Page last updated: 2024-11-04

stearic acid and Innate Inflammatory Response

stearic acid has been researched along with Innate Inflammatory Response in 17 studies

octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations."9.30Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019)
"The aim of this study was to determine the relative comparability of diets enriched in palmitic acid, stearic acid, and oleic acid on inflammation and coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma cardiometabolic risk factors, and fecal bile acid concentrations."5.30Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial. ( Cohen, R; Dolnikowski, GG; Galluccio, JM; Li, L; Lichtenstein, AH; Matthan, NR; Meng, H; Rodríguez-Morató, J; Wu, D, 2019)
" Stearic acid induced significantly more EC apoptosis and necrosis than palmitic acid or myristic acids."3.76Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. ( Harvey, KA; Pavlina, TM; Siddiqui, RA; Walker, CL; Xu, Z; Zaloga, GP, 2010)
"Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric intake and energy expenditure."1.37Inflammation of the hypothalamus leads to defective pancreatic islet function. ( Araújo, EP; Boschero, AC; Calegari, VC; Morari, J; Sbragia, L; Torsoni, AS; Vanzela, EC; Velloso, LA; Zoppi, CC, 2011)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (88.24)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Maruo, S1
Kuriyama, I1
Kuramochi, K1
Tsubaki, K1
Yoshida, H1
Mizushina, Y1
Lu, H1
Guo, R1
Zhang, Y3
Su, S1
Zhao, Q1
Yu, Y1
Shi, H1
Sun, H1
Li, S1
Shi, D1
Chu, X1
Sun, C1
Wang, Y1
Balvers, MGJ1
Hendriks, HFJ1
Wilpshaar, T1
van Heek, T1
Witkamp, RF1
Meijerink, J1
Spigoni, V1
Fantuzzi, F1
Fontana, A1
Cito, M1
Derlindati, E1
Zavaroni, I1
Cnop, M1
Bonadonna, RC1
Dei Cas, A1
Meng, H1
Matthan, NR1
Wu, D1
Li, L1
Rodríguez-Morató, J1
Cohen, R1
Galluccio, JM1
Dolnikowski, GG1
Lichtenstein, AH1
Othman, AR1
Abdullah, N1
Ahmad, S1
Ismail, IS1
Zakaria, MP1
Wang, S1
Xiang, N1
Yang, L1
Zhu, C1
Zhu, X1
Wang, L1
Gao, P1
Xi, Q1
Shu, G1
Jiang, Q1
Passerini, N1
Albertini, B1
Sabatino, MD1
Corace, G1
Luppi, B1
Canistro, D1
Vivarelli, F1
Cirillo, S1
Soleti, A1
Merizzi, G1
Paolini, M1
Phua, T1
Sng, MK1
Tan, EH1
Chee, DS1
Li, Y1
Wee, JW1
Teo, Z1
Chan, JS1
Lim, MM1
Tan, CK1
Zhu, P1
Arulampalam, V1
Tan, NS1
Harvey, KA2
Walker, CL2
Pavlina, TM2
Xu, Z2
Zaloga, GP2
Siddiqui, RA2
Whitley, P1
Hise, M1
Krogmann, A1
Staiger, K1
Haas, C1
Gommer, N1
Peter, A1
Heni, M1
Machicao, F1
Häring, HU1
Staiger, H1
Calegari, VC1
Torsoni, AS1
Vanzela, EC1
Araújo, EP1
Morari, J1
Zoppi, CC1
Sbragia, L1
Boschero, AC1
Velloso, LA1
Stryjecki, C1
Roke, K1
Clarke, S1
Nielsen, D1
Badawi, A1
El-Sohemy, A1
Ma, DW1
Mutch, DM1
Watanabe, Y1
Nakamura, T1
Ishikawa, S1
Fujisaka, S1
Usui, I1
Tsuneyama, K1
Ichihara, Y1
Wada, T1
Hirata, Y1
Suganami, T1
Izaki, H1
Akira, S1
Miyake, K1
Kanayama, HO1
Shimabukuro, M1
Sata, M1
Sasaoka, T1
Ogawa, Y1
Tobe, K1
Takatsu, K1
Nagai, Y1
Anderson, EK1
Hill, AA1
Hasty, AH1
DAMMANN, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Dietary Fatty Acids on Cardiovascular Disease Risk Indicators and Inflammation.[NCT02145936]20 participants (Anticipated)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for stearic acid and Innate Inflammatory Response

ArticleYear
Comparison of diets enriched in stearic, oleic, and palmitic acids on inflammation, immune response, cardiometabolic risk factors, and fecal bile acid concentrations in mildly hypercholesterolemic postmenopausal women-randomized crossover trial.
    The American journal of clinical nutrition, 2019, 08-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Bile Acids and Salts; Cardiovascular Diseases; Cross-Over Studies; F

2019

Other Studies

16 other studies available for stearic acid and Innate Inflammatory Response

ArticleYear
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.
    Bioorganic & medicinal chemistry, 2011, Oct-01, Volume: 19, Issue:19

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; DNA Polymerase beta; Enz

2011
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression.
    Diabetes, 2021, Volume: 70, Issue:10

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Gene Expressio

2021
Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017, Volume: 1862, Issue:9

    Topics: Adult; Arachidonic Acids; Chemokine CCL20; Docosahexaenoic Acids; Fatty Acids; Female; Humans; Infla

2017
Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells.
    Atherosclerosis, 2017, Volume: 265

    Topics: Apoptosis; Cells, Cultured; Humans; Inflammation; Lipid Metabolism; Metabolic Syndrome; Monocytes; N

2017
Elucidation of in-vitro anti-inflammatory bioactive compounds isolated from Jatropha curcas L. plant root.
    BMC complementary and alternative medicine, 2015, Feb-05, Volume: 15

    Topics: Animals; Anti-Inflammatory Agents; Inflammation; Jatropha; Macrophages; Mice; Molybdenum; Palmitic A

2015
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells.
    Biochemical and biophysical research communications, 2016, Mar-18, Volume: 471, Issue:4

    Topics: Agouti-Related Protein; Animals; Eating; Hypothalamus; I-kappa B Kinase; Inflammation; Leptin; Linol

2016
Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model.
    International journal of pharmaceutics, 2016, Oct-15, Volume: 512, Issue:1

    Topics: Acetaminophen; Administration, Oral; Animals; Disease Models, Animal; Free Radical Scavengers; Glyce

2016
Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin.
    Scientific reports, 2017, 03-13, Volume: 7

    Topics: Angiopoietin-Like Protein 4; Animals; Cell Line; Chemokines; Colitis, Ulcerative; Colon; Dextran Sul

2017
Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth.
    Clinical nutrition (Edinburgh, Scotland), 2010, Volume: 29, Issue:4

    Topics: Apoptosis; Cardiovascular Diseases; Cell Adhesion; Cell Proliferation; Cell Survival; Cells, Culture

2010
Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells.
    Journal of lipid research, 2010, Volume: 51, Issue:12

    Topics: Aorta; Apoptosis; Cell Proliferation; Cells, Cultured; Dietary Fats, Unsaturated; Dose-Response Rela

2010
Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids.
    Microvascular research, 2011, Volume: 81, Issue:1

    Topics: CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Chemokine CCL20; Chemokines, CXC; Coronary Ves

2011
Inflammation of the hypothalamus leads to defective pancreatic islet function.
    The Journal of biological chemistry, 2011, Apr-15, Volume: 286, Issue:15

    Topics: Animals; Diabetes Mellitus, Type 2; Dietary Fats; Hypothalamic Diseases; Hypothalamus; Inflammation;

2011
Enzymatic activity and genetic variation in SCD1 modulate the relationship between fatty acids and inflammation.
    Molecular genetics and metabolism, 2012, Volume: 105, Issue:3

    Topics: Adult; C-Reactive Protein; Fatty Acids; Fatty Acids, Monounsaturated; Female; Genetic Variation; Gen

2012
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
    Diabetes, 2012, Volume: 61, Issue:5

    Topics: Adipocytes; Adipose Tissue; Animals; Antigens, CD; Antigens, Surface; Coculture Techniques; Dietary

2012
Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:7

    Topics: Animals; Apoptosis; Cell Polarity; Endoplasmic Reticulum Stress; Inflammation; Macrophages; Mice; Mi

2012
[Antiphlogistic percutaneous therapy with choline stearate (chomelan)].
    Die Medizinische, 1955, Feb-19, Volume: 8

    Topics: Choline; Humans; Inflammation; Stearates; Stearic Acids

1955