stilbenes and Communicable-Diseases

The concept of repurposing previously approved medications to the treatment of new indications by taking advantage of off-target effects has gained traction in recent years, particularly in areas of medicine that do not offer large profits to pharmaceutical firms. As infectious disease discovery research has declined among large pharmaceutical companies, the potential payoff of repurposing has become attractive. From these efforts, the triphenylethylene class of selective estrogen receptor modulators related to tamoxifen has shown activity against a wide range of medically important human pathogens, including bacteria, fungi, parasites, and viruses. Because it has activity against many pathogens affecting people in resource-limited areas of the world, TAM and related drugs may be particularly useful. Here, we review the

Topics: Animals; Bacteria; Communicable Diseases; Drug Repositioning; Estrogen Receptor Antagonists; Female; Humans; Mice; Parasites; Stilbenes; Tamoxifen; Toremifene; Viruses