stearates and Glucose-Intolerance

stearates has been researched along with Glucose-Intolerance* in 1 studies

Other Studies

1 other study(ies) available for stearates and Glucose-Intolerance

ArticleYear
Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
    Proceedings of the National Academy of Sciences of the United States of America, 2022, 03-15, Volume: 119, Issue:11

    SignificanceWith obesity on the rise, there is a growing appreciation for intracellular lipid droplet (LD) regulation. Here, we show how saturated fatty acids (SFAs) reduce fat storage-inducing transmembrane protein 2 (FIT2)-facilitated, pancreatic β cell LD biogenesis, which in turn induces β cell dysfunction and death, leading to diabetes. This mechanism involves direct acylation of FIT2 cysteine residues, which then marks the FIT2 protein for endoplasmic reticulum (ER)-associated degradation. Loss of β cell FIT2 and LDs reduces insulin secretion, increases intracellular ceramides, stimulates ER stress, and exacerbates diet-induced diabetes in mice. While palmitate and stearate degrade FIT2, unsaturated fatty acids such as palmitoleate and oleate do not, results of which extend to nutrition and diabetes.

    Topics: Animals; Cell Line; Diabetes Mellitus; Endoplasmic Reticulum Stress; Fatty Acids; Glucose; Glucose Intolerance; Insulin-Secreting Cells; Lipid Droplets; Lipid Metabolism; Membrane Proteins; Mice; Mutation; Palmitates; Stearates

2022