stilbenes and Hepatitis-C

Chronic viral infections like those caused by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause disease that establishes an ongoing state of chronic inflammation. While there have been tremendous improvements towards curing HCV with directly acting antiviral agents (DAA) and keeping HIV viral loads below detection with antiretroviral therapy (ART), there is still a need to control inflammation in these diseases. Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function. Natural products represent a vast toolkit to dissect and define how cellular metabolism controls cellular immune and inflammatory function.

Topics: Biological Products; Chronic Disease; Curcumin; Hepatitis C; HIV Infections; Humans; Immunity, Cellular; Immunologic Factors; Inflammation; Resveratrol; Silymarin; Stilbenes

Hepatitis C virus infection and interferon treatment have shown to be risk factors for sleep disorder health-related quality of life.. To determine whether the effects of resveratrol on sleep disorders were associated with different tests in subjects with chronic hepatitis C treated with Peg-IFN-α and RBV.. In this prospective, randomized, placebo controlled, double blind clinical trial, 30 subjects (Group A) with chronic hepatitis received Pegylated-Interferon-α2b (1.5 mg/kg per week), Ribavirin and placebo (. The comparison between Group A and Group B showed significant differences after six months in C-reactive protein (. Supplementation with Resveratrol decreased General Health Questionnaire score and reduced sleep disorders in patients treated with Peg-IFN-α and RBV.

Topics: Acetylcysteine; Adult; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Blood Glucose; Body Mass Index; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Lactoferrin; Male; Middle Aged; Polyethylene Glycols; Prospective Studies; Quality of Life; Recombinant Proteins; Resveratrol; Ribavirin; Sleep Wake Disorders; Stilbenes; Surveys and Questionnaires

This issue hosts diverse topics, from myeloid derived suppressor cells (MDSC) with their mechanism and role in cancer, the interplay between diet and emerging allergies studied in a genetically closed population, the pleiotropic anti-inflammatory effects of resveratrol, to the quest to achieve more reliable immune correlates of protection against the hepatitis C virus (HCV).

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Hepatitis C; Humans; Hypersensitivity; Immune System; Models, Immunological; Myeloid Cells; Neoplasms; Resveratrol; Stilbenes; Viral Hepatitis Vaccines