staurosporine has been researched along with Neuroblastoma in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 56 (40.88) | 18.2507 |
| 2000's | 59 (43.07) | 29.6817 |
| 2010's | 21 (15.33) | 24.3611 |
| 2020's | 1 (0.73) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, Z; Hu, Y; Li, J; Lv, D; Xu, G; Ye, Q | 1 |
| Abou Mansour, E; Alonso, E; Alvariño, R; Banaigs, B; Bonnard, I; Bornancin, L; Botana, L; Burja, AM; Genevière, AM; Levert, A | 1 |
| Angeles, C; Enzor, LA; Levesque, AA; Pappalardo, RM; Puli, P | 1 |
| Bleackley, RC; Buggia-Prévot, V; Kar, S; MacDonald, RG; Thinakaran, G; Wang, Y; Zavorka, ME | 1 |
| Jantas, D; Lason, W; Piotrowski, M | 1 |
| Beltramini, M; Bisaglia, M; Bubacco, L; Civiero, L; Codolo, G; Ferrari, V; Filograna, R; Greggio, E | 1 |
| Budziszewska, B; Krzyżanowska, W; Muszyńska, B; Pomierny, B; Szewczyk, A; Łojewski, M | 1 |
| Li, QX; Liang, Z; Su, WW; Williams, PG; Zhang, B | 1 |
| Asif, AR; Behrens, C; Dihazi, H; Ramljak, S; Schmitz, M; Schulz-Schaeffer, WJ; Zafar, S; Zerr, I | 1 |
| Goubaeva, F; Lee, HT; Mikami, M; Song, JH; Yang, J | 1 |
| Araki, Y; Hara, H; Izuta, H; Mishima, S; Shimazawa, M; Tazawa, S | 1 |
| Blackstone, C; Bouchard, RJ; Brewster, JL; Hilger, S; Kelsey, NA; Linseman, DA; Loucks, FA; Schroeder, EK; Zommer, AE | 1 |
| Anderson, E; Brown, R; Forster, S; Gibson, GG; Lyon, J; Plant, KE; Plant, N; Simecek, N; Spinks, J; Toms, N | 1 |
| Jahnke, HG; Kurz, RG; Mack, TG; Pänke, O; Robitzki, AA; Rothermel, A; Sternberger, I; Striggow, F | 1 |
| Emmanouilidou, E; Stefanis, L; Vekrellis, K; Xilouri, M | 1 |
| Allerhand, M; Deighton, RF; Kerr, LE; McCulloch, J; Short, DM; Whittle, IR | 1 |
| Li, HL; Liao, K; Liu, R; Liu, SJ; Wang, HH; Wang, JZ; Wang, Q; Zhang, Y | 1 |
| Hattori, N; Kawajiri, S; Machida, Y; Saiki, S; Sato, S | 1 |
| Ambing, E; Chen, C; Gao, MY; Harris, JL; Hua, S; Jia, Y; Kim, S; Lee, CC; Lesley, SA; Li, N; Michellys, PY; Ng, K; Spraggon, G; Sun, X | 1 |
| Basta-Kaim, A; Budziszewska, B; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Lipkowski, AW | 1 |
| Barrier, L; Fauconneau, B; Hubert, C; Ingrand, S; Noël, A; Rinaldi, F | 1 |
| Anderson, RL; Cheng, L; Nagley, P; Smith, DJ | 1 |
| Amadoro, G; Atlante, A; Bussani, R; Calissano, P; Capsoni, S; Corsetti, V; Florenzano, F; Mercanti, D | 1 |
| Armstrong, EJ; Brooks, BR; Hemendinger, RA; Radio, N | 1 |
| Gleinich, A; Lau, H; Li, G; Zimmermann, M | 1 |
| Emanuelsson, I; Norlin, M | 1 |
| Faden, AI; Hanscom, M; Piao, CS; Sabirzhanov, B; Stoica, BA | 1 |
| Das, G; Jagtap, JC; Mruthyunjaya, S; Pujari, R; Shah, RD; Shastry, P; Shelke, GV | 1 |
| Jackson, TC; Kochanek, PM; Verrier, JD | 1 |
| Akbar, M; Kim, HY | 1 |
| Ambrosio, S; Barrachina, M; Ferrer, I; Gómez-Santos, C; Lozano, R; Secades, J | 1 |
| Peng, FF; Wu, DC; Zhang, BF; Zhang, JZ | 2 |
| Merkler, D; Oertle, T; Schwab, ME | 1 |
| Akbar, M; Kim, HY; Lau, A | 1 |
| Agathanggelou, A; Ahmed-Choudhury, J; Baksh, S; Bièche, I; Dammann, R; Downward, J; Gao, B; Latif, F; Maher, ER; Minna, JD; Nicke, B | 1 |
| Ariga, H; Ito, K; Mizusawa, H; Sugawara, K; Takahashi, R; Yokota, T | 1 |
| Krupski, M; Mani, S; O'Guin, K; Okwuaka, C; Parashar, B; Shafit-Zagardo, B; Shankar, SL | 1 |
| Dolcini, V; Genova, F; Mueller, U; Nizzari, M; Repetto, E; Russo, C; Salis, S; Schettini, G; Venezia, V | 1 |
| Hsieh, M; Tsai, HF; Tsai, HJ | 1 |
| Beierle, EA; Chen, MK; Dai, W; Iyengar, M; Nagaram, A | 1 |
| Aguirre, N; Ceña, V; Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, M; González-García, C; Jordán, J | 1 |
| Cheetham, ME; Guzhova, IV; Margulis, BA; Novoselov, SS; Novoselova, TV; Sapozhnikov, AM; van der Spuy, J | 1 |
| Lodish, HF; Um, M | 1 |
| Auberger, P; Checler, F; da Costa, CA; Giaime, E; Grosso, S; Herrant, M; McLean, PJ; Sunyach, C | 1 |
| Leirós, CP; Nesse, A; Pérez, G; Pregi, N; Vittori, D | 1 |
| Ankarcrona, M; Cedazo-Minguez, A; Hansson, CA; Laudon, H; Popescu, BO; Popescu, LM; Winblad, B | 1 |
| Cho, S; Park, EM | 1 |
| Gross, AW; Lodish, HF; Um, M | 1 |
| Han, CT; Kim, SJ; Kim, YC; Markelonis, GJ; Oh, TH; Oh, YJ; Yune, TY | 1 |
| Beard, JL; Buwen, JP; Cifelli, CJ; Jones, BC; Unger, EL; Wiesinger, JA | 1 |
| Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V | 1 |
| Johnson, GV; Jope, RS; Mookherjee, P; Quintanilla, R; Roh, MS; Zmijewska, AA | 1 |
| Mollereau, C; Roumy, M; Zajac, JM | 1 |
| Birse-Archbold, JL; Heron, ID; Kerr, LE; McCulloch, J; Sharkey, J; Short, DM | 1 |
| Billett, EE; De Girolamo, LA; Fitzgerald, JC; Kuhn, H; Ufer, C | 1 |
| Basta-Kaim, A; Budziszewska, B; Jagla, G; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Nowak, W; Regulska, M | 1 |
| Dauer, WT; Fink, JS; Hamill, LK; Hyman, SE; Lewis, SE; Schwarzschild, MA | 1 |
| Couldwell, WT; Hintona, DR; Lawa, RE; Su, Y; Zhang, W | 1 |
| Adachi, I; Sasaki, K; Tsukada, T; Yamaguchi, K | 1 |
| Rebhan, M; Rösner, H; Vacun, G | 1 |
| Alling, C; Larsson, C; Simonsson, P | 1 |
| Belayew, A; Bulens, F; Collen, D; De Vriese, A; Ibañez-Tallon, I; Nelles, L; Van Acker, P | 1 |
| Connors, TJ; Hudkins, R; Knight, E; Maroney, AC; Neff, N | 1 |
| Burns, P; Chatterjee, S; Koga, J | 1 |
| Baumgold, J; Curran, P; Fishman, PH; Zhou, XM | 1 |
| Jalava, A; Mai, S | 1 |
| Audette, M; Bouillon, M | 1 |
| Osda, H | 1 |
| Larsson, C; Simonsson, P | 1 |
| Herman, MD; Narahashi, T; Reuveny, E | 1 |
| Fowler, CJ; Martinsson, T | 1 |
| Akerman, K; Heikkilä, J; Jalava, A | 1 |
| Dawson, G; Wiesner, DA | 1 |
| Itano, Y; Nomura, Y | 1 |
| Maruyama, K; Nishimura, E; Sasaki, K; Tsukada, T; Yamaguchi, K | 2 |
| Farlow, MR; Lahiri, DK | 1 |
| Maruyama, K; Sasaki, K; Tsukada, T; Yamaguchi, K | 1 |
| Arbuckle, J; Boddeke, HW; Boeijinga, P; Docherty, RJ; Meigel, I | 1 |
| Artemenko, IP; Hokin, LE; Los, GV | 1 |
| Allen, H; Gilbertsen, RB; Hajimohammadreza, I; Nath, R; Posner, A; Raser, KJ; Stafford, D; Talanian, RV; Wang, KK; Yuen, P | 1 |
| Chan, SL; Ronca, F; Yu, VC | 1 |
| Akerman, KE; Courtney, MJ; Kukkonen, JP; Shariatmadari, R | 1 |
| Gilbertsen, RB; McGinnis, K; Nadimpalli, R; Posmantur, R; Wang, KK | 1 |
| Hadac, EM; Miller, LJ; Rao, RV; Roettger, BF | 1 |
| Dawson, G; Dawson, SA; Goswami, R | 1 |
| Boix, J; Comella, JX; Llecha, N; Yuste, VJ | 1 |
| Oreland, L; Prince, JA | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Maurelli, S | 1 |
| Kamoshima, W; Kitamura, Y; Nomura, Y; Shimohama, S; Taniguchi, T | 1 |
| Hishiki, T; Hiwasa, T; Kondo, K; Koshizawa, S; Nakagawara, A; Umezawa, K | 1 |
| Beckman, M; Hallberg, E; Imreh, G; Iverfeldt, K | 1 |
| Borchelt, DR; Cooper, JK; Dawson, TM; Dawson, VL; Delanoy, M; Herring, WJ; Kaminsky, Z; Khan, FA; Masone, J; Peters, MF; Ross, CA; Schilling, G; Sharp, AH | 1 |
| Jänicke, RU; Porter, AG; Sprengart, ML; Wati, MR | 1 |
| Gnegy, ME; McGinnis, KM; Wang, KK; Whitton, MM | 1 |
| Edwards, AD; Greenwood, K; Joashi, UC; Kozma, M; Mazarakis, ND; Mehmet, H; Taylor, DL | 1 |
| Chakravarthy, BR; Hill, IE; MacManus, JP; Rasquinha, I; Walker, T | 1 |
| Gnegy, ME; McGinnis, KM; Wang, KK | 1 |
| Jagtap, JC; Krishna, M; Mohan, DR; Nagarathna, R; Shastry, P | 1 |
| Tieu, K; Yu, PH; Zuo, DM | 1 |
| Jenkins, SM; Johnson, GV | 1 |
| Garner, C; Jenkins, SM; Johnson, GV; Zinnerman, M | 1 |
| Bijur, GN; De Sarno, P; Jope, RS | 1 |
| Burger, MM; Dagan, D; Hagmann, J | 1 |
| Berman, SA; Bursztajn, S; Feng, JJ; Nanda, A | 2 |
| Haug, LS; Ostvold, AC; Walaas, SI | 1 |
| François, F; Godinho, MJ; Grimes, ML | 1 |
| Ferrer, I; López, E | 1 |
| Billardon, C; Carvajal-Gonzalez, S; Gompel, A; Kandouz, M; Lombet, A; Rostène, W; Zujovic, V | 1 |
| Leung, HW; Leung, KN; Lung, HL; Mak, NK; Tsang, HY; Wong, RN | 1 |
| Armato, U; Costantini, C; Dal-Pra, I; Della Valle, G; Della-Bianca, V; Perini, G; Politi, V; Rossi, F | 1 |
| Bahamonde, MI; Diaz, M; Hardy, SP; Lock, H; Muñoz, FJ; Posas, F; Valverde, MA | 1 |
| Cho, S; Dawson, G; Dawson, PE | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Nguyen, HN; Perry, DC; Wang, C | 1 |
| Bayascas, JR; Boix, J; Comella, JX; Encinas, M; Sánchez-López, I; Solé, C; Yuste, VJ | 1 |
| Bruey, JM; Castedo, M; Costantini, P; Garrido, C; Kroemer, G; Loeffler, M; Métivier, D; Ravagnan, L; Susin, SA; Zamzami, N | 1 |
| Kayama, T; Kitanaka, C; Kokubu, A; Kuchino, Y; Sakurada, K; Sunayama, J; Tomiyama, A | 1 |
| Grenet, J; Kidd, VJ; Lahti, JM; Liu, D; Teitz, T; Valentine, M; Valentine, V; Wei, T | 1 |
| Ceña, V; Gonzalez, C; Lamas, M; Mellström, B; Naranjo, JR; Perales, C | 1 |
| Chun, W; Johnson, GV; Lee, M; Lesort, M | 1 |
| Chang, CH; Glasebrook, AL; Kovacevic, S; Mosior, M; Na, S; Racke, MM; Roehm, NW | 1 |
| Ambrosio, S; Barrachina, M; Ferrer, I; Gómez-Santos, C; Reiriz, J; Viñals, F | 1 |
| Johnson, GV; Tucholski, J | 1 |
| Fiander, H; O'Reilly, N; Small, DL; Tauskela, J; Xia, Z | 1 |
| Hemmings, BA; Monard, D; Stone, SR; Suidan, HS | 1 |
| Jalink, K; Moolenaar, WH | 1 |
| Beermann, ML; Leli, U; Nixon, RA; Shea, TB | 1 |
| al-Mazidi, H; Gregor, A; Lach, B; Proulx, P; Slack, R | 1 |
| Cataldo, A; Hauser, G; Leli, U; Nixon, RA; Shea, TB | 1 |
| Felipo, V; Grisolía, S; Llopis, J; Miñana, MD; Romá, J; Romero, FJ | 1 |
| Burgess, GM; Coote, PR; Dunn, PM; Rang, HP; Wood, JN | 1 |
| Sandmann, J; Wurtman, RJ | 1 |
| Beermann, ML; Shea, TB | 1 |
| Proulx, P; Slack, RS | 1 |
1 review(s) available for staurosporine and Neuroblastoma
| Article | Year |
|---|---|
[Differentiation inducing compounds].
Topics: Acetylcysteine; Alkaloids; Animals; Anthraquinones; Blood Cells; Cell Differentiation; Cells, Cultured; Humans; Leukemia, Experimental; Neuroblastoma; Purine Nucleosides; Ribonucleosides; Sesquiterpenes; Staurosporine | 1993 |
136 other study(ies) available for staurosporine and Neuroblastoma
| Article | Year |
|---|---|
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3beta (GSK-3beta) inhibitors.
Topics: Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Maleimides; Models, Molecular; Neuroblastoma; Phosphorylation; Structure-Activity Relationship; tau Proteins | 2009 |
Structures and Activities of Tiahuramides A-C, Cyclic Depsipeptides from a Tahitian Collection of the Marine Cyanobacterium Lyngbya majuscula.
Topics: Anti-Bacterial Agents; Aquatic Organisms; Cell Death; Cell Line, Tumor; Cyanobacteria; Cytotoxins; Depsipeptides; Humans; Marine Biology; Neuroblastoma | 2018 |
p53 oligomerization status as an indicator of sensitivity of p53-wildtype neuroblastomas to the combination of DNA damaging agent and Chk1 inhibitor.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Genes, p53; Humans; Irinotecan; Neuroblastoma; Staurosporine; Topoisomerase I Inhibitors | 2022 |
Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Survival; Endosomes; Enzyme Inhibitors; Fibroblasts; Humans; Lysosomes; Mice; Microscopy, Fluorescence; Neuroblastoma; Receptor, IGF Type 2; RNA Interference; Staurosporine; Transfection | 2015 |
An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Calpain; Cell Line, Tumor; Chromones; Doxorubicin; Humans; Morpholines; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Undecylenic Acids | 2015 |
Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation.
Topics: Catecholamines; Cell Differentiation; Cell Line, Tumor; Humans; Neuroblastoma; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin | 2015 |
Protective Effects of Bacopa Monnieri on Hydrogen Peroxide and Staurosporine: Induced Damage of Human Neuroblastoma SH-SY5Y Cells.
Topics: Bacopa; Cell Line, Tumor; Humans; Hydrogen Peroxide; Neuroblastoma; Neuroprotective Agents; Plant Extracts; Staurosporine | 2016 |
C-Glycosylflavones Alleviate Tau Phosphorylation and Amyloid Neurotoxicity through GSK3β Inhibition.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycogen Synthase Kinase 3; Humans; Isoflavones; Luteolin; Models, Chemical; Neuroblastoma; Peptide Fragments; Phosphorylation; Signal Transduction; Staurosporine; tau Proteins | 2016 |
Cellular prion protein mediates early apoptotic proteome alternation and phospho-modification in human neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation; Humans; Neuroblastoma; Neurons; Phosphorylation; Prion Proteins; Profilins; Proteome; Staurosporine; Transfection | 2017 |
beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells.
Topics: Adrenergic beta-Antagonists; Apoptosis; Atenolol; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Cytochromes c; Cytoprotection; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Situ Nick-End Labeling; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neuroblastoma; Neurons; Poly(ADP-ribose) Polymerases; Propanolamines; Propranolol; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine; Time Factors | 2008 |
Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum; Enzyme Activation; Flavonoids; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Neurons; Propolis; Staurosporine; Tunicamycin | 2008 |
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.
Topics: Animals; Apoptosis; Brain; Caspase 3; Caspase 8; Caspase Inhibitors; Caspases; Cells, Cultured; Cerebellum; Cytochromes c; Digitonin; GTP Phosphohydrolases; Humans; Mitochondria; Neuroblastoma; Neurons; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine | 2009 |
The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.
Topics: Antimanic Agents; Apoptosis; Cell Line, Tumor; Gene Expression Profiling; Gene Silencing; Homeodomain Proteins; Humans; Lithium Chloride; Neuroblastoma; Staurosporine; Up-Regulation; Valproic Acid | 2009 |
An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells.
Topics: Analysis of Variance; Carbazoles; Cell Line, Tumor; Electric Impedance; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Laminin; Microchip Analytical Procedures; Microelectrodes; Neuroblastoma; Okadaic Acid; Phosphorylation; Staurosporine; tau Proteins | 2009 |
Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.
Topics: alpha-Synuclein; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Inositol; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Staurosporine; Time Factors; Transfection; Tretinoin | 2009 |
Network generation enhances interpretation of proteomic data from induced apoptosis.
Topics: Apoptosis; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Humans; Neuroblastoma; Protein Folding; Protein Interaction Mapping; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine | 2010 |
Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.
Topics: Animals; Annexin A5; Apoptosis; beta Catenin; Camptothecin; Caspase 3; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; Hippocampus; Humans; Maytansine; Mice; Mice, Transgenic; Mutation; Neuroblastoma; RNA, Small Interfering; Staurosporine; Subcellular Fractions; tau Proteins; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2010 |
Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antioxidants; Apoptosis; Caspases; Cell Differentiation; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; In Situ Nick-End Labeling; Isoxazoles; Neuroblastoma; Neurotoxins; Staurosporine; Superoxide Dismutase; Up-Regulation; Zonisamide | 2010 |
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
Topics: Adenosine Diphosphate; Amino Acid Motifs; Amino Acid Sequence; Anaplastic Lymphoma Kinase; Animals; Catalytic Domain; Cell Line; Crystallization; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutant Proteins; Neuroblastoma; Phosphorylation; Protein Binding; Protein Conformation; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Sequence Homology, Amino Acid; Spodoptera; Staurosporine; Substrate Specificity | 2010 |
Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Differentiation; Cell Line, Tumor; Convulsants; Cytotoxins; Homocysteine; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Neuroblastoma; Neuroprotective Agents; Nitro Compounds; Oxidants; Phosphatidylinositol 3-Kinases; Propionates; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Thyrotropin-Releasing Hormone; Tretinoin | 2010 |
Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3β/Tyr216, resulting in glycogen synthase kinase 3β activation in SH-SY5Y human neuroblastoma cell lines.
Topics: Antimanic Agents; Cell Line, Tumor; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lithium Chloride; Neuroblastoma; Neurons; Phosphorylation; Staurosporine | 2011 |
Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.
Topics: Apoptosis; Cell Differentiation; Cell Line, Tumor; Heating; HSP72 Heat-Shock Proteins; Humans; Neuroblastoma; Neurons; Staurosporine | 2011 |
Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration.
Topics: Adenine Nucleotide Translocator 1; Adenosine Diphosphate; Adenosine Triphosphate; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Brain; Cells, Cultured; Cerebellum; Cyclophilins; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Female; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Lewy Body Disease; Male; Membrane Proteins; Middle Aged; Mitochondria; Neuroblastoma; Neurons; Parkinson Disease; Peptide Fragments; Rats; Rats, Wistar; Receptors, AMPA; Staurosporine; Subcellular Fractions; Synapses; Synaptosomes; tau Proteins | 2012 |
Neurotoxic injury pathways in differentiated mouse motor neuron-neuroblastoma hybrid (NSC-34D) cells in vitro--limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Calcium; Caspase 3; Caspase 7; Cell Line; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Homocysteine; Hybrid Cells; Hydrogen Peroxide; Mice; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Neurotoxins; Riluzole; Staurosporine; Thapsigargin | 2012 |
Staurosporine-induced apoptosis presents with unexpected cholinergic effects in a differentiated neuroblastoma cell line.
Topics: Acetylcholinesterase; Apoptosis; Blotting, Western; Caspase 3; Cell Differentiation; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Phosphorylation; Receptors, Cholinergic; Staurosporine | 2012 |
Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Differentiation; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; Hydroxycholesterols; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Staurosporine | 2012 |
Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Etoposide; Gene Expression Regulation; Green Fluorescent Proteins; HSP70 Heat-Shock Proteins; Humans; Immunoprecipitation; Neural Inhibition; Neuroblastoma; Neurons; Peptide Fragments; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Rats; Signal Transduction; Sphingosine; Staurosporine; Transfection | 2012 |
Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; Neuroblastoma; Proteolysis; Proto-Oncogene Proteins c-akt; Pyridines; Staurosporine; Survivin; Valproic Acid | 2013 |
Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent.
Topics: Animals; Anthraquinones; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Chromones; Emodin; Hydrogen Peroxide; Lipid Peroxidation; Morpholines; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Staurosporine | 2013 |
Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Cytoprotection; Docosahexaenoic Acids; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Mice; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphatidylserines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Time Factors; Tumor Cells, Cultured | 2002 |
Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Death; Cell Line; Cytidine Diphosphate Choline; Enzyme Inhibitors; Glutathione; Humans; Neuroblastoma; Nootropic Agents; Oxidation-Reduction; Staurosporine; Tumor Cells, Cultured | 2002 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine | 2002 |
Do cancer cells die because of Nogo-B?
Topics: Animals; Apoptosis; Bone Neoplasms; Cell Division; CHO Cells; Cricetinae; Cricetulus; Endoplasmic Reticulum; Gene Expression Regulation; Humans; Myelin Proteins; Neoplasm Proteins; Neuroblastoma; Nogo Proteins; Osteosarcoma; Rats; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Cells, Cultured; Tunicamycin | 2003 |
Effects of docosapentaenoic acid on neuronal apoptosis.
Topics: Animals; Apoptosis; Caspases; Cell Line, Tumor; Cytoprotection; Docosahexaenoic Acids; Fatty Acids; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Phosphatidylserines; Proto-Oncogene Proteins c-raf; Staurosporine; Tissue Distribution | 2003 |
Staurosporine induces apoptosis in NG108-15 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; DNA Fragmentation; Enzyme Inhibitors; Glioma; Hybrid Cells; Mice; Neuroblastoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Staurosporine; Tumor Cells, Cultured | 2003 |
Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cyclin D1; Down-Regulation; G1 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Neoplasm Proteins; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Down-Regulation; Endoplasmic Reticulum; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Kidney; Mice; Multienzyme Complexes; Mutation; Neuroblastoma; Oncogene Proteins; Oxidative Stress; Proteasome Endopeptidase Complex; Protein Deglycase DJ-1; Recombinant Proteins; Staurosporine; Structure-Activity Relationship | 2003 |
UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines.
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Nervous System Neoplasms; Neuroblastoma; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Survivin; X-Linked Inhibitor of Apoptosis Protein | 2004 |
Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Antibodies, Monoclonal; Apoptosis; Aspartic Acid Endopeptidases; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; GRB2 Adaptor Protein; Green Fluorescent Proteins; Humans; Luminescent Proteins; Neuroblastoma; Peptide Fragments; Precipitin Tests; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Staurosporine; Time Factors | 2004 |
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
Topics: Apoptosis; Ataxin-3; Cell Line, Tumor; Cytochromes c; Fibroblasts; Humans; Machado-Joseph Disease; Mitochondria; Nerve Tissue Proteins; Neuroblastoma; Neurons; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Staurosporine; Trinucleotide Repeat Expansion | 2004 |
VEGF-mediated survivin expression in neuroblastoma cells.
Topics: Apoptosis; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Morpholines; Neoplasm Proteins; Neuroblastoma; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; Survivin; Vascular Endothelial Growth Factor A | 2005 |
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions.
Topics: Animals; Calcium; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Membrane Potentials; Minocycline; Mitochondria; Mitochondrial Swelling; NADP; Neuroblastoma; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spectrophotometry; Staurosporine; Tetrazolium Salts; Thiazoles | 2005 |
Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation.
Topics: Animals; Apoptosis; Blotting, Western; Caspases; Cattle; Cell Aggregation; Cell Count; Cell Line, Tumor; Cell Size; Dose-Response Relationship, Drug; Drug Interactions; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flow Cytometry; Green Fluorescent Proteins; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Indoles; Microscopy, Confocal; Neuroblastoma; Peptides; Staurosporine; Time Factors; Transfection; Trinucleotide Repeat Expansion | 2005 |
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Erythropoietin; Extracellular Signal-Regulated MAP Kinases; Humans; Mitogen-Activated Protein Kinases; Neuroblastoma; Prolactin; Proto-Oncogene Proteins c-akt; Receptors, Erythropoietin; Receptors, Prolactin; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Transcription Factor RelA | 2006 |
Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.
Topics: Adrenergic Agents; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cells, Cultured; Enzyme Inhibitors; Humans; Kidney; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidopamine; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Signal Transduction; Staurosporine; Transcription, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53 | 2006 |
Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells.
Topics: Apoptosis; bcl-X Protein; Blotting, Western; Cell Differentiation; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Inhibitors; Erythropoietin; Humans; Kinetics; Microscopy, Fluorescence; Neuroblastoma; Precipitin Tests; Receptors, Erythropoietin; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine | 2006 |
Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Apoptosis; Aspartic Acid Endopeptidases; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Chromatin; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoprecipitation; Luciferases; Membrane Proteins; Multiprotein Complexes; Mutation; Neuroblastoma; Peptide Fragments; Presenilin-1; Protein Structure, Tertiary; Staurosporine; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2006 |
Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE(2)C cells.
Topics: Analysis of Variance; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Cell Line, Tumor; Colforsin; Collagen Type XI; CREB-Binding Protein; Dopamine; Drug Interactions; Enzyme Inhibitors; Humans; Mitogen-Activated Protein Kinases; Neuroblastoma; Nitriles; Staurosporine | 2006 |
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells.
Topics: Animals; Apoptosis; Binding Sites; Cell Differentiation; Cell Line, Tumor; Enzyme Inhibitors; Erythropoietin; Humans; Neuroblastoma; PC12 Cells; Rats; Receptors, Erythropoietin; RNA, Small Interfering; Staurosporine | 2007 |
Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH-SY5Y cells against oxidative stress.
Topics: Antioxidants; Caspase 3; Cell Death; Cell Line, Tumor; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; Indoles; Isocitrate Dehydrogenase; Membrane Potential, Mitochondrial; Mitochondria; NADP; Neuroblastoma; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Proteins; Staurosporine; Transfection | 2007 |
Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis.
Topics: Animals; Biotinylation; Blotting, Western; Cell Line; Deferoxamine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Humans; Leucine; Neuroblastoma; Protein Kinase C; Protein Transport; Rats; RNA, Messenger; Siderophores; Staurosporine; Subcellular Fractions; Time Factors; Transfection; Tritium | 2007 |
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors | 2007 |
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.
Topics: Amino Acid Sequence; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Sequence Data; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protein Sorting Signals; Proto-Oncogene Proteins c-akt; Staurosporine | 2007 |
Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.
Topics: Calcium; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Neuroblastoma; Neuropeptide Y; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid; Staurosporine | 2007 |
Apoptosis induced by staurosporine alters chaperone and endoplasmic reticulum proteins: Identification by quantitative proteomics.
Topics: Apoptosis; Cell Line, Tumor; Electrophoresis, Gel, Two-Dimensional; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Chaperones; Neuroblastoma; Peptide Mapping; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staurosporine | 2007 |
Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Dopamine; Enzyme Inhibitors; Humans; MAP Kinase Signaling System; Mitochondria; Monoamine Oxidase; Neuroblastoma; Neurons; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Staurosporine; Up-Regulation | 2007 |
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Pregnanolone; Pregnenolone; Staurosporine; Steroids | 2008 |
Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Blotting, Western; Carbazoles; Cell Line; Cells, Cultured; Ciliary Neurotrophic Factor; Cytokines; Growth Inhibitors; Indole Alkaloids; Interleukin-6; Isoquinolines; Leukemia Inhibitory Factor; Lymphokines; Nerve Growth Factors; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oncostatin M; Peptides; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; ras Proteins; Rats; RNA; RNA, Messenger; Staurosporine; Superior Cervical Ganglion; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C.
Topics: Alkaloids; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Division; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Inhibitors; Humans; In Vitro Techniques; Neuroblastoma; Perylene; Protein Kinase C; Staurosporine; Tamoxifen; Tumor Cells, Cultured | 1995 |
Staurosporine potentiates cAMP-mediated promoter activity of the vasoactive intestinal polypeptide gene in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; beta-Galactosidase; Colforsin; Cyclic AMP; Enzyme Inhibitors; Humans; Kinetics; Neurites; Neuroblastoma; PC12 Cells; Pheochromocytoma; Promoter Regions, Genetic; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Transfection; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1995 |
Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C.
Topics: Acetylcholine; Actins; Alkaloids; Carbachol; Cell Size; Culture Media; Cytochalasin B; Fluorescent Dyes; Humans; Indoles; Maleimides; Neurites; Neuroblastoma; Protein Kinase C; Receptors, Muscarinic; Receptors, Nicotinic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Calcium; Cell Membrane Permeability; Diglycerides; Ethers, Cyclic; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Myelin Basic Protein; Neoplasm Proteins; Neuroblastoma; Okadaic Acid; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein Phosphatase 2; Protein Processing, Post-Translational; Signal Transduction; Staurosporine; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Retinoic acid induction of human tissue-type plasminogen activator gene expression via a direct repeat element (DR5) located at -7 kilobases.
Topics: Alkaloids; Animals; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; DNA; Dose-Response Relationship, Drug; Endothelium; Enzyme Induction; Fibrosarcoma; Gene Expression; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Mutagenesis; Neuroblastoma; Oligodeoxyribonucleotides; Protein Kinase C; Protein Multimerization; Rats; Receptors, Retinoic Acid; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptors; Sequence Deletion; Staurosporine; Tissue Plasminogen Activator; Transcription Factors; Transfection; Tretinoin; Tumor Cells, Cultured | 1995 |
Membranes of human neuroblastoma SH-SY5Y cells contain specific binding sites for [3H]K-252A.
Topics: Alkaloids; Binding Sites; Carbazoles; Cell Line; Humans; Indole Alkaloids; Indoles; Kinetics; Maleimides; Neuroblastoma; Protein Kinase C; Staurosporine; Substrate Specificity; Tritium; Tumor Cells, Cultured | 1995 |
Effect of protein kinase C inhibitors on the antiviral activity of human alpha interferon in herpes simplex virus-infected human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Herpesvirus 1, Human; Humans; Interferon Type I; Interferon-alpha; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Recombinant Proteins; Staurosporine; Tumor Cells, Cultured | 1995 |
Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaloids; Aluminum Compounds; Animals; Brain; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fluorides; GTP-Binding Proteins; Humans; Isoenzymes; Isoproterenol; Kinetics; Manganese; Neuroblastoma; Neuropeptide Y; Propanolamines; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.
Topics: Alkaloids; Base Sequence; Cell Differentiation; Humans; Molecular Sequence Data; Neuroblastoma; Neuropeptide Y; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Alkaloids; Animals; Down-Regulation; Enzyme Activation; Humans; Inosine Triphosphate; Isoquinolines; Neuroblastoma; PC12 Cells; Phosphatidylinositols; Piperazines; Protein Kinase C; Second Messenger Systems; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The effect of polyamines on voltage-activated calcium channels in mouse neuroblastoma cells.
Topics: Alkaloids; Animals; Calcium Channels; Carbazoles; Electric Stimulation; Indoles; Membrane Potentials; Mice; Neuroblastoma; Polyamines; Protein Kinase C; Putrescine; Pyrroles; Staurosporine; Tumor Cells, Cultured | 1993 |
Local anaesthetics do not affect protein kinase C function in intact neuroblastoma cells.
Topics: Alkaloids; Anesthetics, Local; Animals; Cell Differentiation; Humans; Mice; Models, Biological; Neurites; Neuroblastoma; Phosphatidylinositols; Protein Kinase C; Receptors, Muscarinic; Staurosporine; Tumor Cells, Cultured | 1993 |
Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway.
Topics: Alkaloids; Bryostatins; Cell Differentiation; Cellular Senescence; Gene Expression; Genes, fos; Humans; Lactones; Macrolides; Neuroblastoma; Neurons; Phenotype; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Mas; Staurosporine; Subcellular Fractions; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Programmed cell death in neurotumour cells involves the generation of ceramide.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Apoptosis; Cell Survival; Ceramides; Diacylglycerol Kinase; DNA; Enzyme Inhibitors; Ganglia, Spinal; Hippocampus; Hybrid Cells; Mice; Neuroblastoma; Neurons; Neurons, Afferent; Palmitic Acid; Palmitic Acids; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rats; Signal Transduction; Sphingomyelins; Staurosporine | 1996 |
1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms.
Topics: 1-Methyl-4-phenylpyridinium; Anti-Bacterial Agents; Antimycin A; Blotting, Western; Cell Death; DNA Damage; Enzyme Inhibitors; Genes, bcl-2; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Oligomycins; Staurosporine; Tumor Cells, Cultured | 1995 |
Decrease in neuron-restrictive silencer factor (NRSF) mRNA levels during differentiation of cultured neuroblastoma cells.
Topics: Actins; Brain Neoplasms; Carcinogens; Cell Differentiation; Colforsin; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma; Pheochromocytoma; Polymerase Chain Reaction; Repressor Proteins; RNA, Messenger; Staurosporine; Transcription Factors; Tumor Cells, Cultured | 1996 |
Differential effect of tacrine and physostigmine on the secretion of the beta-amyloid precursor protein in cell lines.
Topics: Amyloid beta-Protein Precursor; Animals; Arecoline; Astrocytes; Atropine; Calcimycin; Carbachol; Cholinesterase Inhibitors; Enzyme Inhibitors; HeLa Cells; Humans; Ionophores; Muscarinic Agonists; Muscarinic Antagonists; Neuroblastoma; PC12 Cells; Physostigmine; Rats; Staurosporine; Tacrine | 1996 |
Long-term regulation of synapsin I gene expression and neuronal morphology by cyclic AMP and low-dose staurosporine.
Topics: Adenylyl Cyclases; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; DNA Primers; Dopamine beta-Hydroxylase; Humans; Kinetics; Neuroblastoma; Neurons; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Synapsins; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Sequence; Animals; Brain Neoplasms; Calcineurin; Calmodulin-Binding Proteins; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Glioma; Half-Life; Molecular Sequence Data; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Rats; Receptors, Serotonin; Staurosporine; Tumor Cells, Cultured | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Calpain; Caspase 1; Cell Line; Cells, Cultured; Cerebellum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Kinetics; Marine Toxins; Molecular Sequence Data; Neuroblastoma; Neurons; Oxocins; PC12 Cells; Rats; Spectrin; Staurosporine; Substrate Specificity; Tumor Cells, Cultured | 1996 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Cell Nucleus; Enzyme Inhibitors; Half-Life; Humans; Mutation; Neuroblastoma; Protein Kinase Inhibitors; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Localization of voltage-sensitive Ca2+ fluxes and neuropeptide Y immunoreactivity to varicosities in SH-SY5Y human neuroblastoma cells differentiated by treatment with the protein kinase inhibitor staurosporine.
Topics: Brain Neoplasms; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Culture Media; Electrophysiology; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Immunohistochemistry; Ion Channel Gating; Neuroblastoma; Neuropeptide Y; Protein Kinase Inhibitors; Staurosporine | 1997 |
Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells.
Topics: Antibody Specificity; Apoptosis; Aspartic Acid; Caspase 1; Caspase 3; Caspases; Coumarins; Cysteine Endopeptidases; DNA; Enzyme Inhibitors; Enzyme Precursors; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Hydrolysis; Neuroblastoma; Neurons; Oligopeptides; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Staurosporine; Tumor Cells, Cultured | 1997 |
Cholecystokinin-induced desensitization, receptor phosphorylation, and internalization in the CHP212 neuroblastoma cell line.
Topics: Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Fluorescent Dyes; GTP-Binding Proteins; Humans; Hypertonic Solutions; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Phosphorylation; Receptors, Cholecystokinin; Rhodamines; Sensitivity and Specificity; Sincalide; Staurosporine; Tumor Cells, Cultured | 1997 |
Chronic exposure to kappa-opioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that may involve ceramide.
Topics: Analgesics; Androstadienes; Animals; Apoptosis; Benzeneacetamides; Cell Line, Transformed; Cell Survival; Ceramides; Chromones; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression; Mice; Morpholines; Narcotics; Neuroblastoma; Neurons; Pyrrolidines; Receptors, Opioid, kappa; Staurosporine; Time Factors; Wortmannin | 1997 |
Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines.
Topics: Cell Death; DNA Fragmentation; DNA, Neoplasm; Humans; In Vitro Techniques; Microscopy, Electron; Neurites; Neuroblastoma; Osmolar Concentration; Staurosporine; Tumor Cells, Cultured | 1997 |
Staurosporine differentiated human SH-SY5Y neuroblastoma cultures exhibit transient apoptosis and trophic factor independence.
Topics: Apoptosis; Aurintricarboxylic Acid; Calcium Channels; Cell Differentiation; Cell Survival; Electrophysiology; Enzyme Inhibitors; Humans; Ion Channel Gating; Nerve Growth Factors; Neuroblastoma; Neurons; Norepinephrine; Phenotype; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1997 |
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Dinoprostone; Endocannabinoids; Enzyme Activation; Ethanolamines; Genistein; GTP-Binding Proteins; Linoleic Acids; Macrophages; Mice; Naphthalenes; Neuroblastoma; Nitriles; Palmitic Acids; Phospholipases A; Polyunsaturated Alkamides; Second Messenger Systems; Staurosporine; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella | 1997 |
Differentiation of cultured neuroblastoma induced by staurosporine and cyclic AMP: methods for assessing a neuronal phenotype.
Topics: Cell Differentiation; Cell Division; Cyclic AMP; Humans; Neuroblastoma; Neurology; Neurons; Phenotype; Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells.
Topics: Animals; bcl-2-Associated X Protein; Bucladesine; Cell Death; Dimerization; DNA Fragmentation; Gene Expression; Genes, p53; Humans; Immunohistochemistry; Mice; Neuroblastoma; Nitric Oxide; Oxidation-Reduction; Penicillamine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; S-Nitroso-N-Acetylpenicillamine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
GDNF-induced neurite formation was stimulated by protein kinase inhibitors and suppressed by Ras inhibitors.
Topics: Enzyme Inhibitors; Glial Cell Line-Derived Neurotrophic Factor; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neuroblastoma; Neuroprotective Agents; Polyenes; Polyunsaturated Alkamides; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Staurosporine; Tumor Cells, Cultured | 1997 |
Noninvasive monitoring of apoptosis versus necrosis in a neuroblastoma cell line expressing a nuclear pore protein tagged with the green fluorescent protein.
Topics: Apoptosis; Benzoquinones; Biomarkers; Chromatin; DNA Fragmentation; Green Fluorescent Proteins; Humans; Luminescent Proteins; Membrane Proteins; Necrosis; Neuroblastoma; Nuclear Envelope; Nuclear Proteins; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Cells, Cultured | 1998 |
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.
Topics: Animals; Cell Line; Cell Nucleus; Glutamine; Humans; Huntingtin Protein; Huntington Disease; Kidney; Mice; Nerve Tissue Proteins; Neuroblastoma; Nuclear Proteins; Peptide Fragments; Repetitive Sequences, Nucleic Acid; Staurosporine; Transfection; Tumor Cells, Cultured | 1998 |
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
Topics: Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspases; Cysteine Endopeptidases; DNA Fragmentation; Exons; Female; Humans; Mice; Mice, Knockout; Neuroblastoma; Polymerase Chain Reaction; Protein Biosynthesis; Recombinant Proteins; RNA Precursors; RNA Splicing; RNA, Messenger; Sequence Deletion; Staurosporine; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Caspase 3; Caspases; Chlorobenzoates; Cysteine Endopeptidases; Enzyme Inhibitors; Humans; Mice; Neuroblastoma; Peptide Fragments; Recombinant Proteins; Staurosporine; Thapsigargin; Tumor Cells, Cultured | 1998 |
Poly(ADP ribose) polymerase cleavage precedes neuronal death in the hippocampus and cerebellum following injury to the developing rat forebrain.
Topics: 3T3 Cells; Age Factors; Animals; Apoptosis; Blotting, Western; Brain Ischemia; Caspases; Cerebellum; DNA Fragmentation; Enzyme Inhibitors; Hippocampus; Mice; Necrosis; Needles; Neuroblastoma; Neurons; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Prosencephalon; Rats; Rats, Wistar; Sodium Azide; Staurosporine; Trypan Blue; Tumor Cells, Cultured; Wounds, Stab | 1999 |
Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells.
Topics: Apoptosis; Brain Neoplasms; Caspases; DNA Fragmentation; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrazones; Immunoblotting; Neuroblastoma; Nuclear Proteins; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Pyridones; Staurosporine; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Biological Transport; Caspases; Cerebellum; Cytochrome c Group; Cytosol; Enzyme Activation; Humans; Mitochondria; Neuroblastoma; Neurons; Permeability; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Time Factors; Tissue Distribution; Tumor Cells, Cultured | 1999 |
Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Inhibitors; Mice; Neuroblastoma; Phenotype; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1999 |
Differential effects of staurosporine and retinoic acid on the vulnerability of the SH-SY5Y neuroblastoma cells: involvement of bcl-2 and p53 proteins.
Topics: Benzylamines; Cell Differentiation; Cell Survival; Fluorouracil; Gamma Rays; Humans; Neuroblastoma; Neurotoxins; Oxidopamine; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Modulation of tau phosphorylation within its microtubule-binding domain by cellular thiols.
Topics: Animals; Arsenicals; Binding Sites; Cells, Cultured; Cerebral Cortex; Cytoskeleton; Enzyme Inhibitors; Humans; Microtubules; Neuroblastoma; Oxidants; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Sulfhydryl Compounds; tau Proteins; Tumor Cells, Cultured | 1999 |
Modulation of tau phosphorylation and intracellular localization by cellular stress.
Topics: Anisomycin; Binding Sites; Cell Compartmentation; Cytoskeleton; Enzyme Activation; Epitopes; Humans; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neuroblastoma; Osmotic Pressure; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Sorbitol; Staurosporine; tau Proteins; Tumor Cells, Cultured | 2000 |
Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 1; Caspase 3; Caspase 9; Caspases; Dose-Response Relationship, Drug; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Heat-Shock Response; Hot Temperature; Lithium; Neuroblastoma; Neurons; Neuroprotective Agents; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Staurosporine; Tranquilizing Agents; Tumor Cells, Cultured | 2000 |
Regulation of plasma membrane blebbing by the cytoskeleton.
Topics: Acrylamide; Actins; Animals; Calcium; Cell Membrane; Cytoskeleton; Lysophospholipids; Myosins; Neuroblastoma; Nocodazole; Rats; Staurosporine; Stress, Mechanical; Tumor Cells, Cultured | 1999 |
Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma.
Topics: Apoptosis; Biomarkers; Caspase 3; Caspases; Cell Survival; Chromatin; DNA Polymerase I; Enzyme Induction; Enzyme Inhibitors; Etoposide; Humans; Kinetics; L-Lactate Dehydrogenase; Neuroblastoma; Poly(ADP-ribose) Polymerases; Staurosporine; Tumor Cells, Cultured | 2000 |
Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis.
Topics: Amino Acid Motifs; Apoptosis; Calcium Channels; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate Receptors; Neuroblastoma; Oligopeptides; Poly(ADP-ribose) Polymerases; Receptors, Cytoplasmic and Nuclear; Staurosporine; Tumor Cells, Cultured | 2000 |
CREB is cleaved by caspases during neural cell apoptosis.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase 9; Caspase Inhibitors; Caspases; Cyclic AMP Response Element-Binding Protein; Cytochrome c Group; Enzyme Inhibitors; Humans; Neuroblastoma; Neurons; Oligopeptides; PC12 Cells; Rats; Signal Transduction; Staurosporine; Transcription Factors; Tumor Cells, Cultured | 2000 |
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Blotting, Western; Caspase 2; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Neuroblastoma; Neurons; Proteins; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2000 |
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.
Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin | 2001 |
Differential responses of human neuroblastoma and glioblastoma to apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Membrane; Cell Survival; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Glioblastoma; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2001 |
Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Indoles; Isoenzymes; Mice; Neurites; Neuroblastoma; Protein Kinase C; Rosales; Staurosporine; Xanthenes; Xanthones | 2001 |
Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126).
Topics: Binding Sites; Blotting, Northern; Blotting, Western; Caspase 8; Caspase 9; Caspases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Microscopy, Fluorescence; Neuroblastoma; Neurons; Oxygen; Peptide Fragments; Prions; Protein Binding; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Staurosporine; Time Factors; Tumor Cells, Cultured | 2001 |
Okadaic acid-sensitive activation of Maxi Cl(-) channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells.
Topics: Animals; Carcinogens; Chloride Channels; Chlorides; Cyclic AMP; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Ion Channel Gating; Mice; Neuroblastoma; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Selective Estrogen Receptor Modulators; Signal Transduction; Staurosporine; Stilbenes; Tamoxifen; Toremifene; Tumor Cells, Cultured | 2001 |
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Topics: Antibiotics, Antineoplastic; Apoptosis; Chromones; Daunorubicin; Enzyme Inhibitors; Etoposide; Humans; Infant; Morpholines; Nerve Degeneration; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Neurons; Nucleic Acid Synthesis Inhibitors; Sphingosine; Staurosporine; Thiolester Hydrolases; Transfection; Tumor Cells, Cultured | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.
Topics: Apoptosis; Brain Ischemia; Calcium; Calcium-Transporting ATPases; Cytosol; Dantrolene; Egtazic Acid; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Hydroquinones; Indoles; Muscle Relaxants, Central; Neuroblastoma; Neurons; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sesquiterpenes; Staurosporine; Thapsigargin; Tumor Cells, Cultured | 2002 |
The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Caspase Inhibitors; Cell Differentiation; Enzyme Inhibitors; Humans; Neurites; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 2002 |
Pre-processed caspase-9 contained in mitochondria participates in apoptosis.
Topics: Apoptosis; Caspase 9; Caspases; Cell Nucleus; Cytosol; Enzyme Inhibitors; HeLa Cells; Humans; Mitochondria; Neuroblastoma; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Tumor Cells, Cultured | 2002 |
A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aspartic Acid; Caspase Inhibitors; Caspases; Cytoplasm; Dose-Response Relationship, Drug; Enzyme Precursors; HeLa Cells; Humans; Kinetics; Neuroblastoma; Poly(ADP-ribose) Polymerases; Protease Inhibitors; Research Design; Staurosporine; Tumor Cells, Cultured | 2002 |
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
Topics: Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-X Protein; Caspase 9; Caspases; Chromosome Deletion; Chromosomes, Human, Pair 1; Cytochrome c Group; DNA Primers; Enzyme Inhibitors; Gene Amplification; Genes, myc; Humans; Immunoblotting; In Situ Hybridization, Fluorescence; Loss of Heterozygosity; Microsatellite Repeats; Neuroblastoma; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Transcription, Genetic; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Gas1 is induced during and participates in excitotoxic neuronal death.
Topics: Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Cell Cycle Proteins; Cell Death; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; GPI-Linked Proteins; Humans; Membrane Proteins; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; Proto-Oncogene Proteins c-bcl-2; Rats; Resting Phase, Cell Cycle; RNA, Antisense; RNA, Messenger; Staurosporine; Tumor Cells, Cultured | 2002 |
Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors.
Topics: Apoptosis; Caspase 3; Caspases; Enzyme Activation; Enzyme Inhibitors; Humans; Huntingtin Protein; Huntington Disease; Immunoblotting; Macromolecular Substances; Nerve Tissue Proteins; Neuroblastoma; Nuclear Proteins; Osmolar Concentration; Poly(ADP-ribose) Polymerases; Sorbitol; Staurosporine; Transgenes; Trinucleotide Repeat Expansion; Tumor Cells, Cultured | 2002 |
Activation of caspase-3 alone is insufficient for apoptotic morphological changes in human neuroblastoma cells.
Topics: Anti-Bacterial Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Survival; Doxycycline; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Neuroblastoma; Protein Structure, Tertiary; Recombinant Fusion Proteins; Staurosporine; Transfection; Tumor Cells, Cultured | 2002 |
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Brain; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Staurosporine; Synucleins; Tumor Cells, Cultured; Up-Regulation | 2002 |
Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner.
Topics: Amino Acid Substitution; Apoptosis; Caspase 3; Caspases; Enzyme Activation; Enzyme Inhibitors; Gene Expression; GTP-Binding Proteins; Heat-Shock Response; Humans; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinases; Neuroblastoma; Osmolar Concentration; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Protein Glutamine gamma Glutamyltransferase 2; Signal Transduction; Staurosporine; Transfection; Transglutaminases; Tumor Cells, Cultured | 2002 |
Disparity between ionic mediators of volume regulation and apoptosis in N1E 115 mouse neuroblastoma cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Apoptosis; Bumetanide; Cell Membrane; Cell Size; Central Nervous System; Chloride Channels; Enzyme Inhibitors; Furosemide; Ion Channels; Mice; Neuroblastoma; Neurodegenerative Diseases; Neurons; Niflumic Acid; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Staurosporine; Tumor Cells, Cultured | 2002 |
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcimycin; Cyclic AMP; Egtazic Acid; Isoquinolines; Mice; Neurites; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.
Topics: Alkaloids; Amino Acid Sequence; Animals; Calcium; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Genistein; Isoflavones; Kinetics; Mice; Molecular Sequence Data; Neurites; Neuroblastoma; Neurons; Oligopeptides; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Thrombin; Second Messenger Systems; Signal Transduction; Staurosporine; Thrombin; Vanadates | 1992 |
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Colforsin; Humans; Immunohistochemistry; Isoquinolines; Nervous System Neoplasms; Neurites; Neuroblastoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tumor Cells, Cultured | 1992 |
Retinoic acid- and staurosporine-induced bidirectional differentiation of human neuroblastoma cell lines.
Topics: Alkaloids; Cell Differentiation; Cell Line; Humans; Melanocytes; Microscopy, Electron; Monophenol Monooxygenase; Neurites; Neuroblastoma; Neurons; Protein Kinase C; Staurosporine; Tretinoin | 1992 |
Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors.
Topics: Alkaloids; Cell Differentiation; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Humans; Neuroblastoma; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
H7, a protein kinase C inhibitor, increases the glutathione content of neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Enzyme Activation; Glutathione; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1992 |
Bradykinin evoked depolarization of a novel neuroblastoma x DRG neurone hybrid cell line (ND7/23).
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cell Membrane; Cells, Cultured; Cytosol; Evoked Potentials; Ganglia, Spinal; Hybrid Cells; Inositol Phosphates; Ionomycin; Membrane Potentials; Neuroblastoma; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Staurosporine | 1991 |
Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover.
Topics: Alkaloids; Carbachol; Glycerophospholipids; Humans; Inositol Phosphates; Neuroblastoma; Phosphatidic Acids; Phospholipase D; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Staurosporine-induced morphological differentiation of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Axons; Cell Differentiation; Colchicine; Cycloheximide; Humans; Isoquinolines; Microtubules; Neuroblastoma; Neurons; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Sulfonamides; Tumor Cells, Cultured | 1991 |
Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines.
Topics: Alkaloids; Cell Differentiation; Cytosol; Edetic Acid; Fibroblasts; Humans; Neuroblastoma; Neurons; Protein Kinase C; Staurosporine; Tretinoin; Tumor Cells, Cultured | 1990 |