stearates and Multiple-Sclerosis

stearates has been researched along with Multiple-Sclerosis* in 2 studies

Other Studies

2 other study(ies) available for stearates and Multiple-Sclerosis

Article	Year
A single intrathecal injection of DNA and an asymmetric cationic lipid as lipoplexes ameliorates experimental autoimmune encephalomyelitis. Molecular pharmaceutics, 2011, Oct-03, Volume: 8, Issue:5 Intrathecal delivery of gene therapeutics is a route of administration that overcomes several of the limitations that plague current immunosuppressive treatments for autoimmune diseases of the central nervous system (CNS). Here we report intrathecal delivery of small amounts (3 μg) of plasmid DNA that codes for an immunomodulatory fusion protein, OX40-TRAIL, composed of OX40, a tumor necrosis factor receptor, and tumor necrosis factor related apoptosis inducing ligand (TRAIL). This DNA was delivered in a formulated nucleic acid-lipid complex (lipoplexes) with an asymmetric two-chain cationic lipid myristoyl (14:0) and lauroyl (12:1) rosenthal inhibitor-substituted compound (MLRI) formed from the tetraalkylammonium glycerol-based compound N-(1-(2,3-dioleoyloxy)-propyl-N-1-(2-hydroxy)ethyl)-N,N-dimethyl ammonium iodide. Delivery and expression in the CNS of OX40-TRAIL in the mouse prior to onset of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, decreased the severity of clinical disease. We believe this preclinical demonstration of rapid, widespread, and biologically therapeutic nonviral gene delivery to the CNS is important in further development of clinical lipid-based therapeutics for CNS disorders. Topics: Animals; Central Nervous System; Cisterna Magna; DNA; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Injections, Spinal; Laurates; Lipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myristates; Plasmids; Receptors, OX40; Recombinant Fusion Proteins; Stearates; TNF-Related Apoptosis-Inducing Ligand	2011
Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. Clinical chemistry, 1984, Volume: 30, Issue:3 Erythrocytes from multiple sclerosis patients differ significantly (p less than 0.005) from those from controls with regard to hydrophobic affinity partition in two-polymer aqueous-phase systems containing dextran, poly(ethylene glycol) and poly (ethylene glycol)-fatty acid esters. The most likely source of the abnormality is the cell membrane. Topics: Cell Separation; Dextrans; Erythrocyte Membrane; Erythrocytes; Humans; Linoleic Acid; Linoleic Acids; Membrane Lipids; Multiple Sclerosis; Polyethylene Glycols; Stearates	1984

Article

Year

A single intrathecal injection of DNA and an asymmetric cationic lipid as lipoplexes ameliorates experimental autoimmune encephalomyelitis.

Molecular pharmaceutics, 2011, Oct-03, Volume: 8, Issue:5

Intrathecal delivery of gene therapeutics is a route of administration that overcomes several of the limitations that plague current immunosuppressive treatments for autoimmune diseases of the central nervous system (CNS). Here we report intrathecal delivery of small amounts (3 μg) of plasmid DNA that codes for an immunomodulatory fusion protein, OX40-TRAIL, composed of OX40, a tumor necrosis factor receptor, and tumor necrosis factor related apoptosis inducing ligand (TRAIL). This DNA was delivered in a formulated nucleic acid-lipid complex (lipoplexes) with an asymmetric two-chain cationic lipid myristoyl (14:0) and lauroyl (12:1) rosenthal inhibitor-substituted compound (MLRI) formed from the tetraalkylammonium glycerol-based compound N-(1-(2,3-dioleoyloxy)-propyl-N-1-(2-hydroxy)ethyl)-N,N-dimethyl ammonium iodide. Delivery and expression in the CNS of OX40-TRAIL in the mouse prior to onset of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, decreased the severity of clinical disease. We believe this preclinical demonstration of rapid, widespread, and biologically therapeutic nonviral gene delivery to the CNS is important in further development of clinical lipid-based therapeutics for CNS disorders.

Topics: Animals; Central Nervous System; Cisterna Magna; DNA; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Gene Transfer Techniques; Genes, Reporter; Genetic Therapy; Injections, Spinal; Laurates; Lipids; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myristates; Plasmids; Receptors, OX40; Recombinant Fusion Proteins; Stearates; TNF-Related Apoptosis-Inducing Ligand

2011

Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems.

Clinical chemistry, 1984, Volume: 30, Issue:3

Erythrocytes from multiple sclerosis patients differ significantly (p less than 0.005) from those from controls with regard to hydrophobic affinity partition in two-polymer aqueous-phase systems containing dextran, poly(ethylene glycol) and poly (ethylene glycol)-fatty acid esters. The most likely source of the abnormality is the cell membrane.

Topics: Cell Separation; Dextrans; Erythrocyte Membrane; Erythrocytes; Humans; Linoleic Acid; Linoleic Acids; Membrane Lipids; Multiple Sclerosis; Polyethylene Glycols; Stearates

1984