stigmasterol and Cocarcinogenesis

stigmasterol has been researched along with Cocarcinogenesis* in 1 studies

Other Studies

1 other study(ies) available for stigmasterol and Cocarcinogenesis

Article	Year
Anticarcinogenicity potential of spinasterol isolated from squash flowers. Teratogenesis, carcinogenesis, and mutagenesis, 2000, Volume: 20, Issue:3 Spinasterol, an antimutagen, was isolated from squash flowers by solvent partitioning and repeated vacuum liquid chromatography. Spinasterol was then tested for its anticarcinogenic potential by using the mouse skin tumor assay. There was a 90% skin tumor incidence for the positive control group (DMBA + croton oil + acetone). At a concentration of 15.0 microg/0.2 ml acetone, spinasterol decreased the incidence of skin tumors by 55.6% and decreased the number of tumors by 65.0% when applied immediately after croton oil. Hence, spinasterol showed antitumorigenic potential. It is not a co-carcinogen nor a co-tumor promoter as there was no increase in the incidence of skin tumors after spinasterol application. Teratogenesis Carcinog. Mutagen. 20:99-105, 2000. Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chloroform; Chromatography, Liquid; Cocarcinogenesis; Croton Oil; Cucurbitaceae; Drug Screening Assays, Antitumor; Methanol; Mice; Molecular Structure; Skin Neoplasms; Solvents; Stigmasterol; Time Factors	2000

Article

Year

Anticarcinogenicity potential of spinasterol isolated from squash flowers.

Teratogenesis, carcinogenesis, and mutagenesis, 2000, Volume: 20, Issue:3

Spinasterol, an antimutagen, was isolated from squash flowers by solvent partitioning and repeated vacuum liquid chromatography. Spinasterol was then tested for its anticarcinogenic potential by using the mouse skin tumor assay. There was a 90% skin tumor incidence for the positive control group (DMBA + croton oil + acetone). At a concentration of 15.0 microg/0.2 ml acetone, spinasterol decreased the incidence of skin tumors by 55.6% and decreased the number of tumors by 65.0% when applied immediately after croton oil. Hence, spinasterol showed antitumorigenic potential. It is not a co-carcinogen nor a co-tumor promoter as there was no increase in the incidence of skin tumors after spinasterol application. Teratogenesis Carcinog. Mutagen. 20:99-105, 2000.

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chloroform; Chromatography, Liquid; Cocarcinogenesis; Croton Oil; Cucurbitaceae; Drug Screening Assays, Antitumor; Methanol; Mice; Molecular Structure; Skin Neoplasms; Solvents; Stigmasterol; Time Factors

2000