staurosporine has been researched along with Neoplasms in 102 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 9 (8.82) | 18.2507 |
2000's | 45 (44.12) | 29.6817 |
2010's | 38 (37.25) | 24.3611 |
2020's | 10 (9.80) | 2.80 |
Authors | Studies |
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Flajolet, M; Greengard, P; Meijer, L | 1 |
Arries, S; Bauch, JL; Bouska, JJ; Claibone, A; Dalton, C; De Jong, R; Giranda, VL; Gong, J; Jakob, CG; Johnson, EF; Klinghofer, V; Li, Q; Li, T; Liu, X; Luo, Y; Marsh, KC; Oltersdorf, T; Rosenberg, SH; Shi, Y; Stoll, VS; Zhu, GD | 1 |
Abrams, J; Des Jong, R; Dinges, J; Fisher, J; Giranda, VL; Gong, J; Jakob, CG; Johnson, EF; Klinghofer, V; Li, Q; Li, T; Liu, X; Luo, Y; Oltersdorf, T; Packard, G; Rosenberg, SH; Shi, Y; Song, X; Stoll, VS; Thomas, S; Woods, KW; Zhu, GD | 1 |
Beharry, ZM; Knaak, C; Kraft, AS; Ma, J; McInnes, C; Smith, CD; Wang, W; Xia, Z | 1 |
Chen, X; Chen, Y; Gao, C; Jiang, Y; Li, Y; Liu, H; Luan, X; Tan, C; Zhang, C | 1 |
Cole, D; Denny, R; Gopalsamy, A; Hall, JP; Hu, Y; Ipek, M; Lee, J; Lin, LL; Liu, J; Luong, M; Ni, Y; Telliez, JB | 1 |
Hayano, M; Shimada, K; Skouta, R; Stockwell, BR | 1 |
Jia, Y; Li, X; Wang, X; Wen, Q; Xu, F; Xu, W; Zhang, L; Zhang, Y | 1 |
Hoda, N; Maqbool, M; Mobashir, M | 1 |
Demicheli, C; Dittz, D; Frézard, F; Ishfaq, M; Islam, A; Marzano, IM; Paz Lopes, MT; Perreira-Maia, EC; Rodrigues, BL | 1 |
Cheng, FX; Liao, CZ; Liu, XH; Shi, JB; Tang, WJ; Wang, Y; Yuan, XL | 1 |
Cai, Z; He, R; Huang, W; Liu, S; Lv, X; Pan, J; Pan, X; Shao, Y; Sun, J; Xi, J; Zhang, J; Zhao, Y; Zhuang, R | 1 |
Han, J; Lan, Z; Li, W; Tu, Y; Wang, C; Xu, S; Zheng, P; Zhou, Y; Zhu, W | 1 |
Ghosh, U; Kharkar, PS; Khedkar, VM; Kulkarni, MR; Kulkarni-Almeida, A; Lad, NP; Mane, MS; Pandit, SS; Sharma, R; Srivastava, A | 1 |
Bharate, SB; Joshi, P; Vishwakarma, RA | 1 |
Chen, Y; Gao, L; Li, J; Lu, W; Shen, Q; Tong, L; Zhang, Q | 1 |
Choi, MJ; Hur, W; Kim, JS; Lee, SH; Oh, CH; Roh, EJ; Sim, T; Yoo, KH | 1 |
Bollinger, J; Budhraja, A; Craig, J; Lang, WH; Ling, T; Maier, J; Marsico, TD; Opferman, J; Potts, MB; Rivas, F | 1 |
Abdel-Aziz, HA; Abou-Seri, SM; Bonardi, A; Eldehna, WM; Elgazar, AA; Fahim, SH; Gratteri, P; Kryštof, V; Nocentini, A; Said, MA; Soliman, DH; Supuran, CT | 1 |
Davis, J; Gustafson, JL; Hecht, D; Marconi, GD; Michaels, H; Molina, B; Nefzi, A; Ortiz, MA; Piedrafita, FJ; Toenjes, S | 1 |
Daelemans, D; De Jonghe, S; Dehaen, W; Hu, H; Krasniqi, B; Li, Y; Luyten, W; Persoons, L; Wang, R | 1 |
Fan, L; Lei, F; Liu, Y; Sheng, K; Song, Y; Wu, L; Wu, S; Zhang, Y; Zhao, W | 1 |
Dudenkova, VV; Gavrina, AI; Kovaleva, TF; Lukyanov, KA; Mozherov, AM; Shcheslavskiy, VI; Shirmanova, MV; Snopova, LB; Zagaynova, EV; Zelenova, EE | 1 |
Angeli, A; El-Malah, A; Elbaramawi, SS; Ibrahim, TS; Mahmoud, Z; Moustafa, N; Supuran, CT; Taher, ES | 1 |
Ahmad, SB; Aldossari, RM; Ali, A; Rashid, S; Rehman, MU | 1 |
Li, P; Liu, X; Liu, Y; Qiu, Y; Yang, Y; Yin, Y | 1 |
He, Y | 1 |
Al Kafri, N; Hafizi, S | 1 |
Hashimoto, M; Ishigaki, Y; Iwabuchi, K; Kamdar, RP; Matsui, T; Matsumoto, Y; Sakasai, R; Sharma, MK; Sunatani, Y | 1 |
Asami, Y; Crump, A; Ōmura, S | 1 |
Ambudkar, SV; Hsiao, SH; Hsu, SC; Huang, YH; Lusvarghi, S; Wu, CP | 1 |
Doyle, A; Leanza, L; O'Reilly, P; Szabo, I; Szegezdi, E; Venturini, E; Zoratti, M | 1 |
Blunt, M; Craggs, P; Hardwick, P; Hobbs, CI; Rowland, P; Shillings, A; Singh, O; Skarzynski, T; Smith, KJ; Tanner, R; Wall, I; Witty, DR | 1 |
Antonopoulos, C; Dubyak, GR; El Sanadi, C; Kaiser, WJ; Mocarski, ES | 1 |
Boren, J; Brindle, KM; Mahajan, S; Patel, II; Reichelt, S; Schreiner, A; Steuwe, C; Ul-Hasan, M | 1 |
Hwang, ES; Na, YR; Seok, SH; Son, D | 1 |
Dolznig, H; Hengstschläger, M; Kramer, N; Scherzer, M; Schwanzer-Pfeiffer, D; Unger, C; Unterleuthner, D; Walzl, A | 1 |
Basrur, V; Chen, X; Chung, F; Elenitoba-Johnson, KS; Lim, MS; Pagano, M; Rangnekar, VM; Sahasrabuddhe, AA; Szankasi, P | 1 |
Trendowski, M | 1 |
Chen, WC; Li, SD; Roy, A; Tang, WL; Undzys, E | 1 |
Huang, RC; Kimura, K | 1 |
Altiok, S; Conway, AJ; Holton, AB; Kreahling, J; Landis, DA; Sinatra, FL | 1 |
Giordano, A; Lapenna, S | 1 |
Kuntz, K; O'Connell, MJ | 1 |
Ambrose, EC; Kornbluth, J | 1 |
Demidenko, E; Eastman, A; Hou, H; Khan, N; Lariviere, JP; Mupparaju, SP; Swartz, HM | 1 |
Conley, BA; Dancey, J; Doroshow, JH; Figg, WD; Gardner, ER; Gutierrez, ME; Kummar, S; Melillo, G; Murgo, AJ; Sausville, EA | 1 |
Brahimi-Horn, MC; Chiche, J; Gounon, P; Mazure, NM; Pouysségur, J; Rouleau, M | 1 |
Amstutz, RA; Hecker, RM; Niggli, FK; Schäfer, BW; Wachtel, M; Walter, D | 1 |
Bartek, J; Hasvold, G; Lukas, J; Petersen, L; Syljuåsen, RG | 1 |
Adkins, DR; Arquette, MA; Cai, SR; Chen, RC; Creekmore, AN; Dancey, J; Ellis, MJ; Fleshman, JW; Fracasso, PM; Goodner, SA; Guo, Z; Lin, L; Ma, CX; McLeod, HL; Naughton, MJ; Picus, J; Piwnica-Worms, H; Pluard, TJ; Rader, JS; Rudek, MA; Ryan, CE; Soares, EM; Tan, BR; Tao, Y; Williams, KJ; Wright, LP | 1 |
Mologni, L | 1 |
Adamski, J; Halama, A; Möller, G | 1 |
Gadet, R; Gillet, G; Gonzalo, P; Hesling, C; Lopez, J; Mikaelian, I; Popgeorgiev, N; Prudent, J; Rimokh, R | 1 |
Chen, Y; Deng, X; Fang, Z; Lin, J; Sheng, F; Wei, Y; Xia, B; Zhong, W; Zhou, C; Zhou, J | 1 |
Chi, HT; Kano, Y; Ly, BT; Sato, Y; Tojo, A; Watanabe, T | 1 |
Senderowicz, AM | 4 |
Swanton, C | 1 |
Campbell, A; Clark, JW; Deluca, P; Eder, JP; Garcia-Carbonero, R; LoRusso, P; Puchalski, TA; Rothermel, J; Ryan, DP; Supko, JG; Wozniak, A | 1 |
Lam, MH; Rosen, JM | 1 |
Cao, P; Gronda, M; Hedley, DW; Jacobberger, JW; Pham, NA; Schimmer, AD | 1 |
Altieri, DC; Beltrami, E; Dohi, T; Plescia, J; Wall, NR | 1 |
Acharya, MR; Chen, H; Figg, WD; Headlee, D; Kuwabara, T; Messmann, RA; Murgo, AJ; Sausville, EA; Senderowicz, AM; Sparreboom, A; Venzon, DJ | 1 |
Sausville, EA | 1 |
Gonen, M; Ilson, DI; Kaubisch, A; Kelsen, DP; Kemeny, N; Kortmansky, J; Maki, RG; O'reilly, E; Saltz, LB; Schwartz, GK; Shah, MA; Sowers, R; Tong, W; Weyerbacher, A; Yi, S | 1 |
Aylesworth, C; Baker, SD; Carducci, MA; Davidson, SB; Dees, EC; Donehower, RC; Elza-Brown, K; O'Reilly, S; Rudek, MA | 1 |
Blagden, S; de Bono, J | 1 |
Shi, HY; Zhang, M; Zhang, W | 1 |
Doroshow, JH; Frankel, P; Gandara, DR; Gumerlock, PH; Lara, PN; Longmate, J; Mack, PC; Synold, T | 1 |
Asanuma, H; Hata, F; Hirata, K; Hirohashi, Y; Kamiguchi, K; Kurotaki, T; Nabeta, C; Nakanishi, K; Ohmura, T; Sato, N; Sato, T; Torigoe, T; Tsuruma, T; Yamaguchi, K; Yamamoto, M | 1 |
Baras, A; Chua, A; Maxhimer, JB; Nguyen, DM; Schrump, DS; Shamimi-Noori, S; Yeow, WS; Ziauddin, MF | 1 |
Beaulieu, B; Beelen, AP; Eastman, A; Ernstoff, MS; Johnston, N; Lewis, LD; Olszanski, AJ; Perez, RP; Rhodes, CH | 1 |
Baker, SD; Carducci, MA; Dancey, J; Donehower, RC; Hidalgo, M; Jimeno, A; Laheru, DA; Messersmith, WA; Purcell, T; Rudek, MA | 1 |
Bauer, KS; Bisacia, S; Dancey, J; Edelman, MJ; Smith, R; Wu, S | 1 |
Brüne, B; Geisslinger, G; Johann, AM; Schmidt, H; Tzieply, N; von Knethen, A; Weigert, A | 1 |
Chen, XG; Zuo, MX | 1 |
Barnes, JM; Cohen, MB; Henry, MD; Rokhlin, OW; Svensson, RU | 1 |
Fassl, A; Gdynia, G; Lehmann-Koch, J; Matsuzawa, S; Reed, JC; Roth, W; Sieber, S; Tagscherer, KE; Zentgraf, H | 1 |
Azuma, T; Chen, L; Flies, AS; Flies, SJ; Yao, S; Zhu, G | 1 |
Eastman, A; Fanous, AA; Levesque, AA; Poh, A | 1 |
Hakomori, S | 1 |
Blume, E | 1 |
Broxterman, HJ; Eekman, CA; Kuiper, CM; Lankelma, J; Pinedo, HM; Schuurhuis, GJ; Versantvoort, CH | 1 |
Beltran, P; Fan, D; Fidler, IJ; Killion, JJ; O'Brian, CA; Wilson, MR; Yoon, SS | 1 |
Baldwin, AS; Mayo, MW; Wang, CY | 1 |
Lavelle, F | 1 |
Blomhoff, HK; Jonassen, TS; Skarstad, K; Smedshammer, L; Steen, HB; Stokke, T | 1 |
Amarante-Mendes, GP; Cotter, TG; Finucane, DM; Green, DR; Martin, SJ; Salvesen, GS | 1 |
Balkwill, F; Braybrook, J; Caponigro, F; Dobbs, N; Fabbro, D; Ganesan, T; Harris, A; Hutchison, C; Man, A; McDonald, A; Propper, D; Talbot, D; Thavasu, P; Twelves, C | 1 |
Sausville, EA; Senderowicz, AM | 1 |
Bodis, S; Campochiaro, P; Csermak, K; Fabbro, D; Man, A; Meyer, T; O'Reilly, T; Pruschy, M; Ruetz, S; Wood, J | 1 |
Darzynkiewicz, Z | 1 |
Bodis, S; Fabbro, D; Glanzmann, C; Lowe, SW; Pruschy, M; Rocha, S; Soengas, MS; Winterhalter, K | 1 |
Bodis, S; Fisher, DE; Glanzmann, C; Hess, C; Pruschy, M; Rocha, S; Tenzer, A; Zaugg, K | 1 |
Balkwill, F; Blackie, R; Braybrooke, JP; Caponigro, F; Dutreix, C; Ganesan, TS; Graf, P; Harris, AL; Kaye, SB; Man, A; McDonald, AC; Propper, DJ; Talbot, DC; Thavasu, P; Twelves, C | 1 |
Arbuck, SG; Bauer, KS; Figg, WD; Fuse, E; Headlee, D; Jaken, S; Jing , X; Kuwabara, T; Lahusen, T; Lush, RM; Messmann, R; Murgo, A; Roberge, M; Sausville, EA; Senderowicz, AM | 1 |
Engels, IH; Janssen, O; Kabelitz, D; Lauber, K; Schulze-Osthoff, K; Stepczynska, A; Wesselborg, S | 1 |
Carter, CA | 1 |
Borner, C; Gilb, B; Kaufmann, T; Kersten, A; Kirkin, V; Kiss, J; Schempp, CM; Simon, JC; Simon-Haarhaus, B; Sleeman, JP; Termeer, CC | 1 |
19 review(s) available for staurosporine and Neoplasms
Article | Year |
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Pharmacological inhibitors of glycogen synthase kinase 3.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Neoplasms; Nervous System Diseases; Parasitic Diseases; Signal Transduction; Stem Cells; Structure-Activity Relationship | 2004 |
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Diabetes Mellitus; Glycogen Synthase Kinase 3; Hippocampus; Humans; Hypoglycemic Agents; Inflammation; Molecular Targeted Therapy; Neoplasms; Protein Kinase Inhibitors | 2016 |
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2017 |
Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Fluorescent Dyes; Humans; Molecular Structure; Neoplasms; Tetralones | 2022 |
Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Carbazoles; Drug Discovery; Furans; Humans; Imatinib Mesylate; Neoplasms; Protein Kinase Inhibitors; Staurosporine | 2018 |
Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach.
Topics: Cytochalasins; Cytoskeleton; Depsipeptides; Humans; Indole Alkaloids; Neoplasms; Staurosporine | 2014 |
Cell cycle kinases as therapeutic targets for cancer.
Topics: Animals; Aurora Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinases; DNA Damage; Humans; Neoplasms; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Retinoblastoma-Like Protein p130; Staurosporine | 2009 |
The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?
Topics: Antineoplastic Agents; Biological Evolution; Cell Cycle Proteins; Checkpoint Kinase 1; Conserved Sequence; DNA Damage; DNA, Neoplasm; DNA, Single-Stranded; Drug Delivery Systems; G2 Phase; Genes, cdc; Humans; Neoplasm Proteins; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Replication Protein A; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Species Specificity; Staurosporine | 2009 |
Development of RET kinase inhibitors for targeted cancer therapy.
Topics: Antineoplastic Agents; Humans; Indoles; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-ret; Pyrimidines; Quinazolines; Staurosporine; Urea | 2011 |
The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2002 |
Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Clinical Trials, Phase I as Topic; Cyclin-Dependent Kinases; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Humans; Neoplasm Proteins; Neoplasms; Piperidines; Signal Transduction; Staurosporine; Transcription, Genetic | 2002 |
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine; Tumor Cells, Cultured | 2003 |
Cell-cycle targeted therapies.
Topics: Animals; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2004 |
Chk1 versus Cdc25: chking one's levels of cellular proliferation.
Topics: Animals; Antineoplastic Agents; cdc25 Phosphatases; Cell Cycle Proteins; Cell Proliferation; Checkpoint Kinase 1; Clinical Trials as Topic; Humans; Mice; Models, Biological; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine | 2004 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Piperidines; Protein Kinase Inhibitors; Staurosporine | 2005 |
[Research on cyclin-dependent kinase inhibitors: state of the art and perspective].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Cyclins; Flavonoids; Humans; Neoplasms; Piperidines; Purines; Roscovitine; Staurosporine | 2007 |
Preclinical and clinical development of cyclin-dependent kinase modulators.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; Clinical Trials as Topic; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flavonoids; Humans; Neoplasms; Piperidines; Staurosporine | 2000 |
Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Delivery Systems; Enzyme Inhibitors; Gastrointestinal Neoplasms; Humans; Isoenzymes; Lung Neoplasms; Neoplasm Proteins; Neoplasms; Oligonucleotides, Antisense; Protein Kinase C; Retinoids; Staurosporine; Tretinoin | 2000 |
14 trial(s) available for staurosporine and Neoplasms
Article | Year |
---|---|
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation.
Topics: Apoptosis; bcl-Associated Death Protein; Caspases; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Female; Gene Knockdown Techniques; Humans; Lymphokines; Macrophages; Male; Neoplasms; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Staurosporine | 2014 |
A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasms; Prednisone; Staurosporine; Young Adult | 2010 |
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Staurosporine; Young Adult | 2011 |
A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-fluorouracil in patients with advanced solid malignancies.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Drugs, Investigational; Female; Fluorouracil; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Staurosporine | 2004 |
Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine.
Topics: Antineoplastic Agents; Female; Half-Life; Humans; Infusions, Intravenous; Male; Neoplasms; Orosomucoid; Staurosporine | 2004 |
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Protein Kinase Inhibitors; Staurosporine; Treatment Outcome | 2005 |
A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Protein Kinase C; Salvage Therapy; Staurosporine; Time Factors | 2005 |
The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Atrial Fibrillation; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Cisplatin; Cyclin B; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Deglutition Disorders; Dose-Response Relationship, Drug; Female; Humans; Hyponatremia; Infections; Male; Middle Aged; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Renal Insufficiency; Staurosporine; Tachycardia; Treatment Outcome; Tumor Suppressor Proteins | 2005 |
Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850).
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Cell Cycle; Cisplatin; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Injections, Intravenous; Maximum Tolerated Dose; Neoplasms; Predictive Value of Tests; Staurosporine; Tissue Distribution; Treatment Outcome | 2006 |
Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Staurosporine; Topoisomerase I Inhibitors | 2008 |
Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Synergism; Female; Humans; Male; Middle Aged; Neoplasms; Staurosporine | 2007 |
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; Enzyme Inhibitors; Humans; Lymphocytes; Middle Aged; Mitogen-Activated Protein Kinase 1; Neoplasms; Protein Kinase C; Staurosporine | 1999 |
Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Neoplasms; Staurosporine | 2001 |
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents; DNA Damage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Hyperglycemia; Hypotension; Infusions, Intravenous; Lymphoma, Large B-Cell, Diffuse; Male; Melanoma; Middle Aged; Nausea; Neoplasms; Skin Neoplasms; Staurosporine; Vomiting | 2001 |
69 other study(ies) available for staurosporine and Neoplasms
Article | Year |
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Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Proliferation; Enzyme Inhibitors; Ethylenes; Glycogen Synthase Kinase 3; Humans; Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship | 2006 |
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Topics: Antineoplastic Agents; Cell Line; Hydrogen Bonding; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Structure-Activity Relationship; X-Ray Diffraction | 2006 |
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell-Free System; Combinatorial Chemistry Techniques; Female; Humans; Kinetics; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Structure-Activity Relationship; Thiazolidinediones | 2009 |
Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Proliferation; Drug Discovery; ErbB Receptors; Hep G2 Cells; Humans; Models, Molecular; Neoplasms; Protein Kinase Inhibitors; Receptors, Platelet-Derived Growth Factor; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2 | 2011 |
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Topics: Animals; Drug Discovery; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; MAP Kinase Kinase Kinases; Microsomes, Liver; Molecular Targeted Therapy; Monocytes; Neoplasms; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrimidines; Rats; Structure-Activity Relationship; Substrate Specificity | 2011 |
Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.
Topics: Antineoplastic Agents; Carbolines; Cell Death; Cell Line, Tumor; Cell Survival; Drug Design; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Neoplasms | 2012 |
Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: synthesis and biological evaluation. Part II.
Topics: Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Discovery; Human Umbilical Vein Endothelial Cells; Humans; Male; Models, Molecular; Molecular Structure; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides; Triazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Cytotoxicity and apoptotic activity of novel organobismuth(V) and organoantimony(V) complexes in different cancer cell lines.
Topics: Animals; Antimony; Antineoplastic Agents; Apoptosis; Bismuth; Cell Line; Cell Line, Tumor; Coordination Complexes; Crystallography, X-Ray; Humans; Mice; Models, Molecular; Neoplasms | 2016 |
Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Hep G2 Cells; Humans; Male; Mice; Molecular Docking Simulation; Neoplasms; Pyrazoles; Rats; Rats, Sprague-Dawley; Telomerase | 2016 |
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridines; Pyrimidines | 2017 |
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Semicarbazones; Structure-Activity Relationship | 2017 |
Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.
Topics: Antineoplastic Agents; Carbazoles; Drug Discovery; Extracellular Signal-Regulated MAP Kinases; Humans; Molecular Docking Simulation; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Retinoblastoma Protein; Structure-Activity Relationship | 2017 |
Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR.
Topics: Animals; Antineoplastic Agents; Aurora Kinase A; Aurora Kinase B; Azepines; Cell Line, Tumor; Humans; Mice; Mice, Nude; Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Vascular Endothelial Growth Factor Receptor-2 | 2018 |
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.
Topics: Amination; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoindoles; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrimidines; Receptor Protein-Tyrosine Kinases | 2018 |
Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Jatropha; Membrane Potential, Mitochondrial; Mitophagy; Neoplasms; Poly (ADP-Ribose) Polymerase-1; Reactive Oxygen Species | 2019 |
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
Topics: Antineoplastic Agents; Azo Compounds; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Molecular Docking Simulation; Molecular Structure; Neoplasms; Pyrazoles; Structure-Activity Relationship; Sulfonamides | 2020 |
Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase.
Topics: Antineoplastic Agents; Combinatorial Chemistry Techniques; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Molecular Structure; Neoplasms; Protein Serine-Threonine Kinases; Small Molecule Libraries; Sulfonamides | 2020 |
Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Proliferation; HL-60 Cells; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triterpenes | 2021 |
Insight into redox regulation of apoptosis in cancer cells with multiparametric live-cell microscopy.
Topics: Apoptosis; Caspase 3; Cisplatin; Microscopy, Fluorescence; NAD; NADP; Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; Staurosporine | 2022 |
Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Molecular Structure; Neoplasms; Protein Isoforms; Quinolines; Schiff Bases; Staurosporine; Structure-Activity Relationship; Sulfonamides | 2023 |
Computational Approaches for Identification of Potential Plant Bioactives as Novel G6PD Inhibitors Using Advanced Tools and Databases.
Topics: Glucosephosphate Dehydrogenase; Humans; Molecular Dynamics Simulation; Neoplasms; Pentose Phosphate Pathway; Staurosporine | 2023 |
Systematic profiling of staralog response to acquired drug resistant kinase gatekeeper mutations in targeted cancer therapy.
Topics: Antineoplastic Agents; Crystallography, X-Ray; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Molecular Targeted Therapy; Mutation; Neoplasms; Protein Conformation; Protein Kinase Inhibitors; Staurosporine | 2020 |
Systematic response of staurosporine scaffold-based inhibitors to drug-resistant cancer kinase mutations.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Mutation; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Structure-Activity Relationship | 2020 |
Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells.
Topics: Axl Receptor Tyrosine Kinase; Benzocycloheptenes; Blood Proteins; Cell Line, Tumor; Cell Movement; Cell Survival; Galectin 3; Galectins; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Neoplasms; Phosphorylation; Protein S; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Staurosporine; Triazoles | 2020 |
Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase.
Topics: Animals; Apoptosis; Cell Nucleus; Deoxyribonucleases; DNA Fragmentation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Mice; Neoplasms; Paclitaxel; Protein Serine-Threonine Kinases; Serine-Arginine Splicing Factors; Signal Transduction; Staurosporine; Vincristine | 2018 |
The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Repositioning; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Mice; Molecular Docking Simulation; Neoplasms; NIH 3T3 Cells; Protein Kinase Inhibitors; Staurosporine; Up-Regulation | 2019 |
Correlation between potassium channel expression and sensitivity to drug-induced cell death in tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cisplatin; Gene Expression Regulation, Neoplastic; Humans; Kv1.1 Potassium Channel; Kv1.3 Potassium Channel; Mitochondria; Neoplasms; Potassium Channel Blockers; RNA, Messenger; Sphingosine; Staurosporine; Tumor Burden | 2014 |
Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design.
Topics: Binding Sites; Cardiovascular Diseases; Crystallography, X-Ray; Drug Design; Humans; Ligands; MAP Kinase Kinase Kinase 5; Neoplasms; Neurodegenerative Diseases; Sf9 Cells; Signal Transduction; Staurosporine | 2013 |
Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Caspase 8; Caspase Inhibitors; Caspases; Caspases, Initiator; Cytoskeletal Proteins; Dendritic Cells; Doxorubicin; Inhibitor of Apoptosis Proteins; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; NLR Family, Pyrin Domain-Containing 3 Protein; Staurosporine; Toll-Like Receptor 4; Ubiquitin-Protein Ligases | 2013 |
CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.
Topics: Algorithms; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Screening Assays, Antitumor; Etoposide; Fluorescent Dyes; HCT116 Cells; Humans; Lipid Droplets; Lipids; Microscopy, Fluorescence; Neoplasms; Spectrum Analysis, Raman; Staurosporine | 2014 |
The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays.
Topics: Antineoplastic Agents; Apoptosis; Biological Assay; Cell Communication; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Edetic Acid; Egtazic Acid; HT29 Cells; Humans; Microscopy, Confocal; Neoplasms; Oxazines; Spheroids, Cellular; Staurosporine; Xanthenes | 2014 |
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Topics: Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; DEAD-box RNA Helicases; Enzyme Inhibitors; F-Box Proteins; HEK293 Cells; HeLa Cells; Humans; Molecular Sequence Data; Mutation; Neoplasms; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; RNA Interference; RNA, Small Interfering; Staurosporine; Ubiquitin-Protein Ligases; Ubiquitination | 2014 |
A Simple and Improved Active Loading Method to Efficiently Encapsulate Staurosporine into Lipid-Based Nanoparticles for Enhanced Therapy of Multidrug Resistant Cancer.
Topics: Animals; Cell Line, Tumor; Dimethyl Sulfoxide; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Lipids; Liposomes; Mice, Inbred BALB C; Models, Molecular; Nanoparticles; Neoplasms; Particle Size; Protein Kinase Inhibitors; Staurosporine | 2016 |
Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.
Topics: Antineoplastic Agents; Autophagy; Carbohydrate Metabolism; Caspase 7; Cell Line, Tumor; Down-Regulation; Drug Synergism; Energy Metabolism; Etoposide; Glutathione; Humans; Lipid Metabolism; Male; Masoprocol; Metabolic Networks and Pathways; Metabolome; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sirolimus; Staurosporine | 2016 |
Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Apoptosis; Biopsy; Cell Culture Techniques; Cell Proliferation; Doxorubicin; Enzyme Inhibitors; Female; Humans; Mice; Mice, Hairless; Mice, SCID; Microfluidic Analytical Techniques; Neoplasms; Staurosporine; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2017 |
Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cell Proliferation; Cytotoxicity, Immunologic; Down-Regulation; Etoposide; Gene Expression Regulation, Neoplastic; Gene Silencing; Green Fluorescent Proteins; Humans; K562 Cells; Killer Cells, Natural; Neoplasms; RNA, Messenger; RNA, Small Interfering; Staurosporine; Time Factors; Uridine Kinase | 2009 |
Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Electron Spin Resonance Spectroscopy; Female; Mice; Mice, Inbred C3H; Neoplasms; Oxygen; Staurosporine | 2009 |
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Hypoxia; Cell Proliferation; Drug Resistance, Neoplasm; Etoposide; GTP Phosphohydrolases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Membrane Proteins; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mitochondrial Swelling; Neoplasms; Phenotype; Proto-Oncogene Proteins; RNA Interference; Staurosporine; Time Factors; Transfection; Tumor Suppressor Proteins | 2010 |
p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Drug Synergism; Early Growth Response Protein 1; Female; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Genotype; Histone Deacetylase Inhibitors; Humans; Mice; Neoplasms; Paired Box Transcription Factors; Rhabdomyosarcoma, Alveolar; Staurosporine; Transcriptional Activation; Valproic Acid; Xenograft Model Antitumor Assays | 2010 |
p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.
Topics: Cell Cycle; Cell Death; Cell Survival; Checkpoint Kinase 1; Colonic Neoplasms; Genes, p53; HCT116 Cells; Humans; Neoplasms; Nervous System Neoplasms; Protein Kinases; Radiation, Ionizing; Staurosporine; Tumor Suppressor Protein p53 | 2010 |
Metabolic signatures in apoptotic human cancer cell lines.
Topics: Apoptosis; Biomarkers; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Enzyme Activation; HEK293 Cells; Hep G2 Cells; Humans; Metabolome; Metabolomics; Neoplasms; Staurosporine | 2011 |
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Membrane Proteins; Mice; Mitochondrial Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms; NIH 3T3 Cells; Oncogene Protein p21(ras); Proteolysis; raf Kinases; src-Family Kinases; Staurosporine; Thapsigargin | 2012 |
Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells.
Topics: Animals; Autophagy; Cisplatin; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Fluorescence; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Lysosomes; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; Neoplasms; Recombinant Fusion Proteins; Red Fluorescent Protein; Sirolimus; Staurosporine | 2012 |
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Hematopoiesis; Humans; Mitogen-Activated Protein Kinase Kinases; Neoplasms; Oncogene Proteins, Fusion; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; STAT5 Transcription Factor; Staurosporine | 2012 |
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Topics: Animals; Anticarcinogenic Agents; Antigens; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Glutathione; Humans; Isothiocyanates; Male; Membrane Potentials; Mice; Mice, SCID; Microscopy, Fluorescence; Mitochondria; Mitosis; Neoplasm Transplantation; Neoplasms; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Staurosporine; Sulfoxides; Thiocyanates; Time Factors; Tyrosine | 2004 |
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
Topics: Animals; Apoptosis; Caspases; Cell Hypoxia; Cell Line, Tumor; Endopeptidase K; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Mitochondria; Neoplasm Proteins; Neoplasms; Recombinant Fusion Proteins; Staurosporine; Subcellular Fractions; Survivin | 2004 |
Indifferently pursued or unowned drugs: who should lead where companies do not tread?
Topics: Antineoplastic Agents; Drug Industry; Humans; Neoplasms; Orphan Drug Production; Protein Kinase Inhibitors; Staurosporine | 2005 |
Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line; Cell Line, Tumor; Culture Media, Serum-Free; Cytochromes c; Cytosol; Disease Progression; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Mice; Microscopy, Fluorescence; Models, Statistical; Neoplasms; Proto-Oncogene Proteins c-bcl-2; Ribonucleases; Serpins; Staurosporine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2005 |
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Apoptosis; CARD Signaling Adaptor Proteins; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; fas Receptor; Fas-Associated Death Domain Protein; Humans; Jurkat Cells; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Protein Isoforms; Protein Structure, Tertiary; RNA, Messenger; RNA, Small Interfering; Staurosporine; Transfection | 2005 |
Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01.
Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Neoplasms; NF-kappa B; Staurosporine; Tumor Cells, Cultured; Valproic Acid | 2006 |
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Line, Tumor; Cell Polarity; Cell Survival; Coculture Techniques; Cytokines; Humans; Lysophospholipids; Macrophage Activation; Macrophages; Neoplasms; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Staurosporine | 2007 |
Chemotherapeutic agents up-regulate the cytomegalovirus promoter: implications for bioluminescence imaging of tumor response to therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cytomegalovirus; Doxorubicin; Humans; Luminescence; Male; Mice; Neoplasms; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Biosynthesis; Staurosporine; Up-Regulation | 2007 |
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Animals; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cytochromes c; Female; Glioblastoma; HeLa Cells; Humans; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mitochondria; Molecular Sequence Data; Neoplasms; Protein Binding; Proteins; Sequence Alignment; Staurosporine; Tissue Distribution; TNF-Related Apoptosis-Inducing Ligand | 2008 |
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Topics: Animals; Antigens, Surface; Apoptosis; Apoptosis Regulatory Proteins; B7-1 Antigen; B7-H1 Antigen; Cell Line, Tumor; Enzyme Inhibitors; fas Receptor; Humans; Immunity, Cellular; Membrane Glycoproteins; Mice; Mice, Inbred DBA; Neoplasms; Peptides; Programmed Cell Death 1 Receptor; Signal Transduction; Staurosporine; T-Lymphocytes | 2008 |
Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
Topics: Camptothecin; Cell Cycle; Cell Proliferation; Checkpoint Kinase 1; Cyclin B; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; G2 Phase; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Irinotecan; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; S Phase; Signal Transduction; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2008 |
Novel endothelial cell activation factor(s) released from activated platelets which induce E-selectin expression and tumor cell adhesion to endothelial cells: a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Factors; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cells, Cultured; Colonic Neoplasms; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Kinetics; Lung Neoplasms; Melanoma, Experimental; Mice; Models, Biological; Naphthalenes; Neoplasms; Piperazines; Platelet Activation; Platelet Aggregation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Stomach Neoplasms; Tumor Cells, Cultured; Umbilical Veins | 1994 |
Researchers gain footholds in the cell cycle.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Humans; Neoplasms; Pentoxifylline; Staurosporine | 1995 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Fluorouracil; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Protein Kinases; Staurosporine; Tumor Cells, Cultured | 1995 |
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Nucleus; Cycloheximide; Daunorubicin; DNA-Binding Proteins; Humans; I-kappa B Proteins; Interleukin-1; Leupeptins; Neoplasms; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Synthesis Inhibitors; Radiation, Ionizing; Staurosporine; Transcription Factor RelA; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
[Tyrosine protein kinase inhibitors in cancerology: the end of the beginning?].
Topics: Animals; ErbB Receptors; Humans; In Vitro Techniques; Male; Mice; Neoplasms; Prostatic Neoplasms; Protein-Tyrosine Kinases; Quinazolines; Rats; Staurosporine; Structure-Activity Relationship | 1997 |
Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases.
Topics: Cell Cycle; Cell Division; Cell Nucleus; Cells, Cultured; DNA; Fibroblasts; Genes, p53; Humans; Meiosis; Mitosis; Models, Biological; Neoplasms; Polyploidy; Protein Kinases; Retinoblastoma; Retinoblastoma Protein; S Phase; Staurosporine; Tumor Cells, Cultured | 1997 |
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Etoposide; fas Receptor; HL-60 Cells; Humans; Jurkat Cells; Neoplasms; Oncogenes; Staurosporine | 1998 |
PKC412--a protein kinase inhibitor with a broad therapeutic potential.
Topics: Angiogenesis Inhibitors; Animals; Blood Proteins; Cell Cycle; Clinical Trials, Phase I as Topic; Enzyme Inhibitors; Humans; Mice; Neoplasms; Protein Binding; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 2000 |
Re: preclinical and clinical development of cyclin-dependent kinase modulators.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cyclin-Dependent Kinases; Drug Design; Enzyme Inhibitors; Humans; Neoplasms; Signal Transduction; Staurosporine | 2000 |
Protein kinase C inhibitor and irradiation-induced apoptosis: relevance of the cytochrome c-mediated caspase-9 death pathway.
Topics: Animals; Apoptosis; Caspase 9; Caspases; Cytochrome c Group; Enzyme Inhibitors; Humans; Neoplasms; Protein Kinase C; Radiation Tolerance; Staurosporine; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Key targets for the execution of radiation-induced tumor cell apoptosis: the role of p53 and caspases.
Topics: Adenoviridae; Animals; Apoptosis; Caspases; Cell Cycle; DNA Repair; Enzyme Activation; Enzyme Inhibitors; Genes, p53; Genetic Therapy; Genetic Vectors; Humans; Mice; Mice, Knockout; Neoplasm Proteins; Neoplasms; Staurosporine | 2001 |
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Enzyme Activation; Etoposide; fas Receptor; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Mitochondria; Mitomycin; Neoplasms; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2001 |
Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Caspases; Cell Division; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Hypericum; Intracellular Membranes; Microscopy, Electron; Mitochondria; Neoplasms; Phloroglucinol; Rats; Staurosporine; Terpenes; Time Factors; Tumor Cells, Cultured | 2002 |