staurosporine has been researched along with Leukemia, Myeloid in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.13) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 6 (18.75) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Adamia, S; Buhrlage, S; Case, AE; Gokhale, PC; Gray, N; Griffin, JD; Liu, X; Meng, C; Sattler, M; Stone, R; Tiv, HL; Toure, AA; Wang, J; Weisberg, E; Winer, E | 1 |
| Kihara, T; Matsumoto, T; Nakahashi, Y; Tachibana, K | 1 |
| Bose, P; Cortes, JE; Dalle, IA; Daver, N; DiNardo, C; Garcia-Manero, G; Jabbour, EJ; Kadia, T; Kantarjian, HM; Loghavi, S; Naqvi, K; Patel, K; Pemmaraju, N; Pierce, S; Ravandi, F; Sasaki, K; Short, N; Yalniz, F; Yilmaz, M | 1 |
| Albouhair, S; Lavau, C; Morgado, E | 1 |
| Cotter, TG; Russell, EG; Stanicka, J; Woolley, JF | 1 |
| Burnett, A; Lo-Coco, F; Löwenberg, B; Sanz, M | 1 |
| Baron, E; Basso, G; Beghin, A; Manara, E; Pigazzi, M; Tregnago, C | 1 |
| Agarwal, A; Agarwal, M; Agarwal, MK; Chakrabarti, A; Glick, A; Gupta, K; Sharma, JP; Wald, DN; Yang, J; Zhang, Y | 1 |
| Bornhäuser, M; Brenner, S; Brors, B; Ehninger, G; Heiderich, C; Hofmann, WK; Jacobi, A; Koch, S; Ortlepp, C; Ryser, M; Steudel, C; Thiede, C | 1 |
| Grant, S; Wang, S; Wang, Z | 1 |
| Duyster, J; Grundler, R; Miething, C; Peschel, C; Steudel, C; Thiede, C | 1 |
| Bagrintseva, K; Eichenlaub, S; Ellwart, JW; Hiddemann, W; Kohl, TM; Schnittger, S; Schwab, R; Spiekermann, K | 1 |
| Clark, JJ; Cools, J; Fabbro, D; Furet, P; Gilliland, DG; Griffin, JD; Marynen, P; Mentens, N | 1 |
| Dai, Y; Dent, P; Grant, S; Han, SI; Khanna, P; Mitchell, C; Pei, XY; Rahmani, M | 1 |
| Chang, RL; Conney, AH; Hansson, A; Huberman, E; Klemons, S; Lin, Y; Patel, N; Ryan, A; Shih, WJ; Zheng, X | 1 |
| Berdel, WE; Brandts, C; Choudhary, C; Fischer, T; Kindler, T; Müller-Tidow, C; Sargin, B; Schwäble, J; Serve, H; Tickenbrock, L | 1 |
| Brandts, C; Breitenbuecher, F; Cohen, PS; Ehninger, G; Feldman, E; Fischer, T; Giles, F; Heidel, F; Huber, C; Kasper, S; Kindler, T; Lipka, DB; Nimer, S; Roesel, J; Schiller, GJ; Serve, H; Solem, FK; Stone, RM; Thiede, MH; Wang, Y | 1 |
| Austin, SJ; Burnett, AK; Gilkes, AF; Knapper, S; Mills, KI; Walsh, V | 1 |
| Chung, EJ; Kajiguchi, T; Kiyoi, H; Lee, S; Levis, MJ; Naoe, T; Neckers, L; Stine, A; Trepel, JB | 1 |
| Kfir, S; Sionov, RV; Yefenof, E; Zafrir, E; Zilberman, Y | 1 |
| Hamada, J; Hosokawa, M; Kobayashi, M; Nagayasu, H; Takeichi, N | 1 |
| Bousquet, C; Cassar, G; Colombies, P; Dastugue, N; Demur, C; Jaffrézou, JP; Laredo, J; Laurent, G; Muller, C; Saivin, S | 1 |
| Iversen, PO; Lopez, AF; To, LB | 1 |
| Alamo, I; Carrier, F; Fornace, AJ; Hanaoka, F; Zhan, Q | 1 |
| Bigas, A; Chernukhin, IV; Delgado, MD; Klenova, EM; León, J | 1 |
| Deng, X; Kornblau, SM; May, WS; Ruvolo, PP | 1 |
| Budel, LM; Delwel, R; Elbaz, O; Hoogerbrugge, H; Löwenberg, B; Mahmoud, LA; Touw, IP | 1 |
| Bernstein, SH; Kharbanda, SM; Kufe, DW; Sherman, ML; Stone, RM | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Honma, Y; Hozumi, M; Kasukabe, T; Okabe-Kado, J; Umezawa, K | 1 |
| Barendsen, N; Chen, B; Mueller, M | 1 |
| Isono, K; Magae, J; Osada, H; Watanabe, C | 1 |
2 review(s) available for staurosporine and Leukemia, Myeloid
| Article | Year |
|---|---|
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
Topics: Acute Disease; Animals; Carbazoles; Drug Evaluation, Preclinical; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid; Molecular Structure; Mutation; Staurosporine | 2009 |
Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Interleukin-3; Leukemia, Myeloid; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Prognosis; Protein Kinase C; Protein Kinase C-alpha; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Staurosporine; Structure-Activity Relationship | 2001 |
30 other study(ies) available for staurosporine and Leukemia, Myeloid
| Article | Year |
|---|---|
The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.
Topics: Animals; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid; Mice; Mutation; Proto-Oncogene Proteins c-cbl; Signal Transduction; Staurosporine; Syk Kinase | 2020 |
Mechanical stiffness softening and cell adhesion are coordinately regulated by ERM dephosphorylation in KG-1 cells.
Topics: Actins; Amides; Cell Adhesion; Cell Line, Tumor; Cytochalasin D; Cytoskeletal Proteins; Elasticity; Fibronectins; Humans; Leukemia, Myeloid; Leukocytes; Membrane Proteins; Microfilament Proteins; Microvilli; Phorbol Esters; Phosphorylation; Pyridines; Staurosporine | 2021 |
Sorafenib plus intensive chemotherapy improves survival in patients with newly diagnosed, FLT3-internal tandem duplication mutation-positive acute myeloid leukemia.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Combined Modality Therapy; Female; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Middle Aged; Mutation; Remission Induction; Sorafenib; Staurosporine; Tandem Repeat Sequences; Transplantation, Homologous; Young Adult | 2019 |
Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.
Topics: Animals; Bone Marrow; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Leukemia, Myeloid; Mice; Mice, Knockout; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Signal Transduction; Staurosporine | 2013 |
NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.
Topics: Acute Disease; Animals; Blotting, Western; Cell Line; DNA Damage; fms-Like Tyrosine Kinase 3; Genomic Instability; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia, Myeloid; Mice; Microscopy, Confocal; Mutation; NADPH Oxidase 4; NADPH Oxidases; Protein Kinase Inhibitors; RNA Interference; Signal Transduction; Staurosporine; Tandem Repeat Sequences | 2015 |
ICER evokes Dusp1-p38 pathway enhancing chemotherapy sensitivity in myeloid leukemia.
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Survival; Cyclic AMP Response Element Modulator; Down-Regulation; Doxorubicin; Dual Specificity Phosphatase 1; Dual-Specificity Phosphatases; Enzyme Activation; Etoposide; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mitogen-Activated Protein Kinase Phosphatases; p38 Mitogen-Activated Protein Kinases; Recombinant Proteins; RNA Interference; Staurosporine; Transcription, Genetic; Tumor Cells, Cultured | 2011 |
ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway.
Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Antibiotics, Antineoplastic; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Comet Assay; DNA Damage; Doxorubicin; HEK293 Cells; Humans; Leukemia, Myeloid; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Staurosporine; Thioinosine; Tumor Suppressor Protein p53 | 2012 |
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
Topics: Acute Disease; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Indoles; K562 Cells; Leukemia, Myeloid; Lysophosphatidylcholines; Lysophospholipids; Mutation; Oligonucleotide Array Sequence Analysis; Phosphoric Diester Hydrolases; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Tandem Repeat Sequences | 2013 |
Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms.
Topics: Alkaloids; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bryostatins; Carrier Proteins; Caspases; Cytarabine; Cytochrome c Group; Drug Synergism; Enzyme Activation; Gene Deletion; HL-60 Cells; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Lactones; Leukemia, Myeloid; Macrolides; Maleimides; Mitochondrial Proteins; Mutation; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Staurosporine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.
Topics: Acute Disease; Amino Acid Substitution; Animals; Cell Division; Cell Line; Codon; DNA-Binding Proteins; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Hematopoietic Stem Cells; Humans; Indoles; Leukemia, Myeloid; Membrane Proteins; Mice; Milk Proteins; Mutagenesis, Insertional; Mutation, Missense; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Deletion; STAT5 Transcription Factor; Staurosporine; Structure-Activity Relationship; Trans-Activators; Transfection; Tyrphostins | 2003 |
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cytarabine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genistein; Humans; Indoles; Leukemia, Myeloid; MAP Kinase Signaling System; Milk Proteins; Mutagenesis; Phenotype; Phosphorylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; STAT5 Transcription Factor; Staurosporine; Trans-Activators; Tyrphostins | 2004 |
Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia.
Topics: Acute Disease; Amino Acid Sequence; Animals; Drug Resistance, Neoplasm; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Leukemia, Myeloid; Mice; Models, Molecular; Molecular Sequence Data; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Staurosporine; Structure-Activity Relationship | 2004 |
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Topics: Acute Disease; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Methionine; Mitochondria; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; U937 Cells | 2005 |
Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells.
Topics: Alkaloids; Antineoplastic Agents; Benzophenanthridines; Capsaicin; Carboxylesterase; Carcinogens; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Myeloid; Macrophages; Models, Chemical; Phenanthridines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.
Topics: Acute Disease; Animals; Apoptosis; Cell Line; DNA-Binding Proteins; fms-Like Tyrosine Kinase 3; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Milk Proteins; Muridae; Mutagenesis, Site-Directed; Myeloid Cells; Phosphorylation; Point Mutation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Tandem Repeat Sequences; Trans-Activators; Transcription Factors | 2005 |
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
Topics: Acute Disease; Drug Resistance, Neoplasm; Enzyme Activation; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid; Mutation, Missense; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recurrence; Staurosporine | 2006 |
The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases.
Topics: Acute Disease; Adolescent; Adult; Aged; Apoptosis; Blast Crisis; Carbazoles; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid; Male; Middle Aged; Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 2006 |
FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells.
Topics: Active Transport, Cell Nucleus; Acute Disease; Animals; beta Catenin; Cell Line, Tumor; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Leukemic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Interleukin-3; Leukemia, Myeloid; Membrane Proteins; Mice; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Staurosporine; Transcription, Genetic; Tyrphostins | 2007 |
Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2.
Topics: Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Leukemia, Myeloid; Lymphoma, T-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Phosphotransferases; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Receptors, Steroid; Staurosporine; Transcription Factors | 2007 |
ONO-4007, a new synthetic lipid A derivative, induces differentiation of rat myelomonocytic leukemia cells in vitro and in vivo.
Topics: Alkaloids; Animals; Base Sequence; Benzoquinones; Calmodulin; Cell Division; Cell Transformation, Neoplastic; In Vitro Techniques; Interleukin-1; Interleukin-6; Lactams, Macrocyclic; Leukemia, Myeloid; Lipid A; Molecular Sequence Data; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rifabutin; RNA, Messenger; Staurosporine; Sulfonamides; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Effects of H-7 and staurosporine on proliferation and self-renewal of acute myeloid leukemia progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Alkaloids; Antineoplastic Agents; Cell Cycle; Cell Division; Child; Growth Inhibitors; Hematopoiesis; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Isoquinolines; Leukemia, Myeloid; Neoplastic Stem Cells; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.
Topics: Acute Disease; Alkaloids; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cycloheximide; Cytokines; Dactinomycin; Enzyme Inhibitors; Genistein; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Isoflavones; Kinetics; Leukemia, Myeloid; Phosphorylation; Point Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Reference Values; Staurosporine; Stem Cell Factor | 1996 |
Evidence for distinct kinase-mediated pathways in gadd gene responses.
Topics: Animals; Cell Division; CHO Cells; Cricetinae; DNA Damage; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Immunoblotting; Leukemia, Myeloid; Mice; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Suramin; Transcriptional Activation; Tumor Cells, Cultured | 1998 |
Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells.
Topics: Blotting, Northern; Blotting, Western; Burkitt Lymphoma; CCCTC-Binding Factor; Cell Differentiation; Cytarabine; Dimethyl Sulfoxide; DNA-Binding Proteins; Down-Regulation; Erythrocytes; Gene Expression Regulation; Humans; Isoelectric Focusing; Leukemia, Myeloid; Leukocytes; Megakaryocytes; Phosphorylation; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA Processing, Post-Transcriptional; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 1999 |
Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
Topics: Acute Disease; Alkaloids; Down-Regulation; Granulocyte Colony-Stimulating Factor; Granulocytes; Humans; In Vitro Techniques; Leukemia, Myeloid; Protease Inhibitors; Receptors, Granulocyte Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1991 |
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cell Line; Enzyme Activation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; RNA, Messenger; RNA, Neoplasm; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Inhibition of abl oncogene tyrosine kinase induces erythroid differentiation of human myelogenous leukemia K562 cells.
Topics: Alkaloids; Antibiotics, Antineoplastic; Azepines; Benzoquinones; Cell Differentiation; Cell Division; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Erythrocytes; Genes, abl; Genistein; Humans; Hydroquinones; In Vitro Techniques; Isoflavones; Lactams, Macrocyclic; Leukemia, Myeloid; Myosin-Light-Chain Kinase; Oligonucleotides, Antisense; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Quinones; Rifabutin; RNA, Messenger; Sphingosine; Staurosporine | 1990 |
Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.
Topics: Alkaloids; Cell Differentiation; Cell Division; Gene Expression; Humans; Leukemia, Myeloid; Macrophages; Monocytes; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, Macrophage Colony-Stimulating Factor; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Rapid screening method for inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinomycetales; Alkaloids; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Isoflavones; Isoquinolines; Leukemia, Myeloid; Lyngbya Toxins; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1988 |