Page last updated: 2024-11-04

stearic acid and Diabetes Mellitus, Adult-Onset

stearic acid has been researched along with Diabetes Mellitus, Adult-Onset in 13 studies

octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

Research Excerpts

ExcerptRelevanceReference
"We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p < 0."3.75Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. ( Dennis, AL; Frayn, KN; Harnden, KE; Hodson, L; Humphreys, SM; Micklem, KJ; Neville, MJ; Roberts, R, 2009)
"A total of 15 NIDDM patients participated in a randomized crossover study with three 3-week diet interventions separated by 2-week washout periods."2.68Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. ( Christiansen, C; Hermansen, K; Pedersen, E; Rasmussen, O; Storm, H; Thomsen, C, 1997)
"Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric intake and energy expenditure."1.37Inflammation of the hypothalamus leads to defective pancreatic islet function. ( Araújo, EP; Boschero, AC; Calegari, VC; Morari, J; Sbragia, L; Torsoni, AS; Vanzela, EC; Velloso, LA; Zoppi, CC, 2011)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's3 (23.08)29.6817
2010's7 (53.85)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Guo, R2
Yu, Y2
Zhang, Y3
Li, Y1
Chu, X2
Lu, H2
Sun, C2
Su, S1
Zhao, Q1
Shi, H1
Sun, H1
Li, S1
Shi, D1
Lin, JS2
Dong, HL1
Chen, GD1
Chen, ZY1
Dong, XW1
Zheng, JS1
Chen, YM1
Huang, L1
Aris, IM1
Yang, G1
Chen, WQ1
Li, LJ1
Sertoglu, E1
Kurt, I1
Tapan, S1
Uyanik, M1
Serdar, MA1
Kayadibi, H1
El-Fawaeir, S1
Ma, W1
Wu, JH2
Wang, Q1
Lemaitre, RN2
Mukamal, KJ1
Djoussé, L2
King, IB2
Song, X1
Biggs, ML1
Delaney, JA1
Kizer, JR1
Siscovick, DS1
Mozaffarian, D2
Zhao, L1
Ni, Y1
Ma, X1
Zhao, A1
Bao, Y1
Liu, J1
Chen, T1
Xie, G1
Panee, J1
Su, M1
Yu, H1
Wang, C1
Hu, C1
Jia, W2
Robinson, DM1
Martin, NC1
Robinson, LE1
Ahmadi, L1
Marangoni, AG1
Wright, AJ1
Roberts, R1
Hodson, L1
Dennis, AL1
Neville, MJ1
Humphreys, SM1
Harnden, KE1
Micklem, KJ1
Frayn, KN1
Calegari, VC1
Torsoni, AS1
Vanzela, EC1
Araújo, EP1
Morari, J1
Zoppi, CC1
Sbragia, L1
Boschero, AC1
Velloso, LA1
Manichaikul, A1
Guan, W1
Tanaka, T1
Foy, M1
Kabagambe, EK1
Siscovick, D1
Fretts, AM1
Johnson, C1
Psaty, BM1
McKnight, B1
Rich, SS1
Chen, YD1
Nettleton, JA1
Tang, W1
Bandinelli, S1
Jacobs, DR1
Browning, BL1
Laurie, CC1
Gu, X1
Tsai, MY1
Steffen, LM1
Ferrucci, L1
Fornage, M1
Armoni, M1
Harel, C1
Bar-Yoseph, F1
Milo, S1
Karnieli, E1
Storm, H1
Thomsen, C1
Pedersen, E1
Rasmussen, O1
Christiansen, C1
Hermansen, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Cardiovascular Health Study[NCT00005133]5,888 participants (Actual)Observational1988-06-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for stearic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis.
    Nutrients, 2019, May-01, Volume: 11, Issue:5

    Topics: Correlation of Data; Diabetes Mellitus, Type 2; Eicosanoic Acids; Fatty Acids; Humans; Incidence; My

2019

Trials

3 trials available for stearic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study.
    The American journal of clinical nutrition, 2015, Volume: 101, Issue:1

    Topics: Aged; Biomarkers; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow

2015
Influence of interesterification of a stearic acid-rich spreadable fat on acute metabolic risk factors.
    Lipids, 2009, Volume: 44, Issue:1

    Topics: Acute Disease; Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Cross-Over Studies; Diabe

2009
Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure.
    Diabetes care, 1997, Volume: 20, Issue:12

    Topics: Adult; Blood Glucose; Blood Pressure; Circadian Rhythm; Cohort Studies; Cross-Over Studies; Diabetes

1997

Other Studies

9 other studies available for stearic acid and Diabetes Mellitus, Adult-Onset

ArticleYear
Overexpression of miR-297b-5p protects against stearic acid-induced pancreatic β-cell apoptosis by targeting LATS2.
    American journal of physiology. Endocrinology and metabolism, 2020, 03-01, Volume: 318, Issue:3

    Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterifie

2020
Inhibition of lncRNA TCONS_00077866 Ameliorates the High Stearic Acid Diet-Induced Mouse Pancreatic β-Cell Inflammatory Response by Increasing miR-297b-5p to Downregulate SAA3 Expression.
    Diabetes, 2021, Volume: 70, Issue:10

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Gene Expressio

2021
Erythrocyte Saturated Fatty Acids and Incident Type 2 Diabetes in Chinese Men and Women: A Prospective Cohort Study.
    Nutrients, 2018, Oct-01, Volume: 10, Issue:10

    Topics: Adult; Aged; China; Diabetes Mellitus, Type 2; Eicosanoic Acids; Erythrocytes; Fatty Acids; Female;

2018
Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus.
    Chemistry and physics of lipids, 2014, Volume: 178

    Topics: Adult; Cell Membrane; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Erythrocyte Membrane; Fatty

2014
A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.
    Scientific reports, 2016, 06-27, Volume: 6

    Topics: 8,11,14-Eicosatrienoic Acid; Adult; Arachidonic Acid; Area Under Curve; Body Mass Index; Cardiovascu

2016
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.
    Diabetologia, 2009, Volume: 52, Issue:5

    Topics: Adipocytes; Adipose Tissue; Biopsy; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies;

2009
Inflammation of the hypothalamus leads to defective pancreatic islet function.
    The Journal of biological chemistry, 2011, Apr-15, Volume: 286, Issue:15

    Topics: Animals; Diabetes Mellitus, Type 2; Dietary Fats; Hypothalamic Diseases; Hypothalamus; Inflammation;

2011
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    Circulation. Cardiovascular genetics, 2013, Volume: 6, Issue:2

    Topics: Adult; Aged; Chromosomes, Human, Pair 2; Cohort Studies; Coronary Disease; Delta-5 Fatty Acid Desatu

2013
Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements.
    The Journal of biological chemistry, 2005, Oct-14, Volume: 280, Issue:41

    Topics: Aged; Animals; Arachidonic Acid; Biopsy; Blotting, Western; Cell Nucleus; CHO Cells; Chromatography,

2005