bodies patients. In addition, 25 Alzheimer's disease patients and 25 healthy controls were included for comparison. All participants underwent. When compared with the controls, dementia with Lewy bodies patients showed slightly increased. Dementia with Lewy bodies patients may harbor

Topics: Aged; Amyloid; Aniline Compounds; Carbolines; Cerebral Cortex; Cognition Disorders; Contrast Media; Female; Humans; Image Processing, Computer-Assisted; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Retrospective Studies; Stilbenes; tau Proteins