stilbenes and Epilepsy--Temporal-Lobe

stilbenes has been researched along with Epilepsy--Temporal-Lobe* in 2 studies

Other Studies

2 other study(ies) available for stilbenes and Epilepsy--Temporal-Lobe

ArticleYear
Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.
    Neuroscience bulletin, 2017, Volume: 33, Issue:3

    Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Kainic Acid; Resveratrol; Stilbenes; Up-Regulation

2017
Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats.
    Neurochemical research, 2009, Volume: 34, Issue:8

    Resveratrol (Res) is a phytoalexin produced naturally by several plants, which has multi functional effects such as neuroprotection, anti-inflammatory, and anti-cancer. The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat. We performed behavior monitoring, intracranial electroencepholography (IEEG) recording, histological analysis, and Western blotting to evaluate the anti-epilepsy effect of Res in kainate-induced epileptic rats. Res decreased the frequency of spontaneous seizures and inhibited the epileptiform discharges. Moreover, Res could protect neurons against kainate-induced neuronal cell death in CA1 and CA3a regions and depressed mossy fiber sprouting, which are general histological characteristics both in TLE patients and animal models. Western blot revealed that the expression level of kainate receptors (KARs) in hippocampus was reduced in Res-administrated rats compared to that in epileptic ones. These results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.

    Topics: Animals; Anticonvulsants; Behavior, Animal; Blotting, Western; Cell Death; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Wistar; Receptors, Kainic Acid; Resveratrol; Seizures; Stilbenes

2009
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