stearates and Edema

An open randomized study design was used to compare the soft-tissue swelling in patients with fibular capsule injuries under therapy with Chomelanum (preparation A), Lasonil (preparation B) and ointment base of Chomelanum (preparation C). 90 patients were selected for participation in the study, and the results of 85 patients were available for evaluation. Concerning the initial condition there was no significant difference between the three therapy groups of the study. Assessment criteria were the difference of circumference in plane of ankle joint (injured/uninjured side) and the difference of soft-tissue above lateral malleoulus in sonography. The study showed that preparation A had a significantly larger influence on soft tissue detumescence than preparation B- and B larger than C. In observation period all patients of group B and C still showed soft tissue swelling. Between third and fourth day of treatment half of patients in group A did not need any treatment because of complete detumescence. In all assessment criteria significant differences in favor of preparation A were observed.

Topics: Ankle Injuries; Athletic Injuries; Choline; Drug Combinations; Edema; Heparinoids; Humans; Hyaluronoglucosaminidase; Ligaments, Articular; Ointments; Stearates

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that can effectively control the pain and inflammation caused by rheumatoid arthritis (RA), but its usage is limited due to severe adverse effects. For this reason, making more specific formulations of this drug can be considered. The aim of the present study was designing a novel nano-sized indomethacin delivery system.. Indomethacin-loaded dextran stearate polymeric micelles were prepared by dialysis method. Particle size and zeta potential of micelles were measured by a zeta sizer instrument. Drug release from micelles was investigated in phosphate buffer medium pH 7.4 and then the best formulation regarding physical properties and drug release was selected for animal studies. Arthritis was induced by complete Freund's adjuvant injection in rats. Then, the animals were randomly assigned into the model, the indomethacin solution and the polymeric micelles groups. The clinical effects of polymeric micelle formulation were assessed by measuring arthritis index, animal paw edema and measuring biochemical parameters including myeloperoxidase (MPO) activity, lipid peroxidation (LPO), glutathione (GSH), total antioxidant capacity (TAC), TNF-α, IL-17 and IL-1β.. Paw edema was attenuated following the administration of indomethacin-loaded polymeric micelles. Based on the findings of the present study, the use of indomethacin-loaded polymeric micelles could improve inflammatory symptoms, decrease arthritis index and decrease the diameter of the paw in arthritic rats in a significant manner (p ≤ 0.05). In addition, the use of polymeric micelles like indomethacin solution significantly reduced (p ≤ 0.05) the activity of MPO, LPO, TNF-α, IL-17 and IL-1β, and made a significant increase (p ≤ 0.05) in glutathione and TAC content and ameliorated structural changes in the paw tissue compared to the control group.. Our findings demonstrated that indomethacin-loaded dextran stearate polymeric micelles can provide more effective therapeutic effects in control of inflammation in arthritis in rat.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dextrans; Drug Delivery Systems; Drug Liberation; Edema; Freund's Adjuvant; Indomethacin; Inflammation; Male; Micelles; Polymers; Rats; Rats, Wistar; Stearates