stearates has been researched along with Glucose-Intolerance* in 1 studies
1 other study(ies) available for stearates and Glucose-Intolerance
Article | Year |
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Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
SignificanceWith obesity on the rise, there is a growing appreciation for intracellular lipid droplet (LD) regulation. Here, we show how saturated fatty acids (SFAs) reduce fat storage-inducing transmembrane protein 2 (FIT2)-facilitated, pancreatic β cell LD biogenesis, which in turn induces β cell dysfunction and death, leading to diabetes. This mechanism involves direct acylation of FIT2 cysteine residues, which then marks the FIT2 protein for endoplasmic reticulum (ER)-associated degradation. Loss of β cell FIT2 and LDs reduces insulin secretion, increases intracellular ceramides, stimulates ER stress, and exacerbates diet-induced diabetes in mice. While palmitate and stearate degrade FIT2, unsaturated fatty acids such as palmitoleate and oleate do not, results of which extend to nutrition and diabetes. Topics: Animals; Cell Line; Diabetes Mellitus; Endoplasmic Reticulum Stress; Fatty Acids; Glucose; Glucose Intolerance; Insulin-Secreting Cells; Lipid Droplets; Lipid Metabolism; Membrane Proteins; Mice; Mutation; Palmitates; Stearates | 2022 |