staurosporine has been researched along with Leukemia in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.13) | 18.7374 |
| 1990's | 17 (36.17) | 18.2507 |
| 2000's | 18 (38.30) | 29.6817 |
| 2010's | 7 (14.89) | 24.3611 |
| 2020's | 4 (8.51) | 2.80 |
| Authors | Studies |
|---|---|
| Bassett, R; Budhraja, A; Das, S; Ling, T; Maier, J; Opferman, JT; Potts, MB; Rankovic, Z; Rivas, F; Shelat, A | 1 |
| Abe, N; Ino, M; Matsuo, N; Onose, JI; Sugaya, K | 1 |
| Andrews, C; Lam, W; Sibai, H | 1 |
| Cerchione, C; Martinelli, G | 1 |
| Abuín Blanco, A; Alonso Vence, N; Antelo Rodríguez, B; Bao Pérez, L; Bello López, JL; Bendaña López, Á; Cerchione, C; Cid López, M; Díaz Arias, JÁ; Ferreiro Ferro, R; González Pérez, MS; Martinelli, G; Melero Valentín, P; Montesinos Fernández, P; Mosquera Orgueira, A; Peleteiro Raíndo, A; Pérez Encinas, MM | 1 |
| Baer, MR; Bauer, KS; Carroll, M; Fleckinger, S; Gojo, I; Luger, S; Norsworthy, KJ; Perl, A; Sausville, EA; Tidwell, M | 1 |
| Berdel, WE; Blum, H; Bohlander, SK; Braess, J; Büchner, T; Dufour, A; Graf, A; Greif, PA; Herold, T; Hiddemann, W; Hopfner, KP; Kakadia, PM; Konstandin, NP; Krebs, S; Ksienzyk, B; Opatz, S; Polzer, H; Sauerland, MC; Schneider, S; Spiekermann, K; Vosberg, S; Woermann, BJ; Zellmeier, E | 1 |
| Ekberg, J; Persson, JL | 1 |
| Chao, DK; Chen, YJ; Clifford Chao, KS; Huang, YC | 1 |
| Kiyoi, H | 4 |
| Barrett, R; Christie, AL; Daley, JF; Frank, D; Galinsky, I; Griffin, JD; Kung, AL; Lazo-Kallanian, S; Nelson, E; Porter, D; Ray, A; Stone, R; Straub, C; Weisberg, E; Zawel, L | 1 |
| Fiedler, W; Wellbrock, J | 1 |
| Alemu, L; Anderson, S; Brinster, L; Gilliland, DG; Hoogstraten-Miller, S; Kamikubo, Y; Kench, M; Kirby, M; Liu, PP; Melenhorst, JJ; Zhao, L | 1 |
| Dent, P; Grant, S; Jia, W; Krystal, G; Rahmani, M; Sausville, EA; Yu, C | 1 |
| Boulton, C; Gilliland, DG; Griffin, JD; Gu, TL; Mohi, MG; Neel, BG; Neuberg, D; Sternberg, DW | 1 |
| Dent, P; Grant, S; Hahn, M; Li, W; Rahmani, M; Yu, C | 1 |
| Zhang, GS | 1 |
| Amaral, SM; Anastasiadou, E; Boulton, CL; Curley, DP; Duclos, N; Fabbro, D; Gilliland, DG; Griffin, JD; Huntly, BJ; Joseph, SW; Lee, BH; Williams, IR | 1 |
| Brown, P; Cohen, P; Deangelo, D; Estey, E; Galinsky, I; Giles, F; Kantarjian, H; Karp, JE; Levis, M; Pham, R; Roesel, J; Small, D; Smith, BD; Stine, A; Stone, R; Wang, Y | 1 |
| Chen, S; Dai, Y; Dent, P; Grant, S; Khanna, P; Pei, XY | 1 |
| Akutsu, M; Furukawa, Y; Izumi, T; Kano, Y; Kirito, K; Mano, H; Matsuo, Y; Odgerel, T; Sato, Y; Tsunoda, S; Vu, HA | 1 |
| Catley, L; Cools, J; Gilliland, G; Griffin, JD; Hall-Meyers, E; Jiang, J; Kung, AL; McMillin, DW; Mitsiades, C; Moreno, D; Ray, A; Tran, M; Weisberg, E; Wright, RD; Zawel, L | 1 |
| Lee, CW | 1 |
| Carlson, BA; Clark, JL; Sausville, EA; Wang, Q; Worland, PJ | 1 |
| Chorváth, B; Hunáková, L; Klobusická, M; Sedlák, J; Sulíková, M | 1 |
| Allen, PD; Dronfield, DM; Jia, L; Jiang, XR; Kelsey, SM; Newland, AC; Wu, YL | 1 |
| Bertrand, R; Dubrez, L; Eymin, B; Pommier, Y; Solary, E | 1 |
| Balasubramanyam, M; Gardner, JP | 1 |
| Aiuchi, T; Masuda, Y; Nakajo, S; Nakaya, K; Ohizumi, H; Watabe, M; Yoda, M | 1 |
| Anderson, H; Darzynkiewicz, Z; James, WM; Juan, G; Ray, JM; Roberge, M; Sauve, DM; Traganos, F | 1 |
| Chanock, SJ; Hiraoka, W; Nieves-Neira, W; Pommier, Y; Vazquez, N | 1 |
| Drexler, HG; Meyer, C; Steube, KG | 1 |
| Boise, LH; Dent, P; Grant, S; Tang, L | 1 |
| Dai, Y; Decker, R; Dent, P; Grant, S; Harvey, S; Kramer, L; Schaefer, G; Tang, L | 1 |
| Dai, Y; Dent, P; Grant, S; McInistry, R; Singh, V; Tang, L; Wang, Z; Yu, C | 1 |
| Brass, LF | 1 |
| Murgo, AJ; Sistare, FD | 1 |
| Altschuler, E; Chan, D; Hinds, M; Mayes, J; Zwelling, LA | 1 |
| Ardelt, B; Bruno, S; Darzynkiewicz, Z; Skierski, JS; Traganos, F | 1 |
| Konno, S; Wu, JM | 1 |
| Abraham, RT; Karnitz, L; Secrist, JP | 1 |
| Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S | 1 |
| Scholz, W | 1 |
| Ali, H; Beaven, MA; Cunha-Melo, JR; Gonzaga, HM; Huang, FL; Huang, KP | 1 |
4 review(s) available for staurosporine and Leukemia
| Article | Year |
|---|---|
[FLT3 kinase inhibitors for the treatment of acute leukemia].
Topics: Acute Disease; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Indazoles; Leukemia; Mutation; Piperazines; Quinazolines; Signal Transduction; Staurosporine | 2010 |
Clinical experience with antiangiogenic therapy in leukemia.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Benzenesulfonates; Bevacizumab; Clinical Trials as Topic; Humans; Indoles; Lenalidomide; Leukemia; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib; Thalidomide; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A | 2011 |
[Possibility of targeting FLT3 kinase for the treatment of leukemia].
Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib | 2005 |
[Novel molecularly target therapies for leukemia].
Topics: Antineoplastic Agents; Carbazoles; Farnesyltranstransferase; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia; Piperazines; Quinazolines; Staurosporine | 2007 |
2 trial(s) available for staurosporine and Leukemia
| Article | Year |
|---|---|
Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Leukemia; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Staurosporine; Treatment Outcome; Young Adult | 2013 |
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Topics: Adolescent; Adult; Amino Acid Substitution; Apoptosis; Base Sequence; Benzothiazoles; Cell Proliferation; Cell Transformation, Neoplastic; Core Binding Factor beta Subunit; Cytokines; DNA Mutational Analysis; Exome; Female; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Gene Rearrangement; Humans; Leukemia; Male; Middle Aged; Models, Molecular; Molecular Sequence Data; Mutation; Oncogene Proteins, Fusion; Phenylurea Compounds; Protein Kinase Inhibitors; Staurosporine | 2013 |
41 other study(ies) available for staurosporine and Leukemia
| Article | Year |
|---|---|
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Induction; Heterocyclic Compounds; Humans; Leukemia; Mice; Small Molecule Libraries; Therapeutic Index | 2019 |
Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells.
Topics: Animals; Basidiomycota; Cell Line, Tumor; Inhibitory Concentration 50; Leukemia; Mast Cells; Protein Kinase C beta; Rats; Staurosporine; Tumor Necrosis Factor-alpha | 2020 |
The successful use of
Topics: fms-Like Tyrosine Kinase 3; Humans; Leukemia; Leukemia, Myeloid, Acute; Phenotype; Protein Kinase Inhibitors; Staurosporine | 2020 |
Acute leukemias in 2020: state of the art.
Topics: Acute Disease; Aminopyridines; Antineoplastic Agents; Antineoplastic Agents, Immunological; Congresses as Topic; Cytarabine; Daunorubicin; fms-Like Tyrosine Kinase 3; Gemtuzumab; Glycine; Humans; Leukemia; Pyridines; Recombinant Fusion Proteins; Staurosporine; Triazines | 2020 |
Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia.
Topics: Biomarkers; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Humans; Leukemia; Leukemia, Myeloid, Acute; Mutation; Nuclear Proteins; Nucleophosmin; Staurosporine | 2021 |
Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A1; Cyclin-Dependent Kinase 2; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Humans; Leukemia; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Staurosporine; Tumor Necrosis Factor-alpha; Ubiquitination | 2009 |
Oral small-molecule tyrosine kinase inhibitor midostaurin (PKC412) inhibits growth and induces megakaryocytic differentiation in human leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; K562 Cells; Leukemia; Megakaryocytes; Protein Kinase Inhibitors; Receptors, Thrombopoietin; Signal Transduction; Staurosporine; Time Factors; Up-Regulation | 2009 |
Smac mimetics: implications for enhancement of targeted therapies in leukemia.
Topics: Animals; Cell Line; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; fms-Like Tyrosine Kinase 3; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Staurosporine | 2010 |
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Topics: Animals; Blotting, Western; Bone Marrow Transplantation; Cell Survival; Cells, Cultured; Disease Progression; Female; Flow Cytometry; Green Fluorescent Proteins; Humans; Leukemia; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutation; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Staurosporine | 2012 |
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Benzoquinones; Caspases; Drug Synergism; HL-60 Cells; Humans; Jurkat Cells; Lactams, Macrocyclic; Leukemia; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Rifabutin; Staurosporine; U937 Cells | 2003 |
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Benzamides; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; K562 Cells; Leukemia; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Sirolimus; Staurosporine | 2004 |
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Caspases; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin D1; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Genes, Dominant; Humans; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Sirolimus; Staurosporine; Time Factors; U937 Cells | 2005 |
[New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
Topics: Acute Disease; Antineoplastic Agents; Carbazoles; Furans; Humans; Indoles; Leukemia; Leukemia, Myeloid, Acute; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinolones; ras Proteins; Staurosporine | 2005 |
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Topics: Animals; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Gene Duplication; Humans; Leukemia; Lymphoma; Mice; Mice, Transgenic; Mutation; Myeloproliferative Disorders; Phenotype; Promoter Regions, Genetic; Protein Kinase C; Staurosporine | 2005 |
[The present status of, and problems with the development of FLT3 kinase inhibitors].
Topics: Adult; Cell Cycle Proteins; Chaperonins; Child; fms-Like Tyrosine Kinase 3; Humans; Leukemia; Leukemia, Promyelocytic, Acute; Mutation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Staurosporine | 2006 |
Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.
Topics: Antineoplastic Agents; Carbazoles; Case-Control Studies; Cell Line; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Inhibitory Concentration 50; Leukemia; Pharmacokinetics; Plasma; Staurosporine | 2006 |
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Topics: Cell Death; Drug Synergism; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Jurkat Cells; Leukemia; Mitogen-Activated Protein Kinase Kinases; Multiple Myeloma; Protein Prenylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Staurosporine; Transfection; Tumor Cells, Cultured; U937 Cells | 2007 |
Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cytarabine; Doxorubicin; Etoposide; fms-Like Tyrosine Kinase 3; Humans; Idarubicin; Leukemia; Methotrexate; Mitoxantrone; Mutation; Protein Kinase C; Staurosporine | 2007 |
Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biomimetic Materials; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; fms-Like Tyrosine Kinase 3; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Mice; Mitochondrial Proteins; Mutant Proteins; Oligopeptides; Staurosporine; Stromal Cells | 2007 |
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipyridamole; Humans; Kinetics; Leukemia; Monocytes; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thioinosine; Thymidine; Tumor Cells, Cultured; Uracil; Uridine | 1994 |
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.
Topics: Alkaloids; Amino Acid Sequence; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Leukemia; Maleimides; Molecular Sequence Data; Protein Kinase C; Protein Serine-Threonine Kinases; Staurosporine; Stem Cells; T-Lymphocytes; Tumor Cells, Cultured | 1995 |
Phorbol ester (TPA)-induced differential modulation of cell surface antigens in human pluripotential leukemia (K-562) cell line: effects of protein kinase inhibitors with broad- and PKC selective inhibitory activity.
Topics: Alkaloids; Antigens, CD; CD59 Antigens; Humans; Intercellular Adhesion Molecule-1; Leukemia; Leukocyte Common Antigens; Lymphocyte Function-Associated Antigen-1; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Modulation of surface TNF expression by human leukaemic cells alters their sensitivity to exogenous TNF.
Topics: Alkaloids; Apoptosis; Cell Cycle; Cell Survival; Cholecalciferol; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Receptors, Tumor Necrosis Factor; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
Topics: Alkaloids; Apoptosis; Camptothecin; Cell Cycle; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Leukemia; Protein Kinase C; Signal Transduction; Staurosporine; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1996 |
Protein kinase C modulates cytosolic free calcium by stimulating calcium pump activity in Jurkat T cells.
Topics: Alkaloids; Calcium; Calcium-Transporting ATPases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Ionomycin; Ionophores; Lanthanum; Leukemia; Naphthalenes; Phorbol Esters; Protein Kinase C; Sodium; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1995 |
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Apoptosis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Mice; Neoplasm Proteins; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis.
Topics: Alkaline Phosphatase; Antibodies, Monoclonal; Cell Cycle; Chromatin; Cyclin A; Cyclin B; Cyclin B1; DNA, Neoplasm; G2 Phase; Histones; HL-60 Cells; Humans; Interphase; Kinetics; Leukemia; Mitosis; Multivariate Analysis; Phosphorylation; Phosphoserine; Staurosporine; Tumor Cells, Cultured; Vinblastine | 1998 |
Role of oxygen radicals generated by NADPH oxidase in apoptosis induced in human leukemia cells.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Camptothecin; Catalase; Cell Differentiation; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Etoposide; Flow Cytometry; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Leukemia; Membrane Glycoproteins; Monocytes; NADPH Oxidase 2; NADPH Oxidases; Neoplasm Proteins; Neutrophils; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Staurosporine; Thiocarbamates; Topoisomerase I Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays | 1998 |
Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines.
Topics: Calcimycin; Carcinogens; Chemokine CCL2; Chemokines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; HL-60 Cells; Humans; Interleukin-8; Ionophores; Leukemia; Protein Biosynthesis; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Cytarabine; Drug Synergism; Enzyme Inhibitors; Humans; Leukemia; Mitochondria; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells | 2000 |
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Arabinonucleotides; Blotting, Western; Drug Interactions; Drug Synergism; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Lymphoma; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Staurosporine; U937 Cells; Vidarabine | 2001 |
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Topics: Alkaloids; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Butadienes; Caspases; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Nitriles; Staurosporine; Tumor Cells, Cultured; U937 Cells | 2001 |
Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.
Topics: Alkaloids; Amino Acid Sequence; Calcium; Cell Line; Cycloheximide; Cytosol; Humans; Inositol; Inositol Phosphates; Kinetics; Leukemia; Molecular Sequence Data; Oligopeptides; Pertussis Toxin; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Virulence Factors, Bordetella | 1992 |
K562 leukemia cells express P2T (adenosine diphosphate) purinergic receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkaloids; Calcium; Fura-2; Leukemia; Protein Kinase C; Receptors, Purinergic; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
Topics: Alkaloids; Amsacrine; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Etoposide; Humans; Leukemia; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1991 |
Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes.
Topics: Alkaloids; Cell Cycle; Chromatin; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Leukemia; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Protein Kinase Inhibitors; Staurosporine; Tumor Cells, Cultured | 1992 |
dsDNA-stimulated phosphorylation of a 72-kDa nucleoprotein accompanies PMA-induced HL-60 leukemic cell differentiation.
Topics: Alkaloids; Cell Differentiation; Deoxyribonucleases; DNA; Humans; Leukemia; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Kinases; Ribonucleases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1.
Topics: Alkaloids; Blotting, Western; Humans; Hydrolysis; Inositol Phosphates; Leukemia; Phosphorylation; Receptors, Antigen, T-Cell; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 1990 |
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by simultaneous activation of distinct signal transduction pathways.
Topics: Adenylyl Cyclases; Alkaloids; Colforsin; Humans; Interleukin-1; Killer Cells, Natural; Leukemia; Protein Kinase C; Receptors, Interleukin-2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.
Topics: Alkaloids; Animals; Antigens; Basophils; Calcimycin; Cell Line; Enzyme Activation; Kinetics; Leukemia; Phosphatidylinositols; Protein Kinase C; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |