stigmasterol has been researched along with Hypersensitivity* in 1 studies
1 other study(ies) available for stigmasterol and Hypersensitivity
| Article | Year |
|---|---|
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents.
The therapeutic potential of stigmasterol, a natural steroid alcohol with established immune-modulatory properties, was assessed on allergic cutaneous responses. We examined its suppressive effect on immunoglobulin E (IgE)-mediated active cutaneous anaphylaxis (ACA), compound 48/80 (C48/80)-induced pruritus, and irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Stigmasterol at 10-100 mg/kg significantly inhibited ACA with reduction in reaction area and concentration of the extravasated Evans blue dye. Given at 50 and 100 mg/kg, stigmasterol significantly inhibited C48/80-induced scratching behaviour when compared to saline-treated C48/80-injected control. Skin histopathology of injected sites confirmed that stigmasterol reduced mast cell trafficking and degranulation associated with C48/80-induced pruritus. Stigmasterol controlled inflammatory features such as ear skin oedema and neutrophilia and also reduced serum levels of TNF Topics: Animals; Drug Eruptions; Ghana; Hypersensitivity; Mast Cells; Mice; Mice, Inbred ICR; Rats; Rats, Wistar; Rodentia; Skin; Stigmasterol | 2018 |