stilbenes and Bacterial-Infections

Phenolics, which are secondary metabolites of plants, exhibit remarkable bioactivities. In this contribution, we have focused on their protective effect against chronic diseases rather than their antioxidant activities, which have been widely discussed in the literature. A large body of epidemiological studies has proven the bioactivities of phenolics in both standard compounds and natural extracts: namely, anticancer, anti-inflammatory, and antibacterial activities as well as reducing diabetes, cardiovascular disease, and neurodegenerative disease. Phenolics also display anti-analgesic, anti-allergic, and anti-Alzheimer's properties. Thus, this review provides crucial information for better understanding the bioactivities of phenolics in foods and fills a gap in the existing collective and overall knowledge in the field.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Bacterial Infections; Chalcones; Coumaric Acids; Edible Grain; Flavonoids; Fruit; Humans; Hydroxybenzoates; Inflammation; Neoplasms; Stilbenes; Vegetables

Bacterial biofilms are the root cause of persistent and chronic phytopathogenic bacterial infections. Therefore, developing novel agrochemicals that target the biofilm of phytopathogenic bacteria has been regarded as an innovative tactic to suppress their invasive infection or decrease bacterial drug resistance. In this study, a series of natural pterostilbene (PTE) derivatives were designed, and their antibacterial potency and antibiofilm ability were assessed. Notably, compound

Topics: Anti-Bacterial Agents; Bacterial Infections; Biofilms; Microbial Sensitivity Tests; Oryza; Plant Diseases; Propanolamines; Stilbenes; Xanthomonas

Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).

Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacteria; Bacterial Infections; Flavonoids; Humans; Mycobacterium tuberculosis; Resveratrol; Small Molecule Libraries; Stilbenes