stigmasterol has been researched along with Lung-Diseases* in 1 studies
1 other study(ies) available for stigmasterol and Lung-Diseases
| Article | Year |
|---|---|
Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh).
Particulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive understanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2.5) was evaluated for its oxidative stress- and inflammation-inducing effects, which cause cell damage, in A459 human lung epithelial cells. Oxidative stress was marked by an increase in intracellular ROS levels and the production of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1). Upon induction of oxidative stress, a marked increase was observed in the expression of key inflammatory mediators such as COX-2 and PGE Topics: A549 Cells; Air Pollutants; Anti-Inflammatory Agents; Beijing; China; Epithelial Cells; Humans; Inflammation; Lung; Lung Diseases; Lung Injury; Oxidative Stress; Particulate Matter; Sargassum; Stigmasterol | 2019 |