staurosporine has been researched along with Melanoma in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hah, JM; Kim, H; Kim, M; Lee, J; Yu, H | 1 |
| Chen, K; Li, B; Shen, J; Wang, G; Wang, H; Xu, Z; Yang, M; Zeng, B; Zhu, W | 1 |
| Abbe, P; Benhida, R; Cavazza, E; Cerezo, M; Jaune, E; Millet, A; Plaisant, M; Rocchi, S; Ronco, C | 1 |
| Bennett, KL; Borgdorff, V; Breitwieser, FP; Colinge, J; Gridling, M; Müller, AC; Rix, U; Superti-Furga, G; Wagner, C; Wagner, SN; Winter, GE | 1 |
| Cabezas-Herrera, J; Fernández-Pérez, MP; Montenegro, MF; Piñero-Madrona, A; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-del-Campo, L | 1 |
| Baczynska, D; Brézillon, S; Malicka-Blaszkiewicz, M; Maquart, FX; Nowak, D; Popow, A; Radwanska, A; Wegrowski, Y | 1 |
| Bentke, A; Laidler, P; Małecki, JM; Ostrowska, B | 1 |
| Agarwala, SS; Christensen, SD; Frankel, PH; Gandara, DR; Lara, PN; Li, T; Luu, T; Mack, PC; Margolin, KA | 1 |
| Fox, TE; Gowda, R; Hengst, J; Madhunapantula, SV; Robertson, GP; Yun, JK | 1 |
| Gillespie, SK; Hersey, P; Zhang, XD | 1 |
| An, WW; Ikejima, T; Onodera, S; Tashiro, S; Wang, MW | 1 |
| Ikejima, T; Onodera, S; Tashiro, S; Wang, C; Wang, MW | 2 |
| Grabacka, M; Plonka, PM; Reiss, K; Urbanska, K | 1 |
| Bowtell, D; Cohen, PS; Copeman, M; Gore, M; House, C; Lynch, K; Millward, MJ; Olver, IN; Wang, Y; Webster, L; Yap, A; Zalcberg, J | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Loitsch, S; Müller, J; Thaçi, D | 1 |
| Benassi, B; Biroccio, A; Zupi, G | 1 |
| Ballotti, R; Bertolotto, C; Bille, K; Giuliano, S; Hilmi, C; Larribere, L; Ortonne, JP | 1 |
| Banfi, P; Gambetta, RA; Mapelli, E; Sala, E; Sensi, M; Supino, R; Zunino, F | 1 |
| Goretzki, L; Mueller, BM | 1 |
| Cunningham, CC; da Silva, S; Mortara, RA; Procópio, DO | 1 |
| Ariza, ME; Broome-Powell, M; Kidd, VJ; Lahti, JM; Nelson, MA | 1 |
| Dong, H; Hirpara, JL; Kini, RM; Loh, KW; Pervaiz, S; Seyed, MA | 1 |
| Arbuck, SG; Bauer, KS; Figg, WD; Fuse, E; Headlee, D; Jaken, S; Jing , X; Kuwabara, T; Lahusen, T; Lush, RM; Messmann, R; Murgo, A; Roberge, M; Sausville, EA; Senderowicz, AM | 1 |
| Archer, RA; Howbert, JJ; Schultz, RM | 1 |
3 trial(s) available for staurosporine and Melanoma
| Article | Year |
|---|---|
A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; California; Cell Cycle; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Melanoma; Middle Aged; Protein Kinase C; Protein Kinase Inhibitors; Skin Neoplasms; Staurosporine; Time Factors; Treatment Outcome | 2012 |
The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study.
Topics: Adult; Aged; Antineoplastic Agents; Blotting, Western; Chromatography, High Pressure Liquid; Female; Humans; Isoenzymes; Male; Melanoma; Middle Aged; Protein Kinase C; Staurosporine; Survival Analysis; Treatment Outcome | 2006 |
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents; DNA Damage; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Hyperglycemia; Hypotension; Infusions, Intravenous; Lymphoma, Large B-Cell, Diffuse; Male; Melanoma; Middle Aged; Nausea; Neoplasms; Skin Neoplasms; Staurosporine; Vomiting | 2001 |
22 other study(ies) available for staurosporine and Melanoma
| Article | Year |
|---|---|
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Topics: Amides; Azepines; Cell Growth Processes; Cell Line, Tumor; Humans; Melanoma; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pyrazoles; Structure-Activity Relationship; U937 Cells | 2011 |
Overman rearrangement and Pomeranz-Fritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents.
Topics: Antineoplastic Agents; Benzazepines; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; HCT116 Cells; Hep G2 Cells; Humans; Indoles; K562 Cells; Melanoma; Molecular Structure; Niacinamide; Phenylurea Compounds; Quinolones; Sorafenib; Structure-Activity Relationship; Sulfonamides; Vemurafenib | 2013 |
Discovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells.
Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Mice; Pancreatic Neoplasms; Structure-Activity Relationship; Thiazoles | 2016 |
A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF.
Topics: AMP-Activated Protein Kinases; Blotting, Western; Cell Line; Cell Survival; Chromatography, Liquid; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Indoles; Mass Spectrometry; Melanocytes; Melanoma; Microphthalmia-Associated Transcription Factor; Oncogenes; Pyrroles; RNA Interference; RNA, Small Interfering; Staurosporine; Sunitinib; Transfection | 2014 |
Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Activation; Female; Gene Silencing; Humans; Melanoma; Methotrexate; Methylation; Mice; Myosin Heavy Chains; Myosin Type V; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Xenograft Model Antitumor Assays | 2013 |
Lumican affects actin cytoskeletal organization in human melanoma A375 cells.
Topics: Actins; Apoptosis; Blotting, Western; Cell Survival; Chondroitin Sulfate Proteoglycans; Collagen; Cytoskeleton; Cytosol; Fibronectins; Humans; Isomerism; Keratan Sulfate; Lumican; Melanoma; Microscopy, Confocal; Microscopy, Fluorescence; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Tetrazolium Salts; Thiazoles | 2008 |
Cytochalasin D, LY294002 and olomoucine synergize in promoting death of melanoma cells through activation of caspase-3 and apoptosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Chromones; Cytochalasin D; Drug Synergism; Enzyme Activation; Humans; In Situ Nick-End Labeling; Kinetin; Melanoma; Morpholines; Skin Neoplasms; Staurosporine; Up-Regulation | 2010 |
Targeting sphingosine kinase-1 to inhibit melanoma.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Humans; Lysophospholipids; Melanocytes; Melanoma; Mice; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Sphingosine; Staurosporine; Thiazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways.
Topics: Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carrier Proteins; Caspases; Cell Line, Tumor; Cytochromes c; Cytosol; Enzyme Activation; Flavoproteins; Humans; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Potentials; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Protein Conformation; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Staurosporine; Time Factors | 2004 |
Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C.
Topics: Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; DNA Fragmentation; Enzyme Activation; Humans; Melanoma; Mitogen-Activated Protein Kinases; Protein Kinase C; Staurosporine | 2005 |
Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
Topics: Androstadienes; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Evodia; Gene Expression; Genes, p53; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; MAP Kinase Signaling System; Melanoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Sirtuin 1; Sirtuins; Staurosporine; Wortmannin | 2005 |
[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].
Topics: Apoptosis; Cell Line, Tumor; Evodia; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Plant Extracts; Plants, Medicinal; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Staurosporine | 2005 |
Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt.
Topics: Animals; Cell Movement; Cell Proliferation; Down-Regulation; Enzyme Inhibitors; Fenofibrate; Humans; Hypolipidemic Agents; Melanoma; Mice; Neoplasm Metastasis; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured | 2006 |
Restoration of E-cadherin sensitizes human melanoma cells for apoptosis.
Topics: Apoptosis; Cadherins; Caspase 3; Caspase 8; Catenins; Cell Adhesion; Cell Line, Tumor; Cytochromes c; Cytosol; DNA Fragmentation; Humans; Melanoma; Neoplasm Metastasis; Protein Structure, Tertiary; Staurosporine | 2006 |
Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cisplatin; Fluorouracil; Glutamate-Cysteine Ligase; Glutathione; Humans; Melanoma; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Staurosporine | 2007 |
IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin.
Topics: Apoptosis; bcl-X Protein; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Insulin-Like Growth Factor I; Melanoma; Microtubule-Associated Proteins; Models, Biological; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Survivin; TNF-Related Apoptosis-Inducing Ligand | 2008 |
Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes.
Topics: Alkaloids; Cell Movement; Diglycerides; Humans; Isoenzymes; Melanoma; Neoplasm Invasiveness; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase.
Topics: Adenoviruses, Human; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Humans; Indole Alkaloids; Indoles; Isoflavones; Isoquinolines; Lactoferrin; Low Density Lipoprotein Receptor-Related Protein-1; Maleimides; Melanoma; Naphthalenes; Phenols; Protein Kinase C; Receptors, Immunologic; Signal Transduction; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1997 |
Trypanosoma cruzi: effect of protein kinase inhibitors and cytoskeletal protein organization and expression on host cell invasion by amastigotes and metacyclic trypomastigotes.
Topics: Actin Cytoskeleton; Animals; Chlorocebus aethiops; Cytoskeletal Proteins; Enzyme Inhibitors; Gelsolin; Genistein; HeLa Cells; Humans; Melanoma; Microfilament Proteins; Microtubules; Protein Kinase Inhibitors; Staurosporine; Trypanosoma cruzi; Tumor Cells, Cultured; Vero Cells | 1998 |
Fas-induced apoptosis in human malignant melanoma cell lines is associated with the activation of the p34(cdc2)-related PITSLRE protein kinases.
Topics: Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; CDC2 Protein Kinase; Cell Nucleus; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Enzyme Activation; Fas Ligand Protein; fas Receptor; Humans; Melanoma; Membrane Glycoproteins; Microinjections; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Staurosporine; Tumor Cells, Cultured | 1999 |
Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Transport; Caspase Inhibitors; Caspases; Cyclosporine; Cytochrome c Group; Cytosol; Enzyme Activation; Enzyme Inhibitors; Etoposide; Fluorescence; HL-60 Cells; Humans; Intracellular Membranes; Melanoma; Mitochondria; Mitochondria, Liver; Neoplasm Proteins; Oligopeptides; Permeability; Photochemistry; Pyrimidinones; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Signal Transduction; Skin Neoplasms; Staurosporine; Tumor Cells, Cultured | 2000 |
Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.
Topics: Adrenal Cortex Hormones; Alkaloids; Humans; Interleukin-1; Melanoma; Staurosporine; Tilorone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1989 |