stephacidin-b has been researched along with Prostatic-Neoplasms* in 1 studies
1 other study(ies) available for stephacidin-b and Prostatic-Neoplasms
Article | Year |
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Stephacidin A and B: two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells.
Two novel antitumor alkaloids, Stephacidin A and B, were isolated from the solid fermentation of Aspergillus ochraceus WC76466. Both alkaloids exhibit in vitro cytotoxicity against a number of human tumor cell lines; however, stephacidin B demonstrated more potent and selective antitumor activities, especially against prostate testeosterone-dependent LNCaP cells with IC50 value of 60 nM. The structures of stephacidin A and B were established on the basis of the NMR data and X-ray crystallography. With 15 rings and 9 chiral centers, stephacidin B represents one of the most structurally complex and novel alkaloids occurring in nature. Topics: Antineoplastic Agents; Aspergillus ochraceus; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Indole Alkaloids; Indoles; Male; Molecular Structure; Neoplasms, Hormone-Dependent; Nuclear Magnetic Resonance, Biomolecular; Prostatic Neoplasms; Testosterone; Tumor Cells, Cultured | 2002 |