stearates and Colitis

Data from clinical research suggest that certain probiotic bacterial strains have the potential to modulate colonic inflammation. Nonetheless, these data differ between studies due to the probiotic bacterial strains used and the poor knowledge of their mechanisms of action.. By mass-spectrometry, we identified and quantified free long chain fatty acids (LCFAs) in probiotics and assessed the effect of one of them in mouse colitis.. Among all the LCFAs quantified by mass spectrometry in. The production of C18-3OH by bacteria could be one of the mechanisms implicated in the anti-inflammatory properties of probiotics. The production of LCFA-3OH by bacteria could be implicated in the microbiota/host interactions.

Topics: Animals; Bacteroidetes; Caco-2 Cells; Cell Membrane Permeability; Chemokine CXCL1; Colitis; Dextran Sulfate; Epithelial Cells; Escherichia coli; Firmicutes; Gastrointestinal Microbiome; Gene Expression; Humans; Interleukin-1beta; Intestinal Mucosa; Mass Spectrometry; Mice; Oligosaccharides; Pancreatitis-Associated Proteins; Permeability; Peyer's Patches; PPAR gamma; Prebiotics; Probiotics; Stearates; Zonula Occludens-1 Protein