stigmasterol and Carbon-Tetrachloride-Poisoning

The anti-oxidant activities of fucosterol isolated from the marine algae Pelvetia siliquosa were investigated. Fucosterol exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl4-intoxication in rats. Fucosterol inhibited the sGOT and sGPT activities by 25.57 and 63.16%, respectively. Fucosterol showed the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities by 33.89, 21.56 and 39.24%, respectively, in CCl4-intoxicated rats. These results suggest that fucosterol possess not only the anti-oxidant, but also the hepatoprotective activities in rats.

Topics: Administration, Oral; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Catalase; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Administration Schedule; Eukaryota; Glutathione Peroxidase; Hexanes; Injections, Intraperitoneal; Korea; Liver; Male; Plant Extracts; Premedication; Rats; Rats, Sprague-Dawley; Silymarin; Stigmasterol; Superoxide Dismutase; Transaminases

To study the pharmacologically active components of Eclipta prostrata.. The components were extracted by alcohol and isolated by silica gel column and subjected to pharmacological screening.. Four compounds were isolated from E. prostrata, of which two were identified as stigmasterol and alpha-terthienyl.. alpha-Terthienyl was isolated from the plant for the first time. The EtOAc part of alcoholic extraction exhibits significant hepatoprotective activity against carbon terachloride-induced liver injury in rats.

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Asteraceae; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Mice; Plants, Medicinal; Random Allocation; Stigmasterol