stilbenes and Dry-Eye-Syndromes

In the present study, a pterostilbene-peptide amphiphile (PS-GA-RGD) that can spontaneously self-assemble into prodrug nanomedicine, was rationally designed and developed as a novel ophthalmic formulation for the potential management of dry eye. The formed PS-GA-RGD nanomedicine was characterized by dynamic latter scattering (DLS) and transmission electron microscopy (TEM). After esterase treatment, active pterostilbene (PS) sustainably released from the PS-GA-RGD nanomedicine within 48 h, as indicated by an in vitro release study. In comparison with native PS, the formed PS-GA-RGD nanomedicine caused minimal cytotoxicity towards RAW 264.7 and HCEC cells in the 0-20 μM range and did not delay wound healing of HCEC monolayer within 6 h. Furthermore, PS-GA-RGD nanomedicine effectively reduced the intracellular reactive oxygen species (ROS) level in H

Topics: Administration, Ophthalmic; Animals; Anti-Inflammatory Agents; Antioxidants; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Dry Eye Syndromes; Epithelium, Corneal; Esterases; Glutarates; Humans; Kinetics; Macrophages; Male; Mice; Nanoparticles; Oligopeptides; Ophthalmic Solutions; Prodrugs; Rabbits; RAW 264.7 Cells; Stilbenes; Wound Healing

Polydatin (also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, or 3,5,4'-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound isolated from the root and rhizome of

Topics: Animals; Disease Models, Animal; Dry Eye Syndromes; Fallopia japonica; Glucosides; Inflammasomes; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Plant Roots; Rats; Signal Transduction; Stilbenes