stigmasterol and Cataract

stigmasterol has been researched along with Cataract* in 1 studies

Other Studies

1 other study(ies) available for stigmasterol and Cataract

ArticleYear
Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis ex vivo.
    Archives of pharmacal research, 2010, Volume: 33, Issue:9

    Five compounds previously known structures, scopoletin (1), northalifoline (2), stigmast-4-en-3-one (3), tiliroside (4), and oplopanone (5) were obtained from the flower buds of Magnolia fargesii using chromatographic separation methods. The structures of 1-5 were identified by the interpretation of their spectroscopic data including 1D- and 2D-NMR as well as by comparison with reported values. Three compounds 1-3 were found from M. fargesii for the first time in this study. All the isolates (1-5) were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation end products formation and rat lens aldose reductase (RLAR). Compound 1 showed a remarkable inhibitory activity on advanced glycation end products formation with IC(50) value of 2.93 μM (aminoguanidine: 961 μM), and showed a significant RLAR inhibitory activity with IC(50) value of 22.5 μM (3.3-tetramethyleneglutaric acid: 28.7 μM). Compound 4 exhibited potent inhibitory activity against RLAR (IC(50) = 14.9 μM). In the further experiment ex vivo, cataractogenesis of rat lenses induced with xylose was significantly inhibited by compound 1 treatment.

    Topics: Aldehyde Reductase; Animals; Cataract; Drug Discovery; Drugs, Chinese Herbal; Enzyme Inhibitors; Flowers; Glycation End Products, Advanced; Glycosylation; Isoquinolines; Lens, Crystalline; Magnetic Resonance Spectroscopy; Magnolia; Male; Organ Culture Techniques; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Scopoletin; Stigmasterol; Time Factors

2010