Page last updated: 2024-11-04

stearic acid and Hyperlipidemias

stearic acid has been researched along with Hyperlipidemias in 11 studies

octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

Hyperlipidemias: Conditions with excess LIPIDS in the blood.

Research Excerpts

ExcerptRelevanceReference
"However, the effects on postprandial lipemia and glycemia are less clear."7.01Effects of two consecutive mixed meals high in palmitic acid or stearic acid on 8-h postprandial lipemia and glycemia in healthy-weight and overweight men and postmenopausal women: a randomized controlled trial. ( Blom, WAM; Mensink, RP; Plat, J; van Rooijen, MA; Zock, PL, 2021)
"The aim of this study was to study the effect of adding polyunsaturated fatty acid (PUFA) n-3 or placebo (containing oleic acid) to a combined statin-fibrate treatment on plasma lipoproteins, lipoperoxidation, glucose homeostasis, total homocysteine (tHcy) and microalbuminuria (MA) in patients with diabetic dyslipidemia (DDL)."5.12N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. ( Písaríková, A; Stanková, B; Tvrzická, E; Vecka, M; Zák, A; Zeman, M, 2006)
"However, the effects on postprandial lipemia and glycemia are less clear."3.01Effects of two consecutive mixed meals high in palmitic acid or stearic acid on 8-h postprandial lipemia and glycemia in healthy-weight and overweight men and postmenopausal women: a randomized controlled trial. ( Blom, WAM; Mensink, RP; Plat, J; van Rooijen, MA; Zock, PL, 2021)
"The intent of this investigation was to improve pharmacokinetic (PK) and pharmacodynamic (PD) effects of Rosuvastatin calcium (RC) by solid lipid nanoparticles (SLNs)."1.46Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation. ( Dudhipala, N; Veerabrahma, K, 2017)
" This study aimed to examine the adverse effects of stearic acid on beta cells and the potential mechanisms through which these are mediated."1.43Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. ( Chen, Y; Chu, X; Cui, H; Hao, L; Li, S; Lin, S; Lu, H; Lv, L; Na, L; Sun, C; Zi, T, 2016)
"Fenofibrate lipospheres were prepared by the melt dispersion technique."1.39Formulation and optimization of fenofibrate lipospheres using Taguchi's experimental design. ( Lakshmi, PK; Saroja, C, 2013)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
van Rooijen, MA1
Plat, J1
Zock, PL1
Blom, WAM1
Mensink, RP1
Alfieri, A1
Imperlini, E1
Nigro, E1
Vitucci, D1
Orrù, S1
Daniele, A1
Buono, P1
Mancini, A1
Saroja, C1
Lakshmi, PK1
Park, KH1
Kim, JM1
Cho, KH1
Lu, H2
Hao, L1
Li, S2
Lin, S1
Lv, L1
Chen, Y1
Cui, H1
Zi, T1
Chu, X2
Na, L2
Sun, C2
Dudhipala, N1
Veerabrahma, K1
Berry, SE1
Karupaiah, T1
Tan, CH1
Chinna, K1
Sundram, K1
Liu, L1
Li, Y1
Zeman, M1
Zák, A1
Vecka, M1
Tvrzická, E1
Písaríková, A1
Stanková, B1
Titov, VN1
Arapbaeva, AA1
Kukharchuk, VV1
Balakina, MV1
Tishinin, MA1
Ameliushkina, VA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of C16:0 Versus C18:0 on HDL Metabolism and Other Cardiometabolic Risk Markers: A Dietary Intervention Study in Healthy Normal-weight and Overweight Subjects[NCT02835651]41 participants (Actual)Interventional2016-04-14Completed
Comparison of the Effect of Medium-Chain Fatty Acids and Long-Chain Fatty Acids on Postprandial Appetite and Lipemia[NCT05539742]26 participants (Actual)Interventional2022-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for stearic acid and Hyperlipidemias

ArticleYear
Effects of Plant Oil Interesterified Triacylglycerols on Lipemia and Human Health.
    International journal of molecular sciences, 2017, Dec-30, Volume: 19, Issue:1

    Topics: Dietary Fats; Fatty Acids; Humans; Hyperlipidemias; Palmitic Acid; Plant Oils; Stearic Acids; Stereo

2017
Triacylglycerol structure and interesterification of palmitic and stearic acid-rich fats: an overview and implications for cardiovascular disease.
    Nutrition research reviews, 2009, Volume: 22, Issue:1

    Topics: Adult; Animals; Coronary Disease; Diet, Atherogenic; Dietary Fats; Esterification; Humans; Hyperlipi

2009

Trials

3 trials available for stearic acid and Hyperlipidemias

ArticleYear
Effects of two consecutive mixed meals high in palmitic acid or stearic acid on 8-h postprandial lipemia and glycemia in healthy-weight and overweight men and postmenopausal women: a randomized controlled trial.
    European journal of nutrition, 2021, Volume: 60, Issue:7

    Topics: Blood Glucose; Cross-Over Studies; Dietary Fats; Female; Humans; Hyperlipidemias; Male; Meals; Overw

2021
The chain length of dietary saturated fatty acids affects human postprandial lipemia.
    Journal of the American College of Nutrition, 2011, Volume: 30, Issue:6

    Topics: Adult; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Coconut Oil; Corn Oil; Cross-Ove

2011
N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination.
    The Journal of nutritional biochemistry, 2006, Volume: 17, Issue:6

    Topics: Adult; Albuminuria; Cholesterol Esters; Clofibric Acid; Diabetes Mellitus, Type 1; Dietary Supplemen

2006

Other Studies

6 other studies available for stearic acid and Hyperlipidemias

ArticleYear
Formulation and optimization of fenofibrate lipospheres using Taguchi's experimental design.
    Acta pharmaceutica (Zagreb, Croatia), 2013, Volume: 63, Issue:1

    Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Fatty Alcohols; Feno

2013
Elaidic acid (EA) generates dysfunctional high-density lipoproteins and consumption of EA exacerbates hyperlipidemia and fatty liver change in zebrafish.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:7

    Topics: Animals; Antioxidants; Apolipoprotein A-I; Atherosclerosis; Cells, Cultured; Cholesterol Ester Trans

2014
Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway.
    Diabetologia, 2016, Volume: 59, Issue:6

    Topics: Animals; Cell Line; eIF-2 Kinase; Hyperlipidemias; Insulin; Insulin-Secreting Cells; Mice; Mice, Inb

2016
Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2017, Volume: 110

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, High Press

2017
Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia.
    Diabetes, 2013, Volume: 62, Issue:2

    Topics: Acetyl-CoA Carboxylase; Acetyltransferases; Animals; Fatty Acid Elongases; Fatty Acid Synthases; Fem

2013
[Fibrate-induced changes in the serum lipid contents of individual C16 and C18 fatty acids in patients with hyperlipidemia].
    Klinicheskaia laboratornaia diagnostika, 2006, Issue:4

    Topics: Fatty Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Linoleic Acid; Lipids; Olei

2006