stearates and Erythema

Skin disorders are often treated with creams containing various active substances. The creams also contain emulsifiers, which are surface-active ingredients used to stabilize the emulsion. Emulsifiers are potential irritants and in the present study the influence of stearic acid, glyceryl stearate, PEG-2, -9, -40, and -100 stearate, steareth-2, -10 and -21 on normal as well as on irritated skin have been evaluated with non-invasive measurements. Test emulsions were created by incorporating 5% emulsifiers in a water/mineral oil mixture (50:50). The emulsions and their vehicle were then applied to normal skin for 48 h and to sodium lauryl sulfate (SLS) damaged skin for 17 h in aluminum chambers. Twenty-four hours after removal of the chambers the test sites were evaluated for degree of irritation. In normal skin, the emulsifiers induced significant differences in TEWL but not in skin blood flow. Five of the emulsifiers increased TEWL. In SLS-damaged skin an aggravation of the irritation was expected. However, no differences regarding skin blood flow was noted from the emulsifiers. Furthermore, three emulsifiers unexpectedly decreased TEWL. These results highlight the possibility of absorption of these emulsifiers into the lipid bilayer, which increase TEWL in normal skin and decrease TEWL in damaged skin.

Topics: Administration, Topical; Adult; Erythema; Excipients; Female; Humans; Male; Skin; Skin Physiological Phenomena; Stearates; Structure-Activity Relationship; Surface-Active Agents

Topics: Adult; Benzenesulfonates; Body Water; Castor Oil; Dermatitis, Irritant; Drug Combinations; Epidermis; Erythema; Female; Humans; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Lipids; Male; Ointments; Permeability; Regional Blood Flow; Sebum; Siloxanes; Skin; Sodium Dodecyl Sulfate; Stearates; Waxes